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Takashi Fukaya

@fukayalab.bsky.social

920 followers 330 following 18 posts

Institute for Quantitative Biosciences, UTokyo. We study the mechanism of transcriptional regulation in the Drosophila embryo. https://sites.google.com/view/fukaya-lab-iqb/home

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Takashi Fukaya @fukayalab.bsky.social · Nov 11

How do distal enhancers control transcription dynamics in living cells? Check out our work published in
@MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. www.cell.com/molecular-ce...

Functional coordination between transcription factor clustering and gene activity

The dynamic assembly and disassembly of transcription factor (TF) clusters at enhancers is a major source of transcriptional bursting in developing Drosophila embryos. Formation of shared TF clusters ...

www.cell.com

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Reposted by Takashi Fukaya

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · Sep 8

Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!

FMI science @fmiscience.bsky.social · Sep 8

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

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Takashi Fukaya @fukayalab.bsky.social · Aug 31

Thanks Ito-san @itok10918.bsky.social for the great tour of New York!!

Takashi Fukaya @fukayalab.bsky.social · Aug 31

Fun visit to Rockefeller after the CSHL transcription meeting. It was great to catch up with Bob Roeder since his visit to Japan for the Kyoto Prize!

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Reposted by Takashi Fukaya

Nature @nature.com · Jul 7

Japan is the only country in the world that legally requires married couples to share the same family name

https://go.nature.com/4lfbXPL

Japan requires name change after marriage — with big effects on female scientists

Nature - Survey finds law requiring married couples to share the same family name causes havoc for researchers.

go.nature.com

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Takashi Fukaya @fukayalab.bsky.social · Jul 6

Delighted to share a new review paper from the lab. We summarized/discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra.bsky.social for this opportunity!!

www.sciencedirect.com/journal/jour...

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Reposted by Takashi Fukaya

Grace Bower @gracebower.bsky.social · Jul 2

A dream come true: my first first-author publication! 🧬 🎉 Working to unravel the mysteries of long-range gene regulation has been an incredible journey. Endless gratitude to Evgeny, the lab, and all of the amazing collaborators who helped make this happen 🙌

Evgeny Kvon @evgenykvon.bsky.social · Jul 2

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

Range extender mediates long-distance enhancer activity - Nature

The REX element is associated with long-range enhancer–promoter interactions.

www.nature.com

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Takashi Fukaya @fukayalab.bsky.social · Jun 28

Looks like I’m going to miss my flight from Frankfurt to Tokyo because of a delay at Basel airport🥺

Takashi Fukaya @fukayalab.bsky.social · Jun 27

Thanks Luca @lucagiorgetti.bsky.social for hosting me at FMI. It was absolutely a fun visit and I got many nice feedback!

Takashi Fukaya @fukayalab.bsky.social · Jun 26

Giving a seminar at FMI Basel tomorrow! Looking forward to it!!

Reposted by Takashi Fukaya

Mannervik Lab @mannerviklab.bsky.social · Jun 18

Curious about epigenetics, gene regulation, and developmental biology?
Apply for the PhD position in Mannervik lab at Stockholm University!
We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development. Explore the chromatin landscape with us!

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Takashi Fukaya @fukayalab.bsky.social · Jun 20

Look forward to visiting University of Lausanne next week!

Takashi Fukaya @fukayalab.bsky.social · May 25

Pachypodium gracilius has finally bloomed with yellow flowers after seven years of growing it from seed.

パキポディウムグラキリス、種から育てて7年、黄色い花が咲きました。

Takashi Fukaya @fukayalab.bsky.social · May 22

Delighted to share a new preprint from the lab!

We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila.
www.biorxiv.org/content/10.1...

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Reposted by Takashi Fukaya

Anton Goloborodko @golobor.bsky.social · Apr 11

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...

Rules of Engagement

YouTube video by Johan Gibcus

www.youtube.com

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Takashi Fukaya @fukayalab.bsky.social · Apr 13

Nice to catch up with Luca @lucagiorgetti.bsky.social in Tokyo!

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Reposted by Takashi Fukaya

Hilgers Lab @hilgerslab.bsky.social · Mar 14

So excited to host my friend and former labmate @laghalab.bsky.social as a ... (drumroll) Special Guest at our institute! Mark your calendars and expect a great talk with beautiful live imaging.

