Patrick MacDonald🇨🇦
@bcellorg.bsky.social
Professor. CRC. University of Alberta. University of Michigan. Diabetes. Biobanking. Cells, tissues, data. HumanIslets.com, IsletCore.ca, bcell.org
Take a look behinds the sciences of our recent work!
Behind the Scenes: Featuring authors Theodore dos Santos, Xiao-Qing Dai, Patrick E. MacDonald, James G. Lyon, Aliya F. Spigelman, Nancy Smith, Tina Dafoe, and Austin Bautista and their work with IsletCore
December 3, 2025 at 1:08 PM
Take a look behinds the sciences of our recent work!
Reposted by Patrick MacDonald🇨🇦
Behind the Scenes: Featuring authors Theodore dos Santos, Xiao-Qing Dai, Patrick E. MacDonald, James G. Lyon, Aliya F. Spigelman, Nancy Smith, Tina Dafoe, and Austin Bautista and their work with IsletCore
December 2, 2025 at 2:12 PM
Behind the Scenes: Featuring authors Theodore dos Santos, Xiao-Qing Dai, Patrick E. MacDonald, James G. Lyon, Aliya F. Spigelman, Nancy Smith, Tina Dafoe, and Austin Bautista and their work with IsletCore
Reposted by Patrick MacDonald🇨🇦
What can surviving pancreatic cells tell us about type 1 diabetes?
Patrick E. MacDonald @bcellorg.bsky.social analyze pancreatic islet cells from donors with type 1 diabetes, defining pathways and mechanisms responsible for altered insulin and glucagon: doi.org/10.1172/JCI1...
Patrick E. MacDonald @bcellorg.bsky.social analyze pancreatic islet cells from donors with type 1 diabetes, defining pathways and mechanisms responsible for altered insulin and glucagon: doi.org/10.1172/JCI1...
December 2, 2025 at 2:02 PM
What can surviving pancreatic cells tell us about type 1 diabetes?
Patrick E. MacDonald @bcellorg.bsky.social analyze pancreatic islet cells from donors with type 1 diabetes, defining pathways and mechanisms responsible for altered insulin and glucagon: doi.org/10.1172/JCI1...
Patrick E. MacDonald @bcellorg.bsky.social analyze pancreatic islet cells from donors with type 1 diabetes, defining pathways and mechanisms responsible for altered insulin and glucagon: doi.org/10.1172/JCI1...
Reposted by Patrick MacDonald🇨🇦
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes @jci.org @bcellorg.bsky.social @ualberta.bsky.social #T1D
www.jci.org/articles/vie...
www.jci.org/articles/vie...
www.jci.org/articles/vie...
www.jci.org/articles/vie...
December 2, 2025 at 6:32 PM
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes @jci.org @bcellorg.bsky.social @ualberta.bsky.social #T1D
www.jci.org/articles/vie...
www.jci.org/articles/vie...
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Patrick MacDonald🇨🇦
An integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of #islet cells from #T1D donors highlights the importance of α cell dysfunction @albertadiabetes.bsky.social @jci.org @bcellorg.bsky.social www.jci.org/articles/vie...
December 1, 2025 at 6:05 PM
An integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of #islet cells from #T1D donors highlights the importance of α cell dysfunction @albertadiabetes.bsky.social @jci.org @bcellorg.bsky.social www.jci.org/articles/vie...
Reposted by Patrick MacDonald🇨🇦
CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...
youtu.be/UlHn_1Fz3ck?...
#1 Islets in a Pod with Dr. Patrick MacDonald
YouTube video by CIRTN-R2FIC
youtu.be
November 25, 2025 at 4:01 PM
CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...
youtu.be/UlHn_1Fz3ck?...
Reposted by Patrick MacDonald🇨🇦
It was a pleasure to attend the @cirtn.bsky.social workshop. I could not be more impressed by the incredible trainee presentations. And it was a special pleasure to present the first CIRTN Science Communication Award to three amazing scientists: Lahari Basu, Maria Galipeau and Cassandra Locatelli!
November 25, 2025 at 5:43 PM
It was a pleasure to attend the @cirtn.bsky.social workshop. I could not be more impressed by the incredible trainee presentations. And it was a special pleasure to present the first CIRTN Science Communication Award to three amazing scientists: Lahari Basu, Maria Galipeau and Cassandra Locatelli!
