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Reposted by Department of Immunobiology at UNIL

Broz Lab @brozlab.bsky.social · 6d

The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.

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Department of Immunobiology at UNIL @dib-unil.bsky.social · 7d

Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne!

@brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Jul 28

New manuscript by Marcell Harhai and the Jourdain lab!

@marcellharhai.bsky.social
@jourdainlab.bsky.social
@fbm-unil.bsky.social
@unil.bsky.social

Alexis A. Jourdain @jourdainlab.bsky.social · Jul 28

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉

🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres

www.cell.com/cell-reports...

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease

Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

www.cell.com

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Jun 24

The whole DIB would like to congratulate Pascal Schneider for his Lifetime Achievement Award!

More info: www.unil.ch/news/1749042...

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Jun 24

Congratulations to Alexandra Boegli for her very successful PhD defense 🎓

Broz Lab @brozlab.bsky.social · Jun 24

A big congratulations to Dr. Alexandra Boegli for very successfully defending her PhD on listeria activation of the elusive NLRP6! Very well deserved and very well celebrated! 🥳

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Reposted by Department of Immunobiology at UNIL

Fabio Martinon @martinon.bsky.social · Apr 11

Big congratulations to Cyrielle Hou (@dib-unil.bsky.social @fbm-unil.bsky.social) for receiving the Young Investigator Award at the 13th Meeting of the International Society of Systemic Autoinflammatory Diseases (ISSAID) in Paris! 🏆👏

And kudos to the organizers for a fantastic conference!

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Reposted by Department of Immunobiology at UNIL

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Jan 28

Confirmed speakers:
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social

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Reposted by Department of Immunobiology at UNIL

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Jan 24

Excited to share our latest paper out today in @naturecomms.bsky.social !

Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.

#ImmunoSky #InterferoSky

The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse - Nature Communications

TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...

www.nature.com

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Reposted by Department of Immunobiology at UNIL

Nature Reviews Rheumatology @natrevrheum.nature.com · Mar 12

Research Highlight ✨|TASL has a key role in SLE

Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖

@rebsamenlab.bsky.social
@dib-unil.bsky.social

Nature Reviews Rheumatology @natrevrheum.nature.com · Feb 28

TASL has a key role in SLE

Nature Reviews Rheumatology, Published online: 28 February 2025; doi:10.1038/s41584-025-01232-xTwo studies provide insights into the function of TASL in the pathogenesis of systemic lupus erythematosus and highlight the therapeutic potential of targeting…

bit.ly

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Mar 14

New preprint from Abigail Strefeler and the Jourdain lab @jourdainlab.bsky.social !

Alexis A. Jourdain @jourdainlab.bsky.social · Mar 14

🚨 New preprint available! Third and final in the #CRISPR screen series!🚨

👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis

www.biorxiv.org/content/10.1...

By A. Strefeler in collaboration with Dave Pagliarini and team.

@DIB_UNIL @FBM_UNIL

🧵 1/9

www.biorxiv.org

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Mar 3

Congrats @elliottbernard.bsky.social !

Broz Lab @brozlab.bsky.social · Feb 25

Congrats to lab member Elliott for winning the poster prize at the Swiss LS2 conference for his work on the activation mechanism of Ninj1 during cell death!! 🥳 @dib-unil.bsky.social @lifesciswitzerland.bsky.social

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Reposted by Department of Immunobiology at UNIL

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Mar 2

🚨Registrations are open🚨

Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.

Attendance is limited to 150 participants!

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Reposted by Department of Immunobiology at UNIL

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Mar 3

Delighted to see our latest paper selected as “Research Highlight” by @natrevrheumatol.bsky.social !
Original study @naturecomms.bsky.social : rdcu.be/d7lK5
#lupus
#innateimmunity
#autoimmunity
#ImmunoSky

Nature Reviews Rheumatology @natrevrheum.nature.com · Feb 28

TASL has a key role in SLE

Nature Reviews Rheumatology, Published online: 28 February 2025; doi:10.1038/s41584-025-01232-xTwo studies provide insights into the function of TASL in the pathogenesis of systemic lupus erythematosus and highlight the therapeutic potential of targeting…

bit.ly

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Feb 12

Postdoc position in the Jourdain Lab

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Jan 30

New preprint from @marcellharhai.bsky.social and @jourdainlab.bsky.social !

