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Dena Dubal @denadubal.bsky.social · 3d

What a joy!!

Reposted by Dena Dubal

Veena Dubal @veenadubal.bsky.social · 23d

Today, I had an amazing, unexpected surprise. My big sister came to UC Irvine and sat in on my lecture! It was an amazing, memorable moment. I’ll never forget it. 😭❤️ love you @denadubal.bsky.social

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Reposted by Dena Dubal

American Federation for Aging Research (AFAR) @afar.org · Aug 4

The Wall Street Journal recently highlighted AFAR grantees @denadubal.bsky.social, @jennifergarrison.bsky.social and @jamienjustice.bsky.social in a feature on pioneering women advancing aging research.
Read the full article here: www.wsj.com/health/welln...

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Reposted by Dena Dubal

Bakar Aging Research Institute @ucsfaging.bsky.social · Jun 13

📣 We are thrilled to announce @denadubal.bsky.social is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of #aging, #resilience, and #neurodegenerative_disease. #SciSky #GeroSky

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Dena Dubal @denadubal.bsky.social · May 25

We celebrated with chocolate, stories and tacos! Congrats Samira @jusabdulsam.bsky.social on starting the next chapter of your scientific journey as you set up your own lab at @templeuniversity.bsky.social @ucsfhealth.bsky.social @simonsfoundation.org

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Dena Dubal @denadubal.bsky.social · Apr 23

With gratitude for the Pignolo Prize in Aging Research from UPENN @upenn.bsky.social . Thanks David Wok, Edward Lee, John Pignolo, Virginia Lee - and others. Wonderful occasion!

Daniel Burke Photography of the occasion.

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Dena Dubal @denadubal.bsky.social · Apr 17

"We have far to go and more to do" - thanks Katherine Bourzac @bourzac.bsky.social at @nature.com for including me in this thoughtful piece and highlighting our work on the X chromosome. Why women experience #Alzheimer’s disease differently from men www.nature.com/articles/d41...

Why women experience Alzheimer’s disease differently from men

Sex and gender research could lead to better, more equitable treatments — if it is allowed to continue without political interference.

www.nature.com

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Dena Dubal @denadubal.bsky.social · Apr 12

Congratulations @margaretgadek.bsky.social on a wildly successful PhD! On to the MD!

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Reposted by Dena Dubal

Bakar Aging Research Institute @ucsfaging.bsky.social · Mar 11

Could a reawakening of the silenced X chromosome in females help slow aging-induced cognitive decline? Check out the work by @denadubal.bsky.social along with colleagues Kaitlin Casaletto, Bérénice Benayoun, and Vijay Ramani in Science Advances: bit.ly/3FlN3hj #GeroSky #SciSky

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

www.science.org

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Dena Dubal @denadubal.bsky.social · Mar 7

"A little boost went a long way". Increasing an X factor from the silent X improved cognition in aging male and female mice. Privileged to have our discovery reported in @nytimes.com, alongside findings from Kaitlin Casaletto and Rachel Buckley @bucklr01.bsky.social. www.nytimes.com/2025/03/05/h...

Aging Women’s Brain Mysteries Are Tested in Trio of Studies (Gift Article)

Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s.

www.nytimes.com

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Dena Dubal @denadubal.bsky.social · Mar 6

Thanks Katherine Bourzac @bourzac.bsky.social for this terrific article in @nature.com on our discovery that the "silent X awakens"!

Nature @nature.com · Mar 5

“It’s a paradigm shift to know that the silent X doesn’t stay asleep,” says Dena Dubal, a neuroscientist and neurologist at the University of California School of Medicine in San Francisco, who led the study.

https://go.nature.com/4ksThvP

Why women’s brains are more resilient: it could be their ‘silent’ X chromosome

Study in mice and human cadavers hints that a brain-protective gene in the chromosome becomes more active with age.

go.nature.com

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Dena Dubal @denadubal.bsky.social · Mar 6

With gratitude to collaborators including Vijay Ramani, Kaitlin Casaletto, Rowan Saloner, and Berenice Benayoun @bbparis1984.bsky.social and funders including @simonsfoundation.org and the NIA

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Dena Dubal @denadubal.bsky.social · Mar 6

"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @margaretgadek.bsky.social in Science Advances. www.science.org/doi/10.1126/...

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

www.science.org

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Reposted by Dena Dubal

Katherine Bourzac @bourzac.bsky.social · Mar 5

Thanks to @denadubal.bsky.social and @bucklr01.bsky.social for talking to me for this story about the fascinating X chromosome!