Unfortunately can’t be there in person this year, but wishing everyone attending @cirtn.bsky.social national meeting a good time in Toronto!
November 24, 2025 at 1:38 PM
Unfortunately can’t be there in person this year, but wishing everyone attending @cirtn.bsky.social national meeting a good time in Toronto!
Reposted by Patrick MacDonald🇨🇦
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
November 17, 2025 at 11:26 PM
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
'Icicle kick' goes viral: CPL final tops 1 billion views
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/0b881bb4-068b-47e1-aa08-df6969c9f628
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/0b881bb4-068b-47e1-aa08-df6969c9f628
November 14, 2025 at 5:45 PM
'Icicle kick' goes viral: CPL final tops 1 billion views
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/0b881bb4-068b-47e1-aa08-df6969c9f628
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/0b881bb4-068b-47e1-aa08-df6969c9f628
“The New York Times found that at critical points, as measles was gaining new footholds in Canada, provincial politicians stopped public health officials from speaking out about the value of getting vaccinated”
www.nytimes.com/2025/11/06/w...
www.nytimes.com/2025/11/06/w...
Canada Is About to Lose Its Status as Having Eliminated Measles
www.nytimes.com
November 6, 2025 at 1:18 PM
“The New York Times found that at critical points, as measles was gaining new footholds in Canada, provincial politicians stopped public health officials from speaking out about the value of getting vaccinated”
www.nytimes.com/2025/11/06/w...
www.nytimes.com/2025/11/06/w...
Reposted by Patrick MacDonald🇨🇦
Robert Munsch has donated his personal archives of stories and materials to the Guelph Public Library.
This is wonderful for such a valuable archive to be given to a public municipal library.
www.guelphpl.ca/Modules/News...
This is wonderful for such a valuable archive to be given to a public municipal library.
www.guelphpl.ca/Modules/News...
Robert Munsch donates his archives to Guelph Public Library
Robert Munsch donates his archives to Guelph Public Library
www.guelphpl.ca
November 4, 2025 at 11:31 PM
Robert Munsch has donated his personal archives of stories and materials to the Guelph Public Library.
This is wonderful for such a valuable archive to be given to a public municipal library.
www.guelphpl.ca/Modules/News...
This is wonderful for such a valuable archive to be given to a public municipal library.
www.guelphpl.ca/Modules/News...
Reposted by Patrick MacDonald🇨🇦
Budget analysis part 1
Canadian Federal Budget 2025 Part 1
YouTube video by Higher Education Strategy Associates
www.youtube.com
November 4, 2025 at 10:59 PM
Budget analysis part 1
How much are MPs entitled to know about research grants? Not as much as you think. - Globe and Mail
November 4, 2025 at 11:19 AM
How much are MPs entitled to know about research grants? Not as much as you think. - Globe and Mail
Reposted by Patrick MacDonald🇨🇦
🧵(1/4) We have finished up October 2025 🎃, and the CIRTN groups had several more publications coming from the labs of Drs Rennian Wang, Megan Levings and Marc Prentki.
November 3, 2025 at 7:42 PM
🧵(1/4) We have finished up October 2025 🎃, and the CIRTN groups had several more publications coming from the labs of Drs Rennian Wang, Megan Levings and Marc Prentki.
Reposted by Patrick MacDonald🇨🇦
This! Fancy web interfaces let you explore the data, but they are not the same as sharing the data. You can do both!
PSA: it’s all great if you provide an interactive dashboard to browse the data you painstakingly generated. But please do back up the data on persistent archive like zenodo. It’s too bad we can’t access the database when inevitably the server goes down and you moved onto other projects/institutions
October 31, 2025 at 7:16 PM
This! Fancy web interfaces let you explore the data, but they are not the same as sharing the data. You can do both!
Reposted by Patrick MacDonald🇨🇦
If you are a Canadian scientist interested in the protection of identifying information about applicants and reviewers of tricouncil grants please read and sign this letter. Thank you. docs.google.com/forms/d/e/1F...
Open Letter to Protect Tri-Council EDI Data
Why do we need urgent action to protect our data?
