Erwin Schoof
@erwinschoof.bsky.social
740 followers 170 following 31 posts
Biological Mass Spectrometry enthusiast, trying to make sense of cellular hierarchies and heterogeneity
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erwinschoof.bsky.social
Super exciting Matthias, congratulations! 😃
Reposted by Erwin Schoof
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Reposted by Erwin Schoof
ionopticks.bsky.social
@kentsisresearch.bsky.social develop a proteogenomics workflow to detect 1000s of unknown cancer proteins. PG3 combines long-read RNA sequencing with multi-protease MS to discover non-canonical proteins in cancer cells. Used a timsTOF HT, nanoElute 2 & Aurora Ultimate 25x75 column:
bit.ly/4mlQSmu
Reposted by Erwin Schoof
wkhuber.bsky.social
When testing a computational data analysis method: simulated data are good for checking whether the method is doing what you think it should be doing, real data for checking whether what you think it should be doing is any good.
Reposted by Erwin Schoof
pastelbio.bsky.social
Are Solid Particles Ready for Prime-Time Proteomics? pubs.acs.org/doi/10....

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#proteomics #prot-paper
Reposted by Erwin Schoof
ajbrenes.com
Start of the European symposium in single cell proteomics at beautiful Viena with a workshop on spatial proteomics organised by @coscialab.bsky.social
Reposted by Erwin Schoof
pastelbio.bsky.social
Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics www.science.org/doi/...

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#proteomics #prot-paper
erwinschoof.bsky.social
Only a few more hours! 😃
kmechtler.bsky.social
The European Symposium on Single Cell Proteomics (ESCP) will be held in Vienna for the 6th time, from August 26th – 27th 2025 This year's focus will include spatial proteomics studies on the single-cell level. There is no registration fee
Hotel rooms in Vienna are inexpensive.
www.apma.at/6thescp/
6th ESCP 2025 – APMA
www.apma.at
Reposted by Erwin Schoof
jkmcbee.bsky.social
Here’s an interesting story for #teammassspec. Liraglutide went generic in December 2024 and we have been developing methods for impurity characterization but we kept seeing an unusual modification with a +12 Da shift. A little digging revealed that others had noticed that the n-terminal histidine..
erwinschoof.bsky.social
That was a later upgrade as projects got bigger and bigger - long live the RAID cards 😅
erwinschoof.bsky.social
We built a custom Thread ripper (7980X) rig with 256Gb of RAM and 24Tb of SSD to plough through all the single-cell raw files. Up-front investment, but cheaper in the long run compared to paying for CPU time on an HPC. And it's FAST, runs my whole lab! 😅
erwinschoof.bsky.social
Very cool stuff indeed Luke, congrats!
Reposted by Erwin Schoof
lgamon.bsky.social
Pumped to finally show off our spatial proteomics work presented a few weeks ago at the EAS Congress @eassociety.bsky.social and now live on @biorxivpreprint.bsky.social 🥳

Time for a science thread! #TeamMassSpec #SpatialProteomics #AtheroSky 🧵

www.biorxiv.org/content/10.1...
www.biorxiv.org
Reposted by Erwin Schoof
melbrunner.bsky.social
Tried presenting my data at #EuPA2025. Then decided to scale things up... Turns out, volcano plots look great in sand and people are more interested in what we scientists do.
#Proteomics #YPIC #YPIContest2025
Reposted by Erwin Schoof
o.simardcasanova.net
The reports of Bluesky’s death have been greatly exaggerated
altmetric.com
The trend is still in Bluesky's favour. X is still larger but very regularly Bluesky easily eclipses it in terms of research being shared.

Linda Yaccarino claimed X had 600m users in April. Bluesky has 36m accounts created in total.
Graph showing Twitter vs Bluesky research postings. 3rd June 2025 shows 26,725 posts on Bluesky, X has 20,779 by comparison.
Reposted by Erwin Schoof
mtrost.bsky.social
The financial crisis of the HE sector in the UK now leads to increased numbers of grant and fellowship applications, pushing down the success rates. Since also overheads increased, in some cases we will see success rates halved.

There is a BBSRC fellowship which will have a success rate of 5%.
erwinschoof.bsky.social
It is so crazy! Not that I have answers, but more money is clearly needed to bring funding rates back to 15-20% to ensure all the great ideas get to be pursued. And this problem is unfortunately not limited to the UK; a Danish call earlier this year only funded 4 out of 77 applications-> that's 5%!
erwinschoof.bsky.social
#ThermoFisher #IonOpticks #EvoSep #Cellenion #Biognosys
erwinschoof.bsky.social
And last but not least, a big shout out to our valuable tech partners, without whom we couldn't do what we really want: namely making a difference in the world with biological discoveries through single-cell proteomics by Mass Spectrometry
erwinschoof.bsky.social
Another big shout out to the organizers of #EuPA2025 who allowed me to share our recent results with the community, and who did a fantastic job putting together such a great conference of nearly 500 people in a location most of us only dream about visiting.
erwinschoof.bsky.social
Big shout out to my lab who enabled me to present some of the cool stuff they spend their valuable energy on, to #DTUBioengineering for hosting our efforts, and my funders for funding our work.
erwinschoof.bsky.social
On my way home from what was an absolute blast of a EuPA2025 in the lovely Saint-Malo in France. So much great science, amazing people, old & new friends, and not the least, our valuable tech partners. The future of proteomics is clearly still only beginning & we all seem to be enjoying the ride! :)
erwinschoof.bsky.social
Thanks for the share and update - we certainly benefit from all the amazing tech in scp-MS!
Reposted by Erwin Schoof
ionopticks.bsky.social
The year of "How deep can we go?"
Erwin Schoof presents a view of the deepest proteome coverage across various cell types at #EuPA2025, using the newly released Orbitrap Astral Zoom. Analysing 40 HEK2983T cells per day, using an Aurora Ultimate 25x75 will consistently get you ~6,000 protein IDs.