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goodell-lab.bsky.social
Peggy Goodell
@goodell-lab.bsky.social
200 followers 220 following 3 posts
The Goodell Lab. Hematopoietic stem cells, epigenetics, DNA methylation. Houston Texas. Posts are my own.
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Reposted by Peggy Goodell
randolab.bsky.social
randolab.bsky.social @randolab.bsky.social · Jun 30
Happy to share our review at Cell Stem Cell as part of their Hallmarks series. As always, a pleasure to work with friends and colleagues Anne Brunet (@brunetlab.bsky.social) and Peggy Goodell(@goodell-lab.bsky.social).

Hallmarks of stem cell aging: Cell Stem Cell www.cell.com/cell-stem-ce...
Hallmarks of stem cell aging
Aging disrupts core functions of somatic stem cells throughout the body, leading to impaired tissue maintenance and repair. We identify five key features of aged stem cells, highlighting how their dys...
www.cell.com
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goodell-lab.bsky.social
Peggy Goodell @goodell-lab.bsky.social · Jun 30
It was great to work with the inimitable @brunetlab.bsky.social and Tom Rando on this review of stem cell #aging!
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Reposted by Peggy Goodell
brunetlab.bsky.social
BrunetLab @brunetlab.bsky.social · Jun 25
Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...
Hallmarks of stem cell aging
As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …
www.sciencedirect.com
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goodell-lab.bsky.social
Peggy Goodell @goodell-lab.bsky.social · Apr 30
Thank you so much, Dan! It’s such a huge honor. When I started my lab more than 25 years ago, I never imagined this would be possible. I give enormous credit to being in a fantastic supportive environment and many amazing trainees who did all the hard work.
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Reposted by Peggy Goodell
trowbridgelab.bsky.social
Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16
New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & @georgevassiliou.bsky.social as described by @goodell-lab.bsky.social: www.nature.com/articles/d41...
Age-related blood condition counteracted with a common diabetes drug
Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.
www.nature.com
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Reposted by Peggy Goodell
drelmira.bsky.social
Elmira @drelmira.bsky.social · Apr 16
Excited to share the @goodell-lab.bsky.social News&Views on 3 exciting studies by Vassiliou Lab, Chan Lab, and @trowbridgelab.bsky.social in @nature.com and @natcomms.nature.com, showing that #DNMT3A mutant (major driver of Clonal Hematopoiesis) blood cells depend on mitochondrial respiration.
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goodell-lab.bsky.social
Peggy Goodell @goodell-lab.bsky.social · Mar 6
Thrilled to share our new work on #aging in the murine hematopoietic system! There is a lot here- stem cell numbers, self-renewal rates, mutation rates, mutation signatures, clonal fitness, environmental effects...
chiraagkapadia.bsky.social
Chiraag Kapadia @chiraagkapadia.bsky.social · Mar 6
Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis
www.nature.com/articles/s41...
Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature
Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...
www.nature.com
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