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Mar 13

We are excited. Mounia Lagha will be our 1st Special Guest in 2025.🤗

📆 March 20, 1pm

The Lagha lab (@igmm-montpel.bsky.social) uses live imaging to study mechanisms of transcription & translation in living embryos. Join us for an enlightening talk next Thursday.
(Host: @hilgerslab.bsky.social)

Seminar announcement for a Max Planck Special Guest Seminar featuring Mounia Lagha from IGMM, France. The talk, titled 'Lighting Up the Central Dogma to Dissect How Sharp Developmental Patterns Are Established,' is scheduled for March 20, 2024, at 1:00 PM at MPI-IE, Lecture Hall in Freiburg.

The Lagha lab investigates the mechanisms governing gene expression during development, focusing on the interplay between transcription and translation. They pioneered methods to study the translation of single mRNA molecules in Drosophila embryos, revealing critical heterogeneity in translation. This work has led to the discovery of translation factories and intragenic translation heterogeneity, uncovering a novel layer of variation in gene expression.
To achieve a comprehensive understanding of gene expression precision, the Lagha Lab integrates transcriptional and translational regulation. They employ advanced quantitative imaging techniques to simultaneously monitor mRNA and protein dynamics in living Drosophila embryos with high spatio-temporal resolution. These observations are combined with theoretical models to formulate predictions, which are then tested through genetic and optogenetic manipulations. The lab's research aims to bridge the gap between transcription and translation, providing an integrated, multiscale view of gene expression control.

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Reposted by Takashi Fukaya

Rada-Iglesias Lab @radaiglesiaslab.bsky.social · Mar 10

Only one week left to submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies". Submit now and present your latest work in one of our short talks.

Rada-Iglesias Lab @radaiglesiaslab.bsky.social · Jan 31

Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21).

Book the dates and register soon!!!

meetings.embo.org/event/25-enh...

Enhancer Mechanics and Enhanceropathies

Join us for the highly anticipated third EMBO workshop on Enhancer Mechanics and Enhanceropathies! Building on the success of our previous meetings in Santander (2021) and Marseilles (2023), this eve…

meetings.embo.org

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Takashi Fukaya @fukayalab.bsky.social · Mar 6

It was great to see my long-time friend from graduate school, Takashi Akera
@takashiakeralab.bsky.social

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Reposted by Takashi Fukaya

Rada-Iglesias Lab @radaiglesiaslab.bsky.social · Mar 3

Do you have an exciting story about #enhancers or #enhanceropathies?. Then submit your abstract to the @embo.org workshop on "Enhancer mechanics and Enhanceropathies" in Denmark before is too late: the deadline for abstract submissions is in two weeks (March 17th)!

meetings.embo.org/event/25-enh...

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Reposted by Takashi Fukaya

Naomichi Takemata @naomichitakemata.bsky.social · Feb 19

Excited to share our work on archaeal 3D genome! This paper revealed how an archaeal SMC complex sculpts TAD-like domains by cooperating with a roadblock NAP and physical properties of DNA. Many congrats to our talented PhD student Kodai!
www.nature.com/articles/s41...

Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure - Nature Communications

Eukaryotic chromosomes are organized into arrays of compact domain structures called TADs. Here the authors show that a member of the Archaea, the prokaryotic domain closest to the Eukarya, uses a euk...

www.nature.com

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Reposted by Takashi Fukaya

@tim_stasevich @tim-stasevich.bsky.social · Feb 12

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...

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Reposted by Takashi Fukaya

Mir Lab @mirlab.bsky.social · Feb 12

1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...

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Takashi Fukaya @fukayalab.bsky.social · Feb 9

Looking forward to it!! Abstract submission deadline: 17 March 2025.

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Takashi Fukaya @fukayalab.bsky.social · Feb 3

Job alert: My collaborator, Camilla Björkegren at Karolinska Institutet, is looking for a postdoc to study the mechanisms of chromosome organization!
ki.varbi.com/en/what:job/...

Postdoctoral Researcher in chromosome organization and function

Do you want to contribute to top quality medical research? Join the lab of Camilla Björkegren at the Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden, to study molec

ki.varbi.com

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Reposted by Takashi Fukaya

Mariko Sasaki @marikosasakiatnig.bsky.social · Jan 29

Hello Bluesky. For my first post here, I am happy to share that our paper is finally out in Nucleic Acids Research, highlighting how collision between transcription machinery and arrested replication fork triggers circular rDNA formation in budding yeast.

academic.oup.com/nar/article/...

Transcription near arrested DNA replication forks triggers ribosomal DNA copy number changes

Abstract. DNA copy number changes via chromosomal rearrangements or the production of extrachromosomal circular DNA. Here, we demonstrate that the histone

academic.oup.com

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