Alexis A. Jourdain @jourdainlab.bsky.social · Jan 30

New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Jan 28

New preprint from Alexandra Boegli and the Broz lab!

Broz Lab @brozlab.bsky.social · Jan 28

Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!

www.biorxiv.org/content/10.1...

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...

www.biorxiv.org

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Jan 28

New paper from Ales Drobek and @rebsamenlab.bsky.social in @naturecomms.bsky.social !

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Jan 24

Excited to share our latest paper out today in @naturecomms.bsky.social !

Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.

#ImmunoSky #InterferoSky

The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse - Nature Communications

TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...

www.nature.com

Department of Immunobiology at UNIL @dib-unil.bsky.social · Jan 8

Postdoc position available in the Jourdain Lab!

Alexis A. Jourdain @jourdainlab.bsky.social · Jan 8

📢We're recruiting📢

Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!

Please share

#uridine #cancermetabolism #immunometabolism

@unil.bsky.social

🔗(PDF): www.jourdainlab.org/wp-content/u...

Reposted by Department of Immunobiology at UNIL

Fabio Martinon @martinon.bsky.social · Dec 19

🎓 The PhD program in Cancer and Immunology in Lausanne is accepting applications! If you're passionate about advancing research in cancer or immunology, we want to hear from you! 🌟 #PhD #CancerResearch #Immunology www.unil.ch/cancer-immun...

General information: Application, Admission and Acceptance procedures - UNIL PhD Cancer Immunology

Page Application of site PhD Programme in Cancer and Immunology hosted by the University of Lausanne

www.unil.ch

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Dec 16

Funded postdoctoral position available in the @jourdainlab.bsky.social Lab!

Alexis A. Jourdain @jourdainlab.bsky.social · Dec 16

📢We're recruiting📢

Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!

Please share

#uridine #cancermetabolism #immunometabolism

@unil.bsky.social

🔗(PDF): www.jourdainlab.org/wp-content/u...

Department of Immunobiology at UNIL @dib-unil.bsky.social · Dec 11

New paper from @lbernaleau.bsky.social and @rebsamenlab.bsky.social in @jexpmed.bsky.social!

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Dec 10

Very happy to share our latest work just published in @jexpmed.bsky.social! #Firstpost

rupress.org/jem/article/...

Our amazing PhD student @lbernaleau.bsky.social shows that CCDC134 controls TLR biogenesis through the ER-chaperone Gp96. #ImmunoSky #innateimmunity #inflammation

Quick summary here:

CCDC134 controls TLR biogenesis through the ER chaperone Gp96 | Journal of Experimental Medicine | Rockefeller University Press

A loss-of-function genetic screen identifies the ER-resident protein CCDC134 as an essential regulator of Toll-like receptor (TLR) responses. CCDC134 binds

rupress.org

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Dec 9

New manuscript by Sina Bohnacker and Julia Esser-von Bieren published in Science Immunology!

www.science.org/doi/10.1126/...

A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis

H. polygyrus glutamate dehydrogenase drives parasite chronicity by epigenetically and metabolically reprogramming host macrophages.

www.science.org

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Dec 5

News & Views by @elliottbernard.bsky.social and @brozlab.bsky.social on the resting structure of NINJ1 in @natureportfolio.bsky.social!

Elliott Bernard @elliottbernard.bsky.social · Dec 5

New research revealed how NINJ1 is kept inactive in living cells. Head over to Nature News & Views to check out our thoughts on these cool findings. Free to read at rdcu.be/d2nqH

Broz Lab @brozlab.bsky.social · Dec 4

First real bluesky post 🥳 Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a News & Views, @elliottbernard.bsky.social and Petr describe new results from Dixit & Deshpande, including a resting structure of NINJ1 with 3 helices! Check it out here: rdcu.be/d2nqH

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Department of Immunobiology at UNIL @dib-unil.bsky.social · Nov 20

An image from postdoc Emeline Recazens on the cover of PNAS!

This picture highlights the recent @jourdainlab.bsky.social lab publication led by M. Foged on the role of mitochondrial RNA granules in innate immunity.

Alexis A. Jourdain @jourdainlab.bsky.social · Nov 19

Stressed mitochondrial RNA granules from our recent work on the cover of PNAS!

A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1.

#mitochondria #dsRNA

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