Lightnews — Scholar-powered news

Reposted

Luciano A. Masullo @lumasullo.bsky.social · 3d

Thrilled to announce some big news!

Excited to share that I’ve been awarded a Wellcome Trust Early Career Award to establish my research as a Group Leader in the Glycosciences Program at the Institute of Biology and Experimental Medicine (IBYME) in Buenos Aires, Argentina, beginning in early 2026.

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Reposted

Kevin Terretaz @kwolbachia.bsky.social · 4d

I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager!
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...

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Reposted

Dirk Remus @dirkremus.bsky.social · 9d

Great work from Michelle Wang’s group at Cornell exploring how RNAP II and associated R-loops act as intrinsic roadblocks during mechanical DNA unzipping. These findings have mechanistic implications for transcription–replication conflict.

rdcu.be/eILVd

RNA polymerase II is a polar roadblock to a progressing DNA fork

Nature Communications - Transcription–replication conflicts can threaten genome stability. Here, the authors show that RNA polymerase II (Pol II) is a stronger roadblock to a DNA fork in the...

rdcu.be

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Reposted

Jeremy Berg @jeremymberg.bsky.social · 9d

When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety

Who knows what will happen now

Just in case, remember Euruope-PMC
(europepmc.org )

a cartoon of donald trump with the words be prepared above him

ALT: a cartoon of donald trump with the words be prepared above him

media.tenor.com

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Reposted

Stephan Gruber @gruberlab.bsky.social · Sep 5

Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...

With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:

Wadjet—Keeping a watchful eye on circular DNA.

www.cell.com/structure/fu...

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Reposted

Florian Schueder @florianschueder.bsky.social · Jul 31

🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → [email protected]
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

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Reposted

Julian Stingele @jstingele.bsky.social · Jul 21

Now peer reviewed and in its final form @natcomms.nature.com

www.nature.com/articles/s41...

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Reposted

Alessandro Costa @costalaboratory.bsky.social · Jul 21

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Postdoctoral Fellow - Costa Lab

Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

crick.wd3.myworkdayjobs.com

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Reposted

Ellenberg Lab @ellenberglab.bsky.social · Jul 21

Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!

www.nature.com/articles/s41...

Congratulations to Kai and Oyvind!!

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications

A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...

www.nature.com

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Reposted

Nature Microbiology @natmicrobiol.nature.com · Jul 18

Out now:

Structure of an archaeal ribosome reveals a divergent active site and hibernation factor

@jhdcate.bsky.social @banfieldlab.bsky.social @diptinayak.bsky.social & co

#microsky

www.nature.com/articles/s41...

Structure of an archaeal ribosome reveals a divergent active site and hibernation factor - Nature Microbiology

Sequence and structural analyses reveal a divergent peptidyl transferase centre and a hibernation factor in archaea.

www.nature.com

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Reposted

Aga Gambus @agagambus.bsky.social · Jul 11

Very exciting new technology manuscript from @alicepyne.bsky.social lab!
High-res AFM + AI pipeline quantifies complex DNA topology. t.co/qxD7o7ASl6
Very happy to contribute with @singlemoleculenev.bsky.social plasmids replicating past barriers in Xenopus egg extract.
Congratulation everyone!

https://doi.org/10.1038/s41467-025-60559-x

t.co

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Reposted

Max Planck Institute of Biochemistry @mpibiochem.bsky.social · Jul 7

#pictureofthemonth: Illustration of the read-write mechanism by which ubiquitin tags are placed on histone H2A along genes to influence their expression. More: www.biochem.mpg.de/painting-gen...

July – institute calendar of @mpibiochem.bsky.social and @mpiforbi.bsky.social

Image by Tamara Bäßler

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Reposted

Janet Iwasa @jiwasa.bsky.social · Jul 2

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

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Reposted

Gene Center Munich @LMU Munich @genecenter-lmu.bsky.social · Jul 1

🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner! www.cell.com/cell/fulltex...
@v-hornung.bsky.social @m-berouti.bsky.social

Innate immune system: How modified RNA tricks the immune system

Researchers at LMU have elucidated why certain RNA modifications do not trigger an immune response—a key mechanism for RNA therapeutics.

www.lmu.de

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Reposted

Mark Peifer (He, him) @peiferlabunc.bsky.social · Jun 29

It also has devastating cuts to virtually everything I want my taxes to support: science, a safety net, conservation, etc. Call your Senator today--30 seconds will work. Tell them to vote NO on this bill. Tillis is at: (202) 224-6342 3/n

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Reposted

Stand Up for Science! @standupforscience.bsky.social · Jun 29

The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work.

Thousands of lives at risk for tax cuts for the rich? NO THANKS.

Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX

zurl.co/RCR0y
#CutsCostLives

Will the Senate Save NIH?

Rescuing biomedical research is every bit as important as saving Medicaid.

zurl.co

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Reposted

Karolin Luger @nucleosomepolice.bsky.social · Jun 27

new preprint alert from the lab: bringing some order into the wide and wild diversity of archaeal histones. Who has acidic histones? who has multiple histones? what histone combinations do archaea employ and why? find all of this and more here
www.biorxiv.org/content/10.1...

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Reposted

Alessandro Costa @costalaboratory.bsky.social · Jun 20

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

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Reposted

Akis (Argyris) Papantonis @akispapantonis.bsky.social · Jun 19

This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u

A short thread follows 1/n

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duderstadtlab.bsky.social @duderstadtlab.bsky.social · Jun 19

Congrats Lucas! Amazing news!

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Reposted

Cees Dekker @ceesdekker.bsky.social · Jun 16

Latest #CDlab paper online now:
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...

This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social‬) and single-molecule data (Richard Janissen).

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Reposted

Svetlana Dodonova @dodonova-sveta.bsky.social · May 26

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM

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Reposted

Beat Fierz @beatfierz.bsky.social · May 21

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

www.science.org

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Reposted

Vikram Alva @vikramalva.bsky.social · May 12

Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1...

@mpi-bio-fml.bsky.social

A snapshot of the HLp tetramer (purple) wrapping ~60 bp of DNA (green).

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Reposted

Luciano A. Masullo @lumasullo.bsky.social · May 7

Very excited to present our latest work: SPINNA, an analysis framework and software package for single-protein resolution data! 🖥️🤩

We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨

JungmannLab @jungmannlab.bsky.social · May 7

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

We are excited to present our latest work published in @natcomms.nature.com

www.nature.com/articles/s41...

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution - Nature Communications

Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour ...

www.nature.com

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