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Reposted by Bret Freudenthal

Environmental Mutagenesis and Genomics Society @emgsus.bsky.social · 15d

Congratulations to our #EMGS2025 Best Oral Presentation Award Winners!

Best Student Oral Presentation
1st Place (Tied): David Schuster and Abigayle Vito
2nd Place: Foster Jacobs

Best Early Career Investigator Oral Presentation
1st Place: Elijah Newcomb
2nd Place: Lindsay Volk

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Jeremy Berg @jeremymberg.bsky.social · 7d

The fiscal year is over.

So how was the NIH appropriation committed?

A long thread with institute by institute results about where the money went.

a white cat is sitting on a box with the words where written on it .

ALT: a white cat is sitting on a box with the words where written on it .

media.tenor.com

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Jeremy Berg @jeremymberg.bsky.social · 9d

The fiscal year ends tomorrow.

Here are results from NIH Reporter downloaded an hour ago.

The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.

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$A graph showing the fraction of annual grant funding committed for NIH for fiscal years 2015 to 2025. The fiscal year 2025 lagged behind but then caught up over the last two months.$

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Bret Freudenthal @freudlab.bsky.social · 12d

Thanks so much!!

Bret Freudenthal @freudlab.bsky.social · 12d

Thanks to your incredible painting skills!

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Bret Freudenthal @freudlab.bsky.social · 13d

How it started: Assistant to the Professor 👨‍🔬✨

How it’s going: Professor mode unlocked 👨‍🏫

Also clear evidence that science doesn’t just build knowledge… it ages ya too. 😉

🙏Grateful to all the mentors, colleagues, trainees, friends & family who made this journey possible. I am here because you all!

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Bret Freudenthal @freudlab.bsky.social · 15d

… or is it a basement of a Wyoming “resident” in Jackson

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Bret Freudenthal @freudlab.bsky.social · 15d

I mean that seems to be the priorities, maybe we need a committee for these semi-pro “activities” to ensure proper training 🤣

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Jeremy Berg @jeremymberg.bsky.social · 16d

Here is a plot in terms of PROJECTS rather than dollars. I am using projects rather than awards so that projects that received supplements do not get double-counted.

While the FY25 curve is improving, it seems that the number of funded projects will drop by 3000-4000 compared with FY24.

A graph showing the number of projects funded per year by NIH for fiscal years 2021-2025. Fiscal year 2025 shows a reduction in the number of projects of approximately 3000-4000.

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Berna Devezer @devezer.bsky.social · 17d

i think regardless of who has authored a paper, we (the scientific community) can and should stop criticizing the work on lack of perceived novelty. we can do better than perpetuating harmful myths about individual scientific papers having to present a discovery no one has ever thought of before.

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Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Vijay Ramani @vram142.bsky.social · 18d

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

www.biorxiv.org

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Bret Freudenthal @freudlab.bsky.social · 17d

What an incredible @EMGSUS 2025 meeting last week! 🎉 Great science, community, and presentations. #EMGS2025

Special congrats to our lab members🏆 #proudPI:
Abbey Vito – 1st, Student Oral Presentation
Eli Newcomb – 1st, ECI Oral Presentation
Spencer Thompson – 2nd, Student Poster

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Environmental Mutagenesis and Genomics Society @emgsus.bsky.social · Sep 6

Are you a student, early career Investigator, or first time #EMGS meeting attendee?
Take part in the #EMGS2025 Quest to make sure you don’t miss anything and earn prizes along the way!
Start the Quest: form.jotform.com/251895711320...

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Bret Freudenthal @freudlab.bsky.social · Sep 5

Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out: www.jbc.org/article/S002...

APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis

Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during Base Excision Repair (BER). The enzyme apurinic/apyrimidinic endonu...

www.jbc.org

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Tony Cesare @thecesarelab.bsky.social · Aug 4

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

DNA-repair-driven cell death compels us to rethink cancer therapies - Nature Reviews Molecular Cell Biology

Emerging evidence suggests that, following genotoxic therapy, it is the repair of DNA double-strand breaks, rather than the damage itself, that frequently drives cancer cell death.

www.nature.com

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Josh Marshall @joshtpm.bsky.social · Aug 18

truly unreal. he's the guy who buys a lap dance and thinks the stripper and he had a deep connection

Aaron Rupar @atrupar.com · Aug 18

Trump on a hot mic on Putin: "I think he wants to make a deal for me. Do you understand? As crazy as it sounds."

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Bret Freudenthal @freudlab.bsky.social · Aug 15

Great catching up with Matt during his visit with @barneslab.bsky.social!

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Bret Freudenthal @freudlab.bsky.social · Aug 13

Congratulations Dr. Sowa! Such a great defense and project. Sara has a great lab and is doing wonderful work.

Sara N. Andres @structuresara.bsky.social · Aug 12

Congratulations Dr. Dana J. Sowa, our second PhD of the lab, and again, I'm so proud of all she has accomplished. A problem-solver and leader, wherever she lands next is going to be very lucky to have her! Thanks to her committee @gdwantibiotics.bsky.social @freudlab.bsky.social and Dr. Zhu.

Dr. Sowa at the traditional post-defense celebration, with her entry into the PhD words of wisdom book, adding "Your Science Matters".

Dr. Sowa with her examining committee, (L to R) Dr. Wright, Dr. Zhu, Dr. Freudenthal and Dr. Andres.

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Bret Freudenthal @freudlab.bsky.social · Aug 11

The summer just flew by this year and today is the first day of 5th grade for these two. Go get em boys. 🥹

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Bret Freudenthal @freudlab.bsky.social · Aug 4

Spencer Thompson gave a great talk at the @kucancercenter.bsky.social Cancer Biology symposium this past week. He has really got this talk looking clean and sounding clear. #proudPI @lumicks.bsky.social

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Bret Freudenthal @freudlab.bsky.social · Jul 12

Great way to end two summer student internships with the KUcancercenter symposium. Fantastic work by Carson Gray (undergrad) and Esther Solange (high school student)!

Kudos to Abbey Vito, Peyton Oden, and Justin Ling for being wonderful mentors.

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Ron Filipkowski @ronfilipkowski.bsky.social · Jul 1

In the past 24 hours, Trump’s threatened Elon Musk, Thomas Massie, Japan, a judge in Israel, the CEO of AT&T, Jerome Powell, Canada, Thom Tillis, a Forbes reporter, Harvard, & migrants with being eaten by Burmese pythons in the Everglades, while releasing a new line of colognes.

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Bret Freudenthal @freudlab.bsky.social · Jun 13

Congratulations Kaitlin Dehart on an outstanding PhD defense! I can’t believe another student has graduated from lab. #proudPI🥹

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Eric Topol @erictopol.bsky.social · Mar 10

Who funds biomedical research? @nature.com
www.nature.com/articles/d41...

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