Happy that @drmelaniew.bsky.social and I could play a small role in this lovely work led by @ssegurabayona.bsky.social. Please do give the preprint a look.

📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4

Lovely work Pragathi!

A shout out to lab member @szmyd-radoslaw.bsky.social for his recent recognition by @sydney.edu.au. Well earned Radek!

We’re proud of our researcher Dr Radek Szmyd who has received a 2025 University of Sydney Faculty of Medicine and Health Mid-Career Research Outstanding Publication Award - for Radek’s extraordinary work to understand why cancer cells die in different ways following radiotherapy.

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

DNA replication and Cryo-EM star Jacob Lewis is visiting @cmri.bsky.social today to present seminar. If you happen to be in Westmead, talk is 12:30 pm local time. See you there.

Excited to speak at the Hunter Meeting next week, alongside @cmri.bsky.social colleagues Pragathi Masamsetti (postdoc with Patrick Tam, proud Cesare lab alum) and Pengyi Yang (Head, Computational Systems Biology Unit). Looking forward to great science and good company.

www.huntermeeting.org.au

If you happen to be the the Oz Single Cell Conference this week in Sydney, check out @scientistkate.bsky.social's talk on Friday.

Kate is a joint postdoc w/@piptaberlay.bsky.social and will present her work on 3D Genome architecture and replication stress.

www.ozsinglecell.com

ACCM 2025! The Cesare lab will be there in force. Come join us in Melbourne for 3 days of amazing science.

I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org

Fantastic opportunity in Melbourne.

Hosting Lee Wong from @monashuniversity.bsky.social tomorrow to present her seminar: "Onco-histone mutations in paediatric high-grade glioma: molecular mechanisms and implications for therapy." If you are around @cmri.bsky.social tomorrow at 12:30, come by for a great talk.

@genomestability.bsky.social (Andrew Deans) will be @cmri.bsky.social tomorrow to present seminar at 12:30; "The Multifaceted Role of FANCM enzyme in DNA Repair and Cancer Therapy". If you are in the area, please do come by for a great talk.

Sorry Sam and @jenniferlovesecoli.bsky.social, I am also unaware of papers/studies exploring nuclear F-actin in c. elegans. Happy to be updated if anyone knows otherwise.

*basketball... 🤦‍♂️

My and @telomerase-cmri.bsky.social’s annual attempt to bring a little bit of college baseketball culture down under.

Go Tar Heels!

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬

📖 Free access: rdcu.be/edViW

Please 🔄 ❤️

🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR

26/Finally, the data are consistent with t-loops suppressing ATM activation by the chromosome end.

T-loops opening in a regulated and shelterin-dependent manner to signal cellular stress suggests a broader role for these chromosome end structures than previously appreciated.

25/We predict this represents a non-canonical telomere-dependent tumour suppressive activity outside the canonical ageing-dependent proliferative barriers imposed by telomere erosion.

Additionally, we found the protective functions of the TRF2 basic domain are mitosis specific.

24/What does this mean?

We now understand the pathway of MAD-telomere deprotection that contributes to 1) cell death during mitotic arrest, and 2) p53-dependent cell cycle arrest when cells escape an elongated mitosis.

23/Live imaging from both labs revealed that TRF2 mutants that suppress MAD-telomere deprotection also reduce the prevalence of mitotic arrest driven lethality. While TRF2 mutants that promote MAD-telomere deprotection enhanced mitotic death or expedited time of mitotic arrest to lethality.

22/Of note, telomeres do not rapidly truncate in MAD-telomere deprotection like they do when the TRF2 basic domain is deleted. Thus, while the TRF2 basic domain is modified to enable BTR-dependent t-loop opening, it does not allow t-loop junction cleavage, consistent with a highly regulated pathway.