The mandate of the House of Commons Standing Committee on Science and Research is to review and report on topics relating to science and research in ...
docs.google.com
October 31, 2025 at 6:31 PM
If you are a Canadian scientist interested in the protection of identifying information about applicants and reviewers of tricouncil grants please read and sign this letter. Thank you. docs.google.com/forms/d/e/1F...
Reposted by Patrick MacDonald🇨🇦
📢 Support Our Science in the news!
We’re proud to be featured in CTV News’ latest story on Canada’s emerging “brain gain” — a scientific migration as researchers look north amid challenges in the U.S.
We’re proud to be featured in CTV News’ latest story on Canada’s emerging “brain gain” — a scientific migration as researchers look north amid challenges in the U.S.
Over 600 scientists-half from the U.S.-raised their hand for a position at Toronto’s University Health Network- meet one who has moved to 🇨🇦. A scientific migration amid U.S turmoil
www.ctvnews.ca/health/artic... @ctvnews-mirror.bsky.social @uhn.ca @supportourscience.bsky.social
www.ctvnews.ca/health/artic... @ctvnews-mirror.bsky.social @uhn.ca @supportourscience.bsky.social
Canada’s brain gain: A scientific migration amid U.S turmoil
More than 600 scientists – about half from the U.S. – ‘raise their hands’ as they compete for positions at a Canadian Hospital.
www.ctvnews.ca
October 22, 2025 at 12:31 AM
📢 Support Our Science in the news!
We’re proud to be featured in CTV News’ latest story on Canada’s emerging “brain gain” — a scientific migration as researchers look north amid challenges in the U.S.
We’re proud to be featured in CTV News’ latest story on Canada’s emerging “brain gain” — a scientific migration as researchers look north amid challenges in the U.S.
Interesting paper, but does anyone know if the claim that “…The datasets (genome-wide raw sequencing and individual-level clinical data) … are not publicly available due to EU and national legislation” is reasonable?
https://www.nature.com/articles/s41598-025-21595-1
https://www.nature.com/articles/s41598-025-21595-1
October 17, 2025 at 1:27 PM
Interesting paper, but does anyone know if the claim that “…The datasets (genome-wide raw sequencing and individual-level clinical data) … are not publicly available due to EU and national legislation” is reasonable?
https://www.nature.com/articles/s41598-025-21595-1
https://www.nature.com/articles/s41598-025-21595-1
Reposted by Patrick MacDonald🇨🇦
🧵(1/4) For the first half of October 2025 we have 3 publications from the CIRTN labs🍁. These papers are from the groups of Drs. Bruce Verchere, Yi-Chun Chen, Francis Lynn, James Shapiro, Tatsuya Kin and Guy Rutter!
October 16, 2025 at 1:57 AM
🧵(1/4) For the first half of October 2025 we have 3 publications from the CIRTN labs🍁. These papers are from the groups of Drs. Bruce Verchere, Yi-Chun Chen, Francis Lynn, James Shapiro, Tatsuya Kin and Guy Rutter!
Reposted by Patrick MacDonald🇨🇦
Today, #ForeverCanadian brought 230,000 petition signatures to Edmonton. Our volunteers will continue collecting signatures until October 28. We need your signature to reach our 300,000 requirement to keep Alberta in Canada.
#ableg #Yeg #Yyc #CdnPoli
#ableg #Yeg #Yyc #CdnPoli
October 3, 2025 at 8:36 PM
Today, #ForeverCanadian brought 230,000 petition signatures to Edmonton. Our volunteers will continue collecting signatures until October 28. We need your signature to reach our 300,000 requirement to keep Alberta in Canada.
#ableg #Yeg #Yyc #CdnPoli
#ableg #Yeg #Yyc #CdnPoli
Reposted by Patrick MacDonald🇨🇦
🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!
October 1, 2025 at 8:50 PM
🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!
Reposted by Patrick MacDonald🇨🇦
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
September 30, 2025 at 4:45 PM
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
Yesterday we celebrated our 600th human research islet isolation in support of diabetes research (and then last night isolated the islets in the pic). I’m very fortunate to work with such a dedicated team! See more at www.isletcore.ca
September 30, 2025 at 1:09 PM
Yesterday we celebrated our 600th human research islet isolation in support of diabetes research (and then last night isolated the islets in the pic). I’m very fortunate to work with such a dedicated team! See more at www.isletcore.ca