Excited to present at the CSHL Cell Fate Conversions 2025 meeting! Connect with me there to discuss whether your research is a fit for publishing in @stemcellreports.bsky.social. invt.io/1bxba296yhc #cshldirect

Excited to join the Stem Cell Reports team as an Early Career Editor! Grateful for the opportunity to contribute to the journal alongside fantastic colleagues. I encourage you to submit your work for consideration! @isscr.org @stemcellreports.bsky.social

New preprint from the lab! With @brumbaugh-lab.bsky.social , we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. www.biorxiv.org/content/10.1...

Thrilled to share our new work on #aging in the murine hematopoietic system! There is a lot here- stem cell numbers, self-renewal rates, mutation rates, mutation signatures, clonal fitness, environmental effects...

🥂Congrats to @brumbaugh-lab.bsky.social & co for their new study in @naturecellbiology.bsky.social showing that H3K36 methylation maintains #intestinal epithelial fate commitment and is involved in #regeneration.
rdcu.be/d8awu
www.nature.com/articles/s41...

Review @natrevimmunol.bsky.social @distefanolab.bsky.social
Biomolecular condensates in immune cell fate
www.nature.com/articles/s41...

5/ Recent technological advancements have powered these studies, enabling answers to previously unanswerable questions (Fig. 4). Despite this progress, critical evaluation of the evidence concerning condensate properties is essential to understand their role in immune cell fate.

4/ Conversely, dysregulation of condensates has been linked to deleterious immune cell fates, including impaired function, autoimmunity, aging, and malignant transformation (Fig. 3).

3/ Recent studies have implicated condensates in the transcriptional and post-transcriptional processes that drive proper immune cell fates, from the level of hematopoietic stem cells to innate and adaptive immune cells (Fig. 2).

2/ Condensates are diverse, membraneless assemblies of nucleic acids and proteins (Fig. 1). They are thought to enable temporally precise control of gene expression by concentrating or segregating components of the gene regulatory machinery and their targets.

1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...

Great thread from @levin-ferreyra.bsky.social about her latest work in the lab, out today in @emboreports.bsky.social ! 👇