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Ed Phelps @eaphelps.bsky.social · 22d

LOVE the audio signal in the supplementary videos. Wonderfully creative interpretive aid for the reader/listener. Excellent data, cool work! Congrats!

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Reposted by Ed Phelps

Christos Karampelias @ckarampelias.bsky.social · 26d

New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky

Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators

This study combines live pancreas tissue slices with adenoviral transduction of the Calcium Modulated Photoactivatable Ratiometric Integrator 2 (CaMPARI2) biosensor for high-throughput analysis of isl...

www.biorxiv.org

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Ed Phelps @eaphelps.bsky.social · 27d

Nuc Yellow

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Ed Phelps @eaphelps.bsky.social · Aug 29

Pleased to share our latest article by first author @molliehuber.bsky.social focusing on beta cell function in living pancreas tissue slices from organ donors with T1D, a co-equal collaboration with Clayton Mathews. Includes live videos of insulitis in human T1D. #nPOD

www.cell.com/cell-reports...

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...

www.cell.com

Reposted by Ed Phelps

Mollie Huber @molliehuber.bsky.social · Aug 28

I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social
www.cell.com/cell-reports...

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...

www.cell.com

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Reposted by Ed Phelps

Eric Topol @erictopol.bsky.social · Aug 4

Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM

The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

www.nejm.org

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Ed Phelps @eaphelps.bsky.social · Jun 22

First ADA 5k in the bag. #ADAChicago

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Jun 21

What an amazing time to be a biomedical scientist.

www.nejm.org/doi/abs/10.1...

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

www.nejm.org

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Diabetologia @diabetologiajnl.bsky.social · Jun 10

Human islet proteome changes in stage 1 type 1 diabetes reveals increased inflammation and decreased endoplasmic reticulum stress.
link.springer.com/article/10.1... 🔓

Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donor...

Aims/hypothesis Progression to type 1 diabetes is associated with genetic factors, the presence of autoantibodies and a decline in beta cell insulin secretion in response to glucose. Very little is kn...

link.springer.com

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Ed Phelps @eaphelps.bsky.social · May 23

I had a nightmare last night that I arrived at in-person NIH study section without having read a single assigned grant. And I was rev. 1 on the first grant up for discussion.

Reposted by Ed Phelps

Oded Rechavi @odedrechavi.bsky.social · May 20

When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday

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Reposted by Ed Phelps

Oded Rechavi @odedrechavi.bsky.social · Apr 11

How academics imagine their lives would look like if they decide to work in tech

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Reposted by Ed Phelps

Kimberly Beatty @beattylab.bsky.social · May 13

I'm the 1st scientist in my family. My parents were amazed I could attend @caltech.edu, an elite private school, for my PhD studies FOR FREE. In fact, I was paid to become a PhD chemist. STEM is a pathway to a good career. I study TB- a disease that impacts millions. Fund NIH.

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Reposted by Ed Phelps

Richard Benninger @bennyscience.bsky.social · Apr 29

Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!

www.biorxiv.org/content/10.1...

Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.

While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...

www.biorxiv.org

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Ed Phelps @eaphelps.bsky.social · Apr 16

very sorry to hear about your loss of Rosa

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Ed Phelps @eaphelps.bsky.social · Apr 11

Great session on biomaterials for beta cell replacement in T1D at #SFB2025. Thanks to all the speakers and co-organizer Jess Weaver.

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Ed Phelps @eaphelps.bsky.social · Mar 26

Tracking Ca2+ responses in pancreas just got better! Our latest preprint by Charles Lazimi and Austin Stis showcases CaMPARI 🍸 as a fixable functional marker in living pancreas slices. @cherie-stabler.bsky.social @linnemannlab.bsky.social
www.biorxiv.org/content/10.1...
#CalciumImaging #Diabetes

CaMPARI2 provides a marker of beta-cell function, allowing high content analysis

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Reposted by Ed Phelps

Arjun Raj @arjunraj.bsky.social · Mar 18

Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!

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Reposted by Ed Phelps

Francis Lynn 🇨🇦 @nictitate.bsky.social · Mar 10

We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...

Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375

The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).

www.nature.com

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Ed Phelps @eaphelps.bsky.social · Mar 9

New aquarium denizens

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Ed Phelps @eaphelps.bsky.social · Feb 26

Listen to my interview on our local NPR station @wuft.org show "Tell Me About It" to learn more about this awesome event to connect the public with the research we do on UF's campus. www.wuft.org/podcast/tell...

UF Biomedical Engineering STEM Outreach Day

Dr. Edward Phelps of the University of Florida J. Crayton Pruitt Family Department of Biomedical Engineering talks about STEM Outreach Day on Saturday, March 8 from 10 a.m. to 1 p.m. in the UF Reitz U...

www.wuft.org

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Ed Phelps @eaphelps.bsky.social · Feb 26

Saturday March 8 is UF Biomedical Engineering STEM Outreach Day! Come and learn about the amazing world of Biomedical Engineering. See how our incredible research impacts human health. Event is free and open to the public with free parking! Free cookies and lemonade too!
bme.ufl.edu/events/uf-bi...

UF Biomedical Engineering STEM Outreach Day

Date/Time
Date(s) - 03/08/2025
10:00 am - 1:00 pm

Location
Reitz Student Union

Join us on Saturday, March 8, 2025, from 10 a.m. to 1 p.m. at the Reitz Student Union on the UF campus for a free, family-friendly event designed to spark curiosity and inspire the next generation of STEM leaders. This outreach event is perfect for students in grades K-12, offering an exciting glimpse into the world of biomedical engineering—a field where science, technology, engineering, and mathematics come together to revolutionize healthcare.

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Oded Rechavi @odedrechavi.bsky.social · Feb 19

Exiting the microscopy room

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Reposted by Ed Phelps

Amelia Linnemann @linnemannlab.bsky.social · Feb 21

Proud to share a new preprint from my lab that is the product of hard work from several talented lab members and collaboration with valued colleagues: www.biorxiv.org/content/10.1...

IFN-α Induces Heterogenous ROS Production in Human β-Cells

Type 1 diabetes (T1D) is a multifactorial disease involving genetic and environmental factors, including viral infection. We investigated the impact of interferon alpha (IFN-α), a cytokine produced du...

www.biorxiv.org

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Reposted by Ed Phelps

Patrick MacDonald🇨🇦 @bcellorg.bsky.social · Feb 21

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.

https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

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