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Thomas Elbenhardt Jensen @elbenhardt.bsky.social · Jul 1

In our latest paper, we show that inducible sk. muscle AXIN1 /2 double KO have normal AMPK, mTOR and glucose uptake regulation, questioning previously proposed dependencies on this scaffold protein. Thanks to all co-authors for their contributions
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Muscle‐specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism

Abstract figure legend This study investigated the role of AXIN1 and AXIN2 in regulating skeletal muscle AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) sig....

physoc.onlinelibrary.wiley.com

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Reposted by Thomas Elbenhardt Jensen

Juleen R. Zierath @juleenrzierath.bsky.social · Apr 30

Latest from Jonas Treebak and team @cbmr.science

NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

www.sciencedirect.com

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Reposted by Thomas Elbenhardt Jensen

Carlos Henriquez-Olguin @musclebiology.bsky.social · Mar 27

Check out our latest paper challenging the long-standing belief that insulin elicits a transient H₂O₂ production. New insights into skeletal muscle redox signaling and insulin action 🤩

Thomas Elbenhardt Jensen @elbenhardt.bsky.social · Mar 26

Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy
www.sciencedirect.com/science/arti...

Revisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal Muscle

The intracellular redox state is crucial for insulin responses in peripheral tissues. Despite the longstanding belief that insulin signaling increases…

www.sciencedirect.com

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Thomas Elbenhardt Jensen @elbenhardt.bsky.social · Mar 26

Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy
www.sciencedirect.com/science/arti...

Revisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal Muscle

The intracellular redox state is crucial for insulin responses in peripheral tissues. Despite the longstanding belief that insulin signaling increases…

www.sciencedirect.com

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Reposted by Thomas Elbenhardt Jensen

Christoph Handschin @c-handschin.bsky.social · Jan 30

“Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison” by @robertoandresmv.bsky.social, @musclebiology.bsky.social, @elbenhardt.bsky.social et al. (sorry if I do not find all of the #bluesky handles).

www.sciencedirect.com/science/arti...

3/17

Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison

Striated muscle cells, encompassing cardiac myocytes and skeletal muscle fibers, are fundamental to athletic performance, facilitating blood circulati…

www.sciencedirect.com

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Reposted by Thomas Elbenhardt Jensen

Deutsches Zentrum für Diabetesforschung (DZD) @diabresearch-dzd.bsky.social · Jan 21

🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social‬ at our DZD-Partne#DIfEfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️

Maximilian Kleinert @mkleinert.bsky.social · Jan 6

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications

Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

www.nature.com

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Thomas Elbenhardt Jensen @elbenhardt.bsky.social · Jan 21

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

mTOR Ser1261 is an AMPK‐dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity

mTOR Ser1261 is an AMPK-dependent phosphosite in human and mouse skeletal muscle that responds to exercise but not insulin, plays an unclear role in mTORC1 regulation, and is not required for mTORC2 ....

faseb.onlinelibrary.wiley.com

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Reposted by Thomas Elbenhardt Jensen

Maximilian Kleinert @mkleinert.bsky.social · Jan 6

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications

Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

www.nature.com

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Reposted by Thomas Elbenhardt Jensen

Craig A. Goodman @craigagoodman1.bsky.social · Jan 3

Pantothenate kinase 4 controls skeletal muscle substrate metabolism
www.nature.com/articles/s41...

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications

Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

www.nature.com

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Reposted by Thomas Elbenhardt Jensen

Plant Energy Biology Lab @schwarzlanderlab.bsky.social · Dec 19

A new biosensor is born 👼
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫

Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱

Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...

A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes - Nature Communications

This article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell...

doi.org

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Reposted by Thomas Elbenhardt Jensen

Altmetric @altmetric.com · Dec 10

🌟 ICYMI: Altmetric now tracks Bluesky mentions!

✔️ Comprehensive social media coverage
📊 Mentions reflected in your Altmetric score
🌐 Stay ahead in tracking research discussions

Your research is moving to new spaces—don’t miss a thing! Read more here: www.altmetric.com/bl...

#AcademicSky

Tapping into data from Bluesky

Altmetric has expanded its tracking capabilities by integrating data from Bluesky, the rapidly growing social media platform with over 24 million users.

www.altmetric.com

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Reposted by Thomas Elbenhardt Jensen

Juleen R. Zierath @juleenrzierath.bsky.social · Nov 27

New from Anna Krook and team. Biological sex differences in skeletal muscle metabolism and exercise adaptation in People with type 2 diabetes
#myoblue #exercise #metabolism
www.nature.com/articles/s41...

Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus - Nature Reviews Endocrinology

This Review focuses on currently available literature describing sex differences in skeletal muscle metabolism in humans, as well as highlighting current research gaps within the field. These discussi...

www.nature.com

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Reposted by Thomas Elbenhardt Jensen

Joseph Gordon @josephwgordon.bsky.social · Nov 22

www.cell.com/cell-metabol...

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Reposted by Thomas Elbenhardt Jensen

Thibaux Van der Stede @thibauxvanderstede.bsky.social · Nov 18

Let’s try out this new platform by sharing our recent paper on the transcriptional signatures of individual muscle fibers following high-intensity exercise
#myoblue #myosky

journals.physiology.org/doi/abs/10.1...

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Reposted by Thomas Elbenhardt Jensen

Vanessa is the name of the Doctor! @hpsvanessa.bsky.social · Nov 20

Neither the conference organisers nor the artist are (yet) on here but look at this amazing live drawn summary of my #MetabolismInAction paper by Eleonora Nigro #HistSTM #PolarHistory

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