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Reposted by Mariko Sasaki

eric lai @lucksmith.bsky.social · 21d

congratulations to our DB colleague Maria Jasin, recognized by the Greengard Prize! when she started her lab @mskcancercenter.bsky.social, she was the first to insert DNA into a defined location of a mammalian genome! her work underlies today's CRISPR-mediated HDR. here in convo with Rick Lifton.🧬

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Reposted by Mariko Sasaki

The Rockefeller University @rockefeller.edu · 26d

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience

Developmental biologist Maria Jasin wins the 2025 Pearl Meister Greengard Prize - News

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Awarded annually by ...

www.rockefeller.edu

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Reposted by Mariko Sasaki

Yasu Daigaku @yasudaigaku.bsky.social · 26d

Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis.
www.biorxiv.org/content/10.1...

Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis.

Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (P...

www.biorxiv.org

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MSKEducation @mskeducation.bsky.social · 23d

While our judges deliberate the top 3 winners of MSK Postdoc Slam, let’s celebrate our #NPAW2025 📸 contest champs! 🎉
🥇 @meganekelley.bsky.social – @agnelsfeir.bsky.social lab
🥈 Zhendong Cao – @sawyerslabmskcc.bsky.social
🥉 Manendra Lankadasari – Jones lab
Congrats to our amazing #MSKPostdocs! 👏📷

NPAW 2025 photo contest winners
Penni for our thoughts - Megan E. Kelley (Sfeir Lab)
May your generating station for science never stop, and may it kiss the skyline with a touch of beauty - Zhendong Cao (Sawyers Lab)
Who needs WiFi when the universe is streaming live above your tent? - Manendra Lankadasari (Jones Lab)

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Peter Ly @peterlylab.bsky.social · 28d

Excited to join the @cri-utsw.bsky.social community to advance discoveries in genome instability. We are grateful to UTSW Pathology for 6 wonderful years.

🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!

Children's Research Institute at UT Southwestern @cri-utsw.bsky.social · 28d

WELCOME to the Institute, @peterlylab.bsky.social! Dr. Ly studies how cells maintain genomic integrity and how dysregulation of these processes impacts human health. 🧪Learn more about his research 👉 cri.utsw.edu/faculty/pete... #relentlessdiscovery

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Fusion Conferences @fusionconf.bsky.social · Feb 13

#ecDNA is reshaping biomedical science. Now recognized as a key player in ~30% of cancer patients, understanding its biology could unlock new therapeutic strategies for #cancer & other diseases. Join us at #ecDNA25 for discussions at the forefront of this rapidly advancing field ➡️ bit.ly/XecDNA25

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Fusion Conferences @fusionconf.bsky.social · Mar 27

🎉 Exciting News! 🎉
Registration grants have been released to support ECR's attending #ecDNA25! Don't miss the chance to engage with cutting-edge research & connect with experts in the field.
🌟Find out more: bit.ly/XecDNA25

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Reposted by Mariko Sasaki

Fusion Conferences @fusionconf.bsky.social · Apr 28

Early bird & talk submission close on 01 May 2025 for #ecDNA25!
🧬 Join us in Riviera Maya for a packed program featuring top speakers & cutting-edge science
💰 Travel grants available
🎉 Bonus: it’s Día de los Muertos - experience the Mexican culture!
Register & submit: bit.ly/3YmCmBY

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Agnel Sfeir @agnelsfeir.bsky.social · Mar 10

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

Engineering mtDNA deletions by reconstituting end joining in human mitochondria

Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…

www.sciencedirect.com

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · Mar 7

Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

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Naama Aviram @naamaaviram.bsky.social · Mar 3

Here we go!
#newPI #WomenInSTEM

@mskeducation.bsky.social @mskcancercenter.bsky.social

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Dirk Remus @dirkremus.bsky.social · Mar 6

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation

DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

www.science.org

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Corentin Claeys Bouuaert @ccb-lab.bsky.social · Feb 19

Also see two accompanying papers by the labs of Scott Keeney and Ming-Han Tong reporting similar findings, focusing on the SPO11-TOP6BL complex.
www.nature.com/articles/s41...
www.nature.com/articles/s41...

And here is a nice News&views by Mendez Diaz and Corbett.
www.nature.com/articles/d41...

Reconstitution of SPO11-dependent double-strand break formation - Nature

Reconstitution of recombinantly expressed SPO11–TOP6BL complex recapitulates its DNA cleavage function and together with structural modelling and biochemical experiments, provides insights into the re...

www.nature.com

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Reposted by Mariko Sasaki

The Groth lab @grothlab.bsky.social · Feb 19

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

tinyurl.com

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · Feb 20

Our new review on how the #chromatin domain is formed in the cell is now available @Curr Opin Struct Biol.📄✨
We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation.
📥 Free-download link:
authors.elsevier.com/a/1keGn,LqAr...

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Corentin Claeys Bouuaert @ccb-lab.bsky.social · Feb 19

🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...

SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro - Nature

A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently atta...

www.nature.com

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Di Jiang @dijiang319.bsky.social · Feb 8

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Protein codes promote selective subcellular compartmentalization

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

www.science.org

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Takashi Fukaya @fukayalab.bsky.social · Feb 3

Job alert: My collaborator, Camilla Björkegren at Karolinska Institutet, is looking for a postdoc to study the mechanisms of chromosome organization!
ki.varbi.com/en/what:job/...

Postdoctoral Researcher in chromosome organization and function

Do you want to contribute to top quality medical research? Join the lab of Camilla Björkegren at the Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden, to study molec

ki.varbi.com

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Reposted by Mariko Sasaki

HunterLab.bsky.social @hunterlab.bsky.social · Jan 31

Sadly, our colleague and friend Scott Hawley passed away this morning. He was an irreplaceable presence and force for good in the meiosis an Drosophila communities and will be sorely missed.

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Soni Lacefield @lacefieldlab.bsky.social · Jan 31

Feeling very lost today with the news of the passing of my undergrad advisor Scott Hawley. He had a huge impact on the field and on me personally. He was the first person to see me as a scientist and gave me the confidence to apply to grad school. I am so grateful to be a part of his legacy.

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MAYosis @mayosis.bsky.social · Jan 31

We are deeply sadden by the sudden loss of Scott. He was an astounding mentor and brought so much to the community on top of his excellent science. His legacy will live on
#Meiosis4ever

HunterLab.bsky.social @hunterlab.bsky.social · Jan 31

Sadly, our colleague and friend Scott Hawley passed away this morning. He was an irreplaceable presence and force for good in the meiosis an Drosophila communities and will be sorely missed.

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Reposted by Mariko Sasaki

Anton Henssen @anton-henssen.bsky.social · Jan 31

Exciting new paper 🔥🔥👇🏻👇🏻

Sudarshan Pinglay @sudpinglay.bsky.social · Jan 31

Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.

www.science.org/doi/10.1126/...

Multiplex generation and single-cell analysis of structural variants in mammalian genomes

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

www.science.org

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Di Jiang @dijiang319.bsky.social · Feb 1

@science.org Genome recombination on demand | Science www.science.org/doi/10.1126/... a Perspective by @seczmarta.bsky.social Lars Steinmetz @stanford.edu on two studies bit.ly/4hzFRMg + bit.ly/4jyT4Hf that generate large genome rearrangements in mammalian cells @ unprecedented scale #synbio #genome

Genome recombination on demand

Large genome rearrangements in mammalian cells can be generated at scale

www.science.org

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Mariko Sasaki @marikosasakiatnig.bsky.social · Jan 29

Thank you!

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