Nature @nature.com · Mar 5

“It’s a paradigm shift to know that the silent X doesn’t stay asleep,” says Dena Dubal, a neuroscientist and neurologist at the University of California School of Medicine in San Francisco, who led the study.

https://go.nature.com/4ksThvP

Why women’s brains are more resilient: it could be their ‘silent’ X chromosome

Study in mice and human cadavers hints that a brain-protective gene in the chromosome becomes more active with age.

go.nature.com

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Dena Dubal @denadubal.bsky.social · Mar 6

Thank you for talking to us and masterfully covering and communicating this discovery with implications for women’s health!

Dena Dubal @denadubal.bsky.social · Mar 6

Major congrats Margaret - wow you worked hard, dug in, and discovered big!!!

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Reposted by Dena Dubal

Margaret Gadek @margaretgadek.bsky.social · Mar 5

Our new Science Advances paper reveals activation of the silent X chromosome as a mechanism of female resilience in cognitive aging www.science.org/doi/10.1126/...

Many thanks to
@denadubal.bsky.social
for your mentorship on this project!!

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

www.science.org

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Reposted by Dena Dubal

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Mar 5

Excited to share our new review article in @cp-trendsgenetics.bsky.social together with the labs of @denadubal.bsky.social, @ctmurphy1.bsky.social and #YousinSuh, spearheaded by trainees Victor Ansere, Seung-Soo Kim, Francesca Marino and Katherine Morillo! 🧪🧬🖥️
www.sciencedirect.com/science/arti...

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Reposted by Dena Dubal

Emily G. Jacobs @emilyjacobs.bsky.social · Mar 6

More coverage of @denadubal.bsky.social Kaitlin Casaletto, @bucklr01.bsky.social et al: www.nytimes.com/2025/03/05/h...

Aging Women’s Brain Mysteries Are Tested in Trio of Studies

Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s.

www.nytimes.com

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Dena Dubal @denadubal.bsky.social · Feb 26

Wonderful talking with Mohana Ravindranath @ravindranize.bsky.social for her compelling article – Why do Women Live Longer than Men? Input from @bbparis1984.bsky.social and others @nytimes.com
www.nytimes.com/2025/02/25/w...

www.nytimes.com

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Reposted by Dena Dubal

Simons Foundation @simonsfoundation.org · Feb 6

Why do women’s brains age better than men’s? A new Simons Foundation–funded @nature.com study from @denadubal.bsky.social identifies a key player: the X chromosome. Read more: www.simonsfoundation.org/2025/02/05/n... #science #neuroscience

New Research Identifies a Key Player in How Your Brain Ages: The X Chromosome

New Research Identifies a Key Player in How Your Brain Ages: The X Chromosome on Simons Foundation

www.simonsfoundation.org

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Reposted by Dena Dubal

American Federation for Aging Research (AFAR) @afar.org · Jan 29

New research by AFAR Grantee @denadubal.bsky.social of @ucsfhealth.bsky.social recently published in @nature.com on the maternal X chromosome and cognition and brain aging in female mice.

Dena Dubal @denadubal.bsky.social · Jan 22

The maternal X chromosome impairs cognition and speeds up brain aging. Check out our latest @nature.com @ucsfhealth.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...

The maternal X chromosome affects cognition and brain ageing in female mice - Nature

The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.

www.nature.com

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Reposted by Dena Dubal

Bakar Aging Research Institute @ucsfaging.bsky.social · Feb 3

👏 Don't miss Samira Abdulai-Saiku's manuscript published in @nature.com! Great work coming from @denadubal.bsky.social's lab, furthering our understanding of the relationship between the X chromosome and brain aging. www.nature.com/articles/s41...

The maternal X chromosome affects cognition and brain ageing in female mice - Nature

The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.

www.nature.com

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Reposted by Dena Dubal

Waggoner Lab @labwaggoner.bsky.social · Jan 22

Older female mice show poor spatial memory when their paternal X chromosome is inactive and only the maternal copy is active @nature.com @denadubal.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...

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Reposted by Dena Dubal

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · Jan 24

Beautiful study from @denadubal.bsky.social and #SamiraAbdulaiSaiku showing that the parent-of-origin of the active X in mice play a huge role in #brain aging!!!!
Congrats on this transformative work!

Dena Dubal @denadubal.bsky.social · Jan 22

The maternal X chromosome impairs cognition and speeds up brain aging. Check out our latest @nature.com @ucsfhealth.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...

The maternal X chromosome affects cognition and brain ageing in female mice - Nature

The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.

www.nature.com

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