Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

She is recognized for advancing the understanding of autoimmune diseases and bringing science into the public eye

Flt3L and CD40 agonism enhance dendritic cell immunosurveillance in human and murine pancreatic cancer and engage type I immunity.

Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...

Chen et al. demonstrate that DNASE1L3+ dendritic cells degrade neutrophil extracellular traps, thereby facilitating CD8+ T cell infiltration, effector function, and cytotoxic hub formation within the ...

Transcription factors are known to guide dendritic cell identity, but how they cooperate to drive lineage diversification remains unclear. Henriques-Oliveira, Altman, Kurochkin, et al. identify two tr...

Here Zhu et al. investigate the ontogeny of type 2 dendritic cells (DC2s) in mice. Using Klf4 expression to distinguish conventional DC precursors from plasmacytoid DCs, they identify two pre-DC2 popu...

A newly identified bacterial strain (YB328) isolated from the faeces of patients who responded to immune checkpoint blockade therapies can promote antitumour immunity through the activation of tumour-...

The induction of CD4+Foxp3+ regulatory T cells (pTreg cells) in the intestine is important for preventing allergic and inflammatory disease, but which…

Clark et al. reveal that tumor-derived cues induce a functional switch in tumor-associated macrophages (TAMs) through decreased expression of NDUFA4, a mitochondrial complex IV subunit. This promotes ...

Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...