1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...

Transposable element activity captures human #pluripotent cell states. #Stemcells @bcmhouston.bsky.social

-> www.embopress.org/doi/full/10....

The latest paper from the Di Stefano lab showing the power of using transposable elements as reporters of different human pluripotent states! www.embopress.org/doi/full/10....

I love a good reporter! TE reporters for capturing distinct hESC states. Looking forward to reading #TEsky

5/5 Together, our study introduces a powerful tool for investigating stem cell potency and offers key insights into the regulation of early embryonic development.

4/5 We also leveraged this reporter system to study regulators of cellular potency.

3/5 This metastable cell population provides a valuable tool for future investigations into both the transcriptional and post-transcriptional barriers to totipotency, as well as the molecular mechanisms underlying this state.

2/5 Unexpectedly, we found that the simultaneous expression of LTR5_Hs and MER51B marks rare, metastable primed cells. These cells are associated with DNA damage and express preimplantation-stage transcripts.

1/5 We have developed a novel dual-fluorescence reporter system that allows us to track cells during transitions between pluripotent states and stem cell differentiation at single-cell resolution.

Excited to share my first manuscript in the @distefanolab.bsky.social , now out in @emboreports.bsky.social! 🎉 We demonstrate how two transposable elements, MER51B and LTR5_Hs, serve as selective indicators of human pluripotency states embopress.org/doi/full/10..... 🧵 below: