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Elisa Fadda

@elisafadda.bsky.social

2.4K followers 1.5K following 1.3K posts

Associate Professor in the School of Biological Sciences at the University of Southampton, head chef at https://GlycoShape.org, Salem's butler, fucose fanatic #glycotime everyday! She/Her

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Elisa Fadda @elisafadda.bsky.social · Nov 13

As we (my lab and I) are new here 😻, let me introduce some exciting #glycotime work we recently published in Nature Methods doi.org/10.1038/s415... GlycoShape is a completely OA database and toolbox to restore the 3D structure of glycans on glycoproteins 🥳 You can find it at glycoshape.org 1/2

artistic rendition of glycoproteins 3D structures anchored on the cell surface and soluble with the glycans restored with https://glycoshape.org

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Reposted by Elisa Fadda

C&EN (Chemical & Engineering News) @cenmag.bsky.social · 5h

The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...

#ChemNobel #Chem #Chemistry #chemsky 🧪

The 2025 chemistry Nobel goes to MOFs

Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks

cen.acs.org

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Reposted by Elisa Fadda

Stu Cantrill @stuartcantrill.com · 5h

Time to break out this pic of me being strangled by a future #Nobel Laureate in 2017… #Chemsky #chemnobel…

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Elisa Fadda @elisafadda.bsky.social · 5h

it's MOF fTw!! 🎉🧪 #chemsky

In fairness, it was unlikely to have computational Nobel for two years in a row.... but next year is game ON! 🧑🏻‍💻😁
www.nobelprize.org

The official website of the Nobel Prize - NobelPrize.org

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

www.nobelprize.org

Reposted by Elisa Fadda

Stu Cantrill @stuartcantrill.com · 5h

It's MOFs #ChemNobel #Chemsky

Stu Cantrill @stuartcantrill.com · 2d

#NobelPrize week starts tomorrow & the #chemnobel is Wednesday… used to be so much Nobel chat on Tw*tter, but that is not replicated here, alas. Anyway, for the record, I think MOFs will win at some point (maybe this year maybe not). Balasubramanian & Klenerman a good bet for next-gen sequencing too

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Elisa Fadda @elisafadda.bsky.social · 8h

That's such a lovely memory. May all your #ChemNobel predictions ring true to soften the day 😊 but I am sure Prof Stoddard really admired Car and Parrinello 😁

Reposted by Elisa Fadda

Stu Cantrill @stuartcantrill.com · 8h

It’s #chemnobel day. For me, and for quite a few other people who spent time in the Stoddart group, it will hit somewhat differently this year.

Seems the right time to share a couple of passages from the eulogy I gave at Fraser’s funeral earlier this year.

A screenshot of text that reads:

Fraser lived his life at a hundred miles an hour. But it wasn't always the best thing for him or for those closest to him. In an interview following the award of the Nobel Prize in 2016 he recalled his time growing up on a farm and said that that had instilled in him the work ethic of a honeybee. Nobody would doubt that he had that. He also talked about having the strength of a horse and the hide of an elephant; what he didn't mention is that he could also be as stubborn as a mule. He did things his way and was rarely persuaded to do otherwise.

This bloody-mindedness undoubtedly contributed to his incredibly successful career. While those who didn't really know him will measure his contributions through the prizes he won, his real professional legacy is not those prizes, it is the people who passed through his lab and shared in his scientific journey. Yes, he changed science, but he changed lives too - including mine and many of those here today. I learned a lot from Fraser: some chemistry, how to make slides for presentations, how to always include a noun after the word 'this', and a few random Scottish words that I'm still not convinced he didn't just make up.

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Reposted by Elisa Fadda

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 18h

The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert)

Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation

doi.org/10.1101/2025...

Fig. 1 – UBQLN2 is a conserved lysine-depleted protein. (A) Sequence comparison of
UBQLN2 orthologs in the indicated species. Intrinsically disordered regions in human
UBQLN2 based on MobiDB are shown as a blue bar. The domain organization based on the
SMART database is marked. Lysine residues are marked as black squares. (B) ESM-2
predictions of all possible single amino acid substitutions of human UBQLN2 presented as a
heat map. The wild-type residues are marked in blue. ESM-2 scores close to zero (light
yellow colors) indicate that the amino acid substitution is compatible with the ESM-2
language model, whereas negative scores (dark orange colors) indicate that the variant is
incompatible with the ESM-2 model. The domain organization (based on SMART) is aligned
above the map. Note that substitutions to lysine or cysteine in general appear detrimental, in
particular downstream of the UBL domain. (C) The AlphaFold2 predicted structured of
human UBQLN2 (AF-Q9UHD9-F1) (left panel). The UBL domain is colored blue, and the
UBA domain is colored orange and the STI1 regions green. Zoom in on the UBL domain
(right panel) with the lysine residues highlighted as stick representations and colored based
on the relative accessible surface area (rASA, dark red exposed; grey, buried).

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Reposted by Elisa Fadda

Jeremy Berg @jeremymberg.bsky.social · 1d

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

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jeremymberg.github.io

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Elisa Fadda @elisafadda.bsky.social · 20h

2/2 my personal favourite,

2) Anna Krylov and Jay Tanzman blog post about the pivotal contribution of cats to (quantum) chemistry:

hxstem.substack.com/p/chemistry-...

Happy reading! 😺🎉 🧪

Chemistry with Cats

From Schrödinger's Paradox to Quantum Computing

hxstem.substack.com

Elisa Fadda @elisafadda.bsky.social · 20h

Tomorrow is #ChemNobel day!! 🥳🥳 While we are all waiting eagerly for the announcement, my cat Salem suggest to you #chemsky friends some important reading to quench the nerves,

1) ACS important content: www.acs.org/pressroom/re...

And... 1/2 🧵

The Chemistry of Cats | Reactions Science Videos - American Chemical Society

A look at some of the key "meow-locules" that make up the chemistry of cats.

www.acs.org

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Reposted by Elisa Fadda

April Wright @wrightam.bsky.social · 1d

Continuing my tour of books I should have already read, Calling Bullshit by @carlbergstrom.com and @jevinwest.bsky.social. Just a delight - an accessible, entertaining, insightful look at various forms of BS. Much like Weapons of Math Destruction, would love a 2025 update of this one.

Calling Bullshit: Data Reasoning in a Digital World

The world is awash in bullshit. Politicians are unconstrained by facts. Science is conducted by press release. Higher education rewards bullshit over analytic thought. Startup culture elevates bullshi...

www.callingbullshit.org

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Reposted by Elisa Fadda

Stu Cantrill @stuartcantrill.com · 23h

The @natureportfolio.nature.com Collection celebrating the 2025 #NobelPrize in #Physics is now live!

Nobel Prize in Physics 2025

The Nobel Prize in Physics 2025 was awarded to John Clarke, Michel H. Devoret and John M. Martinis "for the discovery of macroscopic quantum mechanical ...

www.nature.com

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Elisa Fadda @elisafadda.bsky.social · 23h

Congrats to all!! Brilliant 👍🏻🥳🥳👏🏻👏🏻

Elisa Fadda @elisafadda.bsky.social · 23h

Wow! This is magnificent #glycotime Anne! I thought only I could see hydrogen atoms!! 😂😂🥳🥳

Reposted by Elisa Fadda

Anne Imberty @anneimb.bsky.social · 1d

Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration

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Reposted by Elisa Fadda

Dr. Jens Foell @jensfoell.de · 1d

This sounds plausible to me. But if it’s true, it means that the age of social media might be over soon, with only the old and wrinkled (like myself) spending any actual time there.

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Elisa Fadda @elisafadda.bsky.social · 1d

This is fabulous #glycotime!! 😍 Super congrats to you all! 👏🏻👏🏻👏🏻

Reposted by Elisa Fadda

Ben Schumann @drglycoben.bsky.social · 1d

Check our new venture into drug discovery #glycotime!

Ben Schumann @drglycoben.bsky.social · 1d

Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social

chemrxiv.org/engage/chemr...

Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase

O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...

chemrxiv.org

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Reposted by Elisa Fadda

Adrian Woolfson @adrianwoolfson.bsky.social · 1d

www.pnas.org/doi/10.1073/...

Generative AI for computational chemistry: A roadmap to predicting emergent phenomena | PNAS

The recent surge in generative AI has introduced exciting possibilities for computational chemistry. Generative AI methods have made significant pr...

www.pnas.org

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Reposted by Elisa Fadda

Zack Labe @zacklabe.com · 1d

October has observed some of the largest warming trends in the #Arctic. This is greatest over areas with a lack of sea ice cover (nearly all of the Siberian Arctic). Arctic amplification is largest in the boreal fall.

Data: doi.org/10.24381/cds.... Info: doi.org/10.1175/BAMS....

Polar stereographic map of 2-m temperature trends in units of °C per decade over the Arctic for the month of October. Trends are calculated over the 1979 to 2024 period using ERA5. The largest warming is an areas of open water that were previously sea ice covered along the Siberian side of the Arctic. These trends exceed 2°C/decade in these areas.

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Reposted by Elisa Fadda

Alexander Verbeek @alexverbeek.bsky.social · 1d

Jane Goodall's last interview released: "Don't lose hope." Today's stories prove she was right.
Take a moment to listen to her words:
 daybreaknotesandbeans.substack.com/p/dont-lose-...

Don’t Lose Hope: Jane Goodall’s Last Interview and Today’s Stories of Progress That Prove Her Right

Plus: A Nobel Prize for genetic scissors, young climate activists triumph at the ICJ, a dinosaur caught mid-meal, and why women outlive men

daybreaknotesandbeans.substack.com

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Elisa Fadda @elisafadda.bsky.social · 1d

This ⤵️ is on my XMas/bday 🎁 wish list! 🎄😍😍 @princetonupress.bsky.social

press.princeton.edu/books/hardco...

Insect Architecture

The essential illustrated guide to the ingenious techniques that insects use to construct an astounding array of natural structures, from nests to shelters to traps

press.princeton.edu

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Reposted by Elisa Fadda

The Well-read Naturalist @wellreadnaturalist.bsky.social · 1d

🏢📐✏️🐜

😉 #Booksky

Princeton University Press @princetonupress.bsky.social · 1d

Blending spectacular illustrations with illuminating case studies of representative species from around the world, Insect Architecture by Michael S. Engel and Tom Jackson is the ultimate guide to insect artistry and innovation.

Out now. Explore a free sample: press.princeton.edu/books/hardco...

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Reposted by Elisa Fadda

Richard Sever @richardsever.bsky.social · 1d

New blog post. In which I analyze the new HHMI announcement and what it means for the science publishing ecosystem openrxiv.org/preprint-man...

Preprint mandates gather momentum - openRxiv

By Richard Sever, PhD. Chief Science & Strategy Officer, openRxiv Preprints speed up science by enabling researchers to disseminate reports of new findings immediately. They also represent a simple wa...

openrxiv.org

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Reposted by Elisa Fadda

Avogadro Project @avogadro.cc · 2d

If you've been wondering about the status of the AutoOptimize interactive optimization in Avogadro2 - coming later this month 👀

Screenshot of Avogadro2 using the interactive AutoOptimize tool to minimize a molecule (n-pentane) using the UFF force field. Text reads UFF ΔE = -229.80 kcal/mol

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