Ethan Goddard-Borger
@ethangbaus.bsky.social
Glycobiology | Chemical Biology | Drug Development
Prof @ Walter and Eliza Hall Institute, Melbourne, Australia
Prof @ Walter and Eliza Hall Institute, Melbourne, Australia
Reposted by Ethan Goddard-Borger
🎉 Congratulations to our 2026 AGS EMCR Award winners! 🎉
🏅 Protein Metrics ECR Awardee - Dr Jonathan Du
🏅 SHIMADZU MCR Awardee - Prof Morten Andersen
Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org
A huge thanks to our sponsors for supporting these awards 👏
🏅 Protein Metrics ECR Awardee - Dr Jonathan Du
🏅 SHIMADZU MCR Awardee - Prof Morten Andersen
Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org
A huge thanks to our sponsors for supporting these awards 👏
December 18, 2025 at 9:21 PM
🎉 Congratulations to our 2026 AGS EMCR Award winners! 🎉
🏅 Protein Metrics ECR Awardee - Dr Jonathan Du
🏅 SHIMADZU MCR Awardee - Prof Morten Andersen
Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org
A huge thanks to our sponsors for supporting these awards 👏
🏅 Protein Metrics ECR Awardee - Dr Jonathan Du
🏅 SHIMADZU MCR Awardee - Prof Morten Andersen
Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org
A huge thanks to our sponsors for supporting these awards 👏
Reposted by Ethan Goddard-Borger
The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb
December 16, 2025 at 10:12 AM
The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb
Reposted by Ethan Goddard-Borger
Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions
Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
go.nature.com
December 16, 2025 at 4:55 PM
Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions
Reposted by Ethan Goddard-Borger
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice
HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.
www.science.org
November 19, 2025 at 7:04 PM
Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...
Reposted by Ethan Goddard-Borger
The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...
#ChemNobel #Chem #Chemistry #chemsky 🧪
#ChemNobel #Chem #Chemistry #chemsky 🧪
The 2025 chemistry Nobel goes to MOFs
Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks
cen.acs.org
October 8, 2025 at 10:12 AM
The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...
#ChemNobel #Chem #Chemistry #chemsky 🧪
#ChemNobel #Chem #Chemistry #chemsky 🧪
Reposted by Ethan Goddard-Borger
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
October 6, 2025 at 9:27 PM
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
Reposted by Ethan Goddard-Borger
Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase
O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...
chemrxiv.org
October 7, 2025 at 6:10 AM
Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Reposted by Ethan Goddard-Borger
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
September 28, 2025 at 9:16 PM
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
Reposted by Ethan Goddard-Borger
Reposted by Ethan Goddard-Borger
Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social
September 3, 2025 at 10:00 AM
Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social
Reposted by Ethan Goddard-Borger
Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.
🔗 www.wehi.edu.au/news/eureka-...
🔗 www.wehi.edu.au/news/eureka-...
September 3, 2025 at 9:54 PM
Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.
🔗 www.wehi.edu.au/news/eureka-...
🔗 www.wehi.edu.au/news/eureka-...
Reposted by Ethan Goddard-Borger
The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!
Director, Centre for Chemistry and Drug Discovery
Institute for Molecular Bioscience Join a university ranked in the world’s top 50 Australia’s #1 research institute Based at St Lucia Campus About UQ What started as Queensland's first university in 1...
uq.wd3.myworkdayjobs.com
September 2, 2025 at 2:46 AM
The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!
Reposted by Ethan Goddard-Borger
Last but most certainly not least, The President’s Innovator Award 2025 goes to
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂
August 13, 2025 at 3:59 AM
Last but most certainly not least, The President’s Innovator Award 2025 goes to
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂
Reposted by Ethan Goddard-Borger
#glycotime #immunology Structure-guided design rules for antibodies targeting cancer antigens with Tn and STn epitopes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context - Nature Chemical Biology
Structural studies of certain Tn and STn antigen-targeting antibodies reveal that their VH and VL domains recognize the glycan antigen and the adjacent peptide region, respectively, enabling a VH doma...
www.nature.com
August 1, 2025 at 7:50 PM
#glycotime #immunology Structure-guided design rules for antibodies targeting cancer antigens with Tn and STn epitopes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ethan Goddard-Borger
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
PINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific Research
YouTube video by Australian Museum
www.youtube.com
July 31, 2025 at 12:00 AM
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Reposted by Ethan Goddard-Borger
ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...
July 24, 2025 at 2:44 AM
ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...
Reposted by Ethan Goddard-Borger
Introducing Latent-X — our all-atom frontier AI model for protein binder design.
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
July 22, 2025 at 6:21 AM
Introducing Latent-X — our all-atom frontier AI model for protein binder design.
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
State-of-the-art lab performance, widely accessible via the Latent Labs Platform.
Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X
Reposted by Ethan Goddard-Borger
❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX
#CryoEM #apoptosis #mitochondria #BAX
June 27, 2025 at 4:33 AM
❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX
#CryoEM #apoptosis #mitochondria #BAX
Reposted by Ethan Goddard-Borger
New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org
June 12, 2025 at 8:20 AM
New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Ethan Goddard-Borger
Reposting - please consider applying for a lab head role @wehi-research.bsky.social in Australia. It is a wonderful place to work, in a great country and with lovely colleagues. Clearly I’m biased on all of those counts. Please repost and/or apply!
www.wehi.edu.au/careers/make...
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
Make your future Melbourne | WEHI
Lead the next wave of biomedical discovery
www.wehi.edu.au
June 4, 2025 at 9:22 AM
Reposting - please consider applying for a lab head role @wehi-research.bsky.social in Australia. It is a wonderful place to work, in a great country and with lovely colleagues. Clearly I’m biased on all of those counts. Please repost and/or apply!
Reposted by Ethan Goddard-Borger
🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery.
For more information and to apply 👇
For more information and to apply 👇
Make your future Melbourne
Lead the next wave of biomedical discovery
www.wehi.edu.au
May 15, 2025 at 7:03 AM
🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery.
For more information and to apply 👇
For more information and to apply 👇
Reposted by Ethan Goddard-Borger
www.wehi.edu.au/careers/make...
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
Make your future Melbourne | WEHI
Lead the next wave of biomedical discovery
www.wehi.edu.au
May 13, 2025 at 11:44 PM
www.wehi.edu.au/careers/make...
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social
Reposted by Ethan Goddard-Borger
Excited to share our new Nature Communications paper describing the molecular structure and the biochemical characterization of human #collagen #galactosyltransferase GLT25D1/COLGALT1 #glycotime www.nature.com/articles/s41...
Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1 - Nature Communications
Hydroxylysine galactosylation is essential for collagen maturation. This work reveals the molecular structure of human GLT25D1, its catalytic residues, and a noncatalytic structural domain stabilized ...
www.nature.com
April 16, 2025 at 7:17 PM
Excited to share our new Nature Communications paper describing the molecular structure and the biochemical characterization of human #collagen #galactosyltransferase GLT25D1/COLGALT1 #glycotime www.nature.com/articles/s41...
Reposted by Ethan Goddard-Borger
After 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bovine H5N1 binds poorly to human-type sialic acid receptors - Nature
Nature - Bovine H5N1 binds poorly to human-type sialic acid receptors
www.nature.com
April 16, 2025 at 6:40 PM
After 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ethan Goddard-Borger
Society for Glycobiology wishes to speak. www.glycobiology.org/index.php?op...
SFG Supports the Funding of Science
www.glycobiology.org
April 2, 2025 at 4:27 AM
Society for Glycobiology wishes to speak. www.glycobiology.org/index.php?op...