#CCESumSchool25 kicked off with a workshop by D. Mertens on scientific writing & PM with #AI, followed by networking & welcome dinner. The stage is set for an inspiring week! ✨

@vhio.bsky.social @nct-heidelberg.bsky.social @crukcamcentre.bsky.social @nkinl.bsky.social @gustaveroussy.fr @ki.se

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Welcome @timcoorens.bsky.social ‪ ‬🇳🇱, our new Research Group Leader.

Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.

www.ebi.ac.uk/about/news/p...
🖥️🧬

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx.
👉 Early cancer detection
👉 Methylation drivers
👉 Epimutation rates
👉 CpG lineage tracing

www.biorxiv.org/content/10.1...

I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo

Polygenic scores (PGS) offer insights into a person’s inherited risk of disease.

GeneticScores.org is a new platform that enables secure, cloud-based calculation of polygenic scores to make genomic risk prediction more accessible.

www.ebi.ac.uk/about/news/u...

🖥️🧬

Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure

Nearly 25 years after we first reported these lesions in @nejm.org!

aacrjournals.org/mcr/article-...

Urinary cfDNA (ucfDNA) offers a truly non-invasive liquid biopsy source. It includes transrenal cfDNA (from blood via glomeruli) and DNA shed locally from the urinary tract. How do these DNA types differ? We explore this in our Med paper: www.cell.com/med/fulltext...

🧬🔬🧫 We have an opening for a senior scientific officer to lead our single cell genomics #techdev and #cancer molecular profiling work @cec-icr.bsky.social

Details and application here: jobs.icr.ac.uk/vacancies/12...

Interested? Please do drop me a line to discuss.

@icr.ac.uk

The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper:
www.nature.com/articles/s41...

Come learn how to apply approaches in evo-eco to cancer biology 🧬 ✨

We have a position open in the lab @cruknbc.bsky.social for a Senior Translational Scientist. If you like #cfDNA #liquidbiopsy, translational research, and their growing range of clinical applications, this job is for you! cruknbc.org/vacancy-seni...

Delighted to share our latest work exploring levels of selection operating during pre-cancerous evolution usng single-cell DNA sequencing of HSCs led by the outstanding Gladys Poon
www.cell.com/cell-genomic...