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Anton Henssen @anton-henssen.bsky.social · 1d

So nice to see our work out in print! Very special to have two of our eDyNAmiC papers in the same issue. What a beautiful cover! Thank you @elizsmckenna.bsky.social !! @aacrjournals.bsky.social

Elizabeth McKenna @elizsmckenna.bsky.social · 2d

The October issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features two papers on the role of #ecDNA heterogeneity in tumor evolution and adaptation to therapy - you can find these papers and much more here: aacrjournals.org/cancerdiscov...

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Anton Henssen @anton-henssen.bsky.social · 14d

Thank you for inviting me to talk alongside Ido about our work on ecDNA!

CompCancer PhD programme @compcancer.bsky.social · 14d

We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!

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Reposted by Anton Henssen

Elizabeth McKenna @elizsmckenna.bsky.social · Aug 13

Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...

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Reposted by Anton Henssen

Cancer Research Horizons @crhorizons.bsky.social · Jul 11

A huge thank you to all #IEAwards25 winners and nominees for an inspiring evening. We can’t wait to see what’s next on your horizon.

Read more: bit.ly/44m94a0

#OnMyHorizon @anton-henssen.bsky.social, @nnennayakanu.bsky.social, @michellecruk.bsky.social @timwitney.bsky.social, @cuh.nhs.uk

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Reposted by Anton Henssen

Benjamin Werner @benjaminwerner.bsky.social · Aug 8

I am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social.

@anton-henssen.bsky.social @cancergrand.bsky.social

aacrjournals.org/cancerdiscov...

Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

AbstractExtrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance throug...

aacrjournals.org

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Reposted by Anton Henssen

Fusion Conferences @fusionconf.bsky.social · May 14

@anton-henssen.bsky.social we are looking forward to your presentation at #ecDNA25 in Mexico! Please share with your followers to let them know our early bird registration & talk submission close on 02 June 2025!
💰Grants available
✅More info: bit.ly/42XY0za

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Reposted by Anton Henssen

Charlotte Brierley @ckbrierley.bsky.social · Jun 10

🚨🚨Paper out! 🚨🚨

Delighted to share our work, now published in ‪@natgenet.nature.com‬ 🧬!
shorturl.at/94s5S

We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n

Illustration: Hratch Arbach
🧵👇

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Anton Henssen @anton-henssen.bsky.social · Apr 5

Congrats Juliane and Monika authors.elsevier.com/sd/article/S...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

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Reposted by Anton Henssen

Lorenzo de la Rica @ldelarica.bsky.social · Mar 11

New @theaacr.bsky.social Cancer Discovery paper on ecDNA in urothelial carcinoma reveals how ecDNAs:
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...

Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and Tumor-Immune Microenvironment

Abstract. Extrachromosomal DNA (ecDNA) presents a promising target for cancer therapy; however, its spatial-temporal diversity and influence on tumor evolution and the immune microenvironment remain l...

aacrjournals.org

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Anton Henssen @anton-henssen.bsky.social · Feb 13

Great conference ! I look forward to attending. 🔥🔥👇🏻👇🏻

Fusion Conferences @fusionconf.bsky.social · Feb 13

#ecDNA is reshaping biomedical science. Now recognized as a key player in ~30% of cancer patients, understanding its biology could unlock new therapeutic strategies for #cancer & other diseases. Join us at #ecDNA25 for discussions at the forefront of this rapidly advancing field ➡️ bit.ly/XecDNA25

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Anton Henssen @anton-henssen.bsky.social · Jan 31

Congrats !! Great work

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Anton Henssen @anton-henssen.bsky.social · Jan 31

Exciting new paper 🔥🔥👇🏻👇🏻

Sudarshan Pinglay @sudpinglay.bsky.social · Jan 31

Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.

www.science.org/doi/10.1126/...

Multiplex generation and single-cell analysis of structural variants in mammalian genomes

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

www.science.org

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Anton Henssen @anton-henssen.bsky.social · Jan 23

Great conference with expert lineup ! I look forward to attending! 🔥🔥👇🏻👇🏻

Fusion Conferences @fusionconf.bsky.social · Jan 23

🧬🌟We're excited to add an Extrachromosomal Circular DNA conference to our 2025 calendar!🧬🌟
Chairs Birgitte Regenberg (Univ. of Copenhagen) & Zhao Zhang (Duke Univ.) are bringing a fantastic line up of speakers together in Mexico this year. More details➡️https://bit.ly/4az0PbV #ecDNA25 #eccDNA #ecDNA

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Anton Henssen @anton-henssen.bsky.social · Jan 18

It was a pleasure reviewing this article ! 👏🏻👏🏻

Reposted by Anton Henssen

Katie Houlahan @khoulahan.bsky.social · Jan 8

The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! www.nature.com/articles/s41...

Complex rearrangements fuel ER+ and HER2+ breast tumours - Nature

A study identifies three dominant genomic archetypes of breast cancer induced by discrete mutational processes, describing a continuum of genomic profiles and detailing the mechanisms underlying the p...

www.nature.com

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Anton Henssen @anton-henssen.bsky.social · Jan 3

👏🏻👏🏻👏🏻👏🏻

Reposted by Anton Henssen

Eli Van Allen @vanallenlab.bsky.social · Jan 2

Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids:
@danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org

www.science.org/doi/10.1126/...

Rare germline structural variants increase risk for pediatric solid tumors

Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using ge...

www.science.org

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Anton Henssen @anton-henssen.bsky.social · Jan 3

🔥🔥👇🏻👇🏻

Geoff Macintyre @gmaci.bsky.social · Jan 3

Want to know how inherited genome instability contributes to childhood cancers? Checkout this perspective from Jayne Hehir-Kwa and me www.science.org/doi/10.1126/... on the latest brilliant work from @vanallenlab.bsky.social www.science.org/doi/10.1126/... on rare germline SVs in paediatric cancers

Inherited genome instability

Germline structural variants are a risk factor for pediatric extracranial solid tumors

www.science.org

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Anton Henssen @anton-henssen.bsky.social · Jan 1

🔥🔥👇🏻👇🏻

Gaetano Gargiulo @ggargiul.bsky.social · Dec 31

End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?

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Anton Henssen @anton-henssen.bsky.social · Dec 21

Important work by Heribert Jürgens and colleagues on how telemedicine can improve the management of patients suffering from sarcoma. 👏🏻👏🏻👇🏻👇🏻

www.sciencedirect.com/science/arti...

www.sciencedirect.com

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Anton Henssen @anton-henssen.bsky.social · Dec 19

80%

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Anton Henssen @anton-henssen.bsky.social · Dec 18

Congrats !! Such a great achievement ! 👏🏻👏🏻🔥🔥

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Anton Henssen @anton-henssen.bsky.social · Dec 18

Major milestone in ecDNA research!!! 👏🏻👏🏻👏🏻🔥🔥🔥👇🏻👇🏻

AndreaVenturaLab @andreaventura.bsky.social · Dec 18

🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...

Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

www.nature.com

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Reposted by Anton Henssen

Possu Huang Lab @possuhuanglab.bsky.social · Dec 17

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens

TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk

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Reposted by Anton Henssen

Mark Dawson @mafdawson.bsky.social · Dec 13

Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead!

www.biorxiv.org/content/10.1...

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia

Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genet...

www.biorxiv.org

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