Doris Kaltenecker
@dorie00.bsky.social
95 followers 110 following 7 posts
Postdoc @Helmholtz Munich. Working in Cancer, #Metabolism, Transcription, Tissue Clearing & #Light-sheet Imaging 🔬
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dorie00.bsky.social
Excited to share that our study on the role of the liver in #CancerCachexia is out in Cell! 😀 🧬

We found that the liver plays an active role in driving weight loss in cancer through disruption of the circadian regulator REV-ERBα and secretion of catabolic hepatokines

www.cell.com/cell/fulltex...
Reposted by Doris Kaltenecker
philipruthig.bsky.social
How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are?

In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️

plos.io/4mq5tOy
#neuroscience #neuroskyence #whitematter #deeplearning
dorie00.bsky.social
Sure, Would be cool! I’m there pretty frequently.
dorie00.bsky.social
Congratulations Jason 👏🏼😀
dorie00.bsky.social
Big thanks to Søren Fisker Schmidt, Stephan Herzig, Mauricio Berriel Diaz and all co-authors for making this possible 🫶🏻

@www.helmholtz-munich.de @diabresearch-dzd.bsky.social @tum.de
@cellpress.bsky.social
dorie00.bsky.social
Excited to share that our study on the role of the liver in #CancerCachexia is out in Cell! 😀 🧬

We found that the liver plays an active role in driving weight loss in cancer through disruption of the circadian regulator REV-ERBα and secretion of catabolic hepatokines

www.cell.com/cell/fulltex...
Reposted by Doris Kaltenecker
helmholtzmunich.bsky.social
🔬 New study: The #liver plays an active role in cancer #cachexia via silenced clock gene REV-ERBα. Key step toward new therapies.

👉 Read more: t1p.de/eh136

@tum.de @diabresearch-dzd.bsky.social @dorie00.bsky.social ky.social #CancerResearch #Cachexia #Liver
Researchers have identified a previously overlooked driver of cachexia: the liver.
Reposted by Doris Kaltenecker
kepecslab.bsky.social
1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
A neuroimmune circuit mediates cancer cachexia-associated apathy
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...
doi.org
Reposted by Doris Kaltenecker
erturklab.bsky.social
See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...
Reposted by Doris Kaltenecker
philipruthig.bsky.social
As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳

Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn....

🧵
Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex
We find that the right and left auditory cortex in mice are both organised in cortical columns, with asymmetric myelination in the different layers and differences between the sexes. In addition, the...
doi.org
Reposted by Doris Kaltenecker
erturklab.bsky.social
Twitter:
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...
dorie00.bsky.social
How does obesity reshape peripheral nerves and immune cells at the whole-body level? 🌟 Our preprint explores this using an AI-driven pipeline to precisely identify, map, and quantify these changes. Thrilled to share it with you here on BlueSky! 🦋😀
www.biorxiv.org/content/10.1...
Reposted by Doris Kaltenecker
erturklab.bsky.social
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
Reposted by Doris Kaltenecker
erictopol.bsky.social
The SARS-CoV-2 spike protein can persist in the brain—in the skull bone marrow and meninges—to induce neurologic damage
www.cell.com/cell-host-mi... open-access
dorie00.bsky.social
Yes 😀 but there wasn’t much going on Bluesky back then 😅
Reposted by Doris Kaltenecker
erturklab.bsky.social
Hey Bluesky! As Erturklab, we are also moving to alternative social media 😉. Stay in touch to follow our work on AI and tissue clearing driven cell-level imaging of intact mouse bodies and human organs, and how we use these methods to study diseases and develop therapeutics at the cellular level.
Reposted by Doris Kaltenecker
Reposted by Doris Kaltenecker
richardsever.bsky.social
bioRxiv goes big on Bluesky: accounts for all subject categories now available (Please Reskeet) connect.biorxiv.org/news/2023/09...
dorie00.bsky.social
Hello Bluesky 🙋🏼‍♀️