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Reposted by Gaetano Gargiulo

Elizabeth McKenna @elizsmckenna.bsky.social · Aug 13

Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...

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Reposted by Gaetano Gargiulo

Chris Marine Lab @marinelab.bsky.social · Jun 18

Very excited to see our new study out today - just in time for my talk annual EACR conference @helloeacr.bsky.social

I-Mei @i-mei.bsky.social · Jun 18

Christophe Marine @marinelab.bsky.social @vib-ccb.bsky.social presenting his hot-off-the-presses Cancer Discovery paper today at #EACR2025!

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Reposted by Gaetano Gargiulo

EANO @eanoassociation.bsky.social · Jun 17

🚨We want your abstract! Submit your Late Breaking Abstract to #EANO2025 by June 25, 2025 to become an essential part of the state-of-the art scientific programme. 👉 Learn more: eano.eu/eano2025/abs... #NeuroOncology #NeuroSurgery #cancernurse #braintumor #btsm

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volker hovestadt @hovestadt.bsky.social · May 27

first post on bluesky, and it's a big one: our single-cell study on ETMR, a terrible brain tumor that occurs in young children, now out in @natcancer.nature.com: www.nature.com/articles/s43.... tremendous effort by @alexbeck, @lisagblr.bsky.social and many others. please check it out!

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer

Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

www.nature.com

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Gaetano Gargiulo @ggargiul.bsky.social · May 6

Glad to see this out, very helpful resource for the community!

Yahaya Yabo @yahayayabo.bsky.social · May 6

Finally, the GBmap paper is out after over 80 citations of the preprint version. Congratulations @ccruizm.bsky.social 🎉

Spencer S Watson @drspencerwatson.bsky.social · May 5

Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma!
doi.org/10.1093/neuo...

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Gaetano Gargiulo @ggargiul.bsky.social · Apr 8

Thanks for the invite, Alex! I really enjoyed both the chance to give a talk and the uniquely Swedish welcome, w/two Malmö goals included. Big relief I didn’t jinx it! 😅

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Christian Frezza @frezzalab.bsky.social · Mar 5

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity

www.nature.com/articles/s41...

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature

Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

www.nature.com

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Gaetano Gargiulo @ggargiul.bsky.social · Mar 6

"EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!

Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature

Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...

doi.org

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Gaetano Gargiulo @ggargiul.bsky.social · Feb 26

Understanding the basics is key to developing effective treatments. This framework on the myeloid side of brain tumors offers a systematic POV, with the dexa angle being particularly intriguing.

Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature

A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...

www.nature.com

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Reposted by Gaetano Gargiulo

Alessandro Filosa @alex-filosa.bsky.social · Feb 22

“We are almost ready for the test flight. All we need is the license." ...in Germany that may take much longer than developing and building the rocket 😂

Ars Technica @arstechnica.com · Feb 21

German startup to attempt the first orbital launch from Western Europe

“We are almost ready for the test flight. All we need is the license.”…

arstechnica.com

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Gaetano Gargiulo @ggargiul.bsky.social · Feb 22

🤣🤣🤣

Gaetano Gargiulo @ggargiul.bsky.social · Feb 22

Above all, I find it incredibly inspiring that a scientist with four decades of groundbreaking work is still leading discoveries, firsthand, literally. For some, curiosity and rigor never age. This one is special 👏

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Gaetano Gargiulo @ggargiul.bsky.social · Feb 22

Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.

RNA polymerase II at histone genes predicts outcome in human cancer

Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...

www.science.org

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Reposted by Gaetano Gargiulo

Di Jiang @dijiang319.bsky.social · Feb 16

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

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Reposted by Gaetano Gargiulo

Anders H. Lund @andershlund.bsky.social · Feb 20

🔬 #FundamentalResearch is key for #EUcompetitiveness

EU-LIFE @eu-life.bsky.social · Feb 20

🔬 #FundamentalResearch is key for #EUcompetitiveness and to address global societal challenges 🌍 #Innovation leaders from the #biotech sector highlight the crucial role of #research for their work ⬇️

Since 2014, EU-LIFE institutes have contributed to #EU innovation ecosystem with over 80 #startups!

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Reposted by Gaetano Gargiulo

Trudy G. Oliver @tgoliver.bsky.social · Feb 20

Someone finally said it out loud.

Karly Kingsley @karlykingsley.bsky.social · Feb 20

“After we’ve discriminated against, deported, or disparaged all the immigrants, the gay and lesbian and transgender people, the developmentally disabled, the women, and minorities. Once we’ve ostracized our neighbors and betrayed our friends… what comes next?” - Gov. JB Pritzker

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Reposted by Gaetano Gargiulo

Oded Rechavi @odedrechavi.bsky.social · Feb 20

Amazing

Nature @nature.com · Feb 20

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.

https://go.nature.com/41a7Zzj

Rare genetic disorder treated in womb for the first time

The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

go.nature.com

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Reposted by Gaetano Gargiulo

A.R. Moxon @juliusgoat.bsky.social · Feb 20

Normalize calling Republicans Nazis.

WuTangIsForTheChildren @wutangforchildren.bsky.social · Feb 20

🔥🔥🔥 Former Vikings punter Chris Kluwe was arrested for civil disobedience after speaking against a MAGA display that the city council of Huntington Beach agreed to put up at the public library…..that’s what’s up….every word👇

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Reposted by Gaetano Gargiulo

Michelle Monje @michellemonje.bsky.social · Feb 19

Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...

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Reposted by Gaetano Gargiulo

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Feb 17

1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.

Elizabeth McKenna @elizsmckenna.bsky.social · Feb 17

Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...

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Gaetano Gargiulo @ggargiul.bsky.social · Feb 18

Injectable fluorescent retro-tracing of pancreatic cancer innervation. Denervation sensitizes PDAC to immunotherapy by counteracting neuronal suppression of acute inflammation in CAFs. Plus, tumor denervation as a novel mechanism behind the old nab-paclitaxel combo. Quite a characterization indeed!

Victor Javier @vjsanchez.bsky.social · Feb 17

Characterization of single neurons reprogrammed by #PancreaticCancer 🧪 www.nature.com/articles/s41...

Characterization of single neurons reprogrammed by pancreatic cancer - Nature

Nature - Characterization of single neurons reprogrammed by pancreatic cancer

www.nature.com

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Gaetano Gargiulo @ggargiul.bsky.social · Feb 18

congrats Victor! Looking forward to reading it!

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Gaetano Gargiulo @ggargiul.bsky.social · Feb 14

Cell identity lives from constraints and dies from freedom

Moritz Mall @moritzmall.bsky.social · Feb 13

#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology

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Gaetano Gargiulo @ggargiul.bsky.social · Feb 12

Who knew they’d give you more than cavities? 😅 - great to see this on the cover @GuccioneLab!

GuccioneLab @guccionelab.bsky.social · Feb 12

What an amazing cover! Congrats @gloglita.bsky.social

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Gaetano Gargiulo @ggargiul.bsky.social · Feb 10

the synthetic locus control region for this study was designed using www.nature.com/articles/s41...

Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes - Nature Communications

Descriptive data in biomedical research are expanding rapidly, but functional validation methods lag behind. Here, authors present Logical Synthetic cis-regulatory DNA, a framework to design reporters...

www.nature.com