Title: Postdoctoral Associate Summary statement: The postdoctoral research associate is responsible for developing novel computational methodology for high-throughput sequence genomics tasks, as well ...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Carbon dioxide (CO2) assimilation by the enzyme Ribulose-1,5-bisphosphate Carboxylase/Oxygenase (Rubisco) underpins biomass accumulation in photosy...

The Department of Biology at UNC Chapel Hill (https://bio.unc.edu/) is searching to hire a tenure track Assistant Professor to study critical questions in Plant Molecular Biology.We seek candidates wh...

The success of plants on land has been enabled by mutualistic intracellular associations with microbes for 450 million years ([Delaux and Schornack 2021][1]). Because of their intracellular nature, th...

The success of plants on land has been enabled by mutualistic intracellular associations with microbes for 450 million years ([Delaux and Schornack 2021][1]). Because of their intracellular nature, th...

BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

The Department of Biology at the University of Massachusetts Amherst invites applications for a full-time, tenure-track Assistant Professor position in the area of Plant Physiology. The successful can...

Machine learning method counts nearly 12 million dead trees, many likely killed by rising seas

Humans and animals are ubiquitously colonized by Enterobacteriaceae , a bacterial family that contains both commensals and clinically significant pathogens. Here, we report Enterobacteriaceae megaplas...

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA viruses encode a distinct and functional IF4F translation initiation complex to drive protein synthesis, thereby blurring the line between cellular and acellular biology. During infection, eukaryotic IF4F on host ribosomes is replaced by an essential viral IF4F that regulates viral translation, virion formation, and replication plasticity during altered host states. Structural dissection of viral IF4F reveals that the mRNA cap-binding subunit mediates exclusive interactions with viral mRNAs, constituting a molecular switch from translating host to viral proteins. Thus, our study establishes that viruses express a eukaryotic translation initiation complex for protein synthesis, illuminating a series of evolutionary innovations to a core process of life. ### Competing Interest Statement The authors have declared no competing interest. Pew Biomedical Scholars Program G. Harold & Leila Y. Mathers Foundation, https://ror.org/02a7hjv13 National Institutes of Health, 1R35GM142527, 1DP2GM146250, F31NS132412 Parker Institute for Cancer Immunotherapy, https://ror.org/0184qbg02 European Research Council, 832601, 101160452 Branco Weiss Fellowship Moderna Therapeutics (United States), https://ror.org/01xm4wg91

Functional and genomic studies on the differences between the gametophyte and sporophyte life phases of plants remain scarce, yet unraveling these ...