GalhardoLab
@galhardolab.bsky.social
Vasco Galhardo. Neuroscientist, Pain Research. Director PhD Program Neuroscience, University Porto. Group Leader i3S. Era-Net NEURON Ambassador.
Reposted by GalhardoLab
Cleta will get even madder if you read and share this article. So, please, don't do that...
www.democracydocket.com/news-alerts/...
www.democracydocket.com/news-alerts/...
Cleta Mitchell Thinks Trump Will Use Emergency Powers to Take Control of Elections
Read more here.
www.democracydocket.com
September 6, 2025 at 11:55 PM
Cleta will get even madder if you read and share this article. So, please, don't do that...
www.democracydocket.com/news-alerts/...
www.democracydocket.com/news-alerts/...
Reposted by GalhardoLab
A sea turtle surfacing by a MASSIVE school of rays near Clearwater, Florida a couple days ago. Another post into the BluSky void. Maybe 2 or 3 people will see this one and my time won't have been wasted. I'll keep trying a little longer. #nature #animals #amazing #wildlife #awesome #ocean
September 1, 2025 at 2:18 PM
Reposted by GalhardoLab
The first person to sequence a whale at single cell resolution is guaranteed a CNS paper. Then you'd need to sequence a family of whales.
July 15, 2025 at 9:57 AM
The first person to sequence a whale at single cell resolution is guaranteed a CNS paper. Then you'd need to sequence a family of whales.
Reposted by GalhardoLab
Reposted by GalhardoLab
That would be awful. Don’t share this.
May 31, 2025 at 1:17 AM
That would be awful. Don’t share this.
Reposted by GalhardoLab
Read the speech for yourself:
commencement.news.wfu.edu/2020s/c2025/...
ht: @brianstelter.bsky.social
commencement.news.wfu.edu/2020s/c2025/...
ht: @brianstelter.bsky.social
May 27, 2025 at 7:55 PM
Read the speech for yourself:
commencement.news.wfu.edu/2020s/c2025/...
ht: @brianstelter.bsky.social
commencement.news.wfu.edu/2020s/c2025/...
ht: @brianstelter.bsky.social
Reposted by GalhardoLab
In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge.
April 20, 2025 at 2:34 PM
In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge.
Reposted by GalhardoLab
Very elegant work, on a theme near and dear to me! Animals are individuals and their unique experiences matter for behavior and circuit recruitment/computation!
www.sciencedirect.com/science/arti...
(these two links are old stuff from me, beautiful new work from @marinopagan.bsky.social below!)
www.sciencedirect.com/science/arti...
(these two links are old stuff from me, beautiful new work from @marinopagan.bsky.social below!)
March 21, 2025 at 2:56 PM
Very elegant work, on a theme near and dear to me! Animals are individuals and their unique experiences matter for behavior and circuit recruitment/computation!
www.sciencedirect.com/science/arti...
(these two links are old stuff from me, beautiful new work from @marinopagan.bsky.social below!)
www.sciencedirect.com/science/arti...
(these two links are old stuff from me, beautiful new work from @marinopagan.bsky.social below!)
Reposted by GalhardoLab
The fact that we allow this absurd scientific publishing system to persist for decades, together with the insanely high percentage of precarious jobs in the academic system, proves we are not so smart after all...
March 20, 2025 at 7:42 PM
The fact that we allow this absurd scientific publishing system to persist for decades, together with the insanely high percentage of precarious jobs in the academic system, proves we are not so smart after all...
Reposted by GalhardoLab
New hope for families battling Dravet Syndrome.
Scientists have developed a new gene replacement therapy that could improve treatments for a rare and life-altering form of epilepsy. 🧵
#Neuroskyence #DravetSyndrome
Scientists have developed a new gene replacement therapy that could improve treatments for a rare and life-altering form of epilepsy. 🧵
#Neuroskyence #DravetSyndrome
March 19, 2025 at 6:33 PM
New hope for families battling Dravet Syndrome.
Scientists have developed a new gene replacement therapy that could improve treatments for a rare and life-altering form of epilepsy. 🧵
#Neuroskyence #DravetSyndrome
Scientists have developed a new gene replacement therapy that could improve treatments for a rare and life-altering form of epilepsy. 🧵
#Neuroskyence #DravetSyndrome
Reposted by GalhardoLab
In this week’s #PAIN Featured Image, Biggs et al. depict the functional connectivity of amygdala and hippocampus seed regions. Maps show FDR-corrected results. Cluster colors indicate seed region and clusters, and those that survived Bonferroni correction are circled. bit.ly/41eaqSo
March 19, 2025 at 5:00 PM
In this week’s #PAIN Featured Image, Biggs et al. depict the functional connectivity of amygdala and hippocampus seed regions. Maps show FDR-corrected results. Cluster colors indicate seed region and clusters, and those that survived Bonferroni correction are circled. bit.ly/41eaqSo
Reposted by GalhardoLab
Nice paper acceptance to start the week ⬇️ #PainResearch
It's pre-printed! Thrilled to finally share some human DRG proteomics, integrated across omics datasets to explore sexual dimorphism in the periphery 🧪🧬🖥️ #PainResearch #NeuroSkyence
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway
The peripheral nervous system has been widely implicated in pathological conditions that exhibit distinct clinical presentations in men and women, most notably in chronic pain disorders. Here, we expl...
www.biorxiv.org
March 18, 2025 at 8:00 AM
Nice paper acceptance to start the week ⬇️ #PainResearch
Reposted by GalhardoLab
and while you are at it, read this nice piece on mRNA vaccines for pancreatic treatment: www.mskcc.org/news/can-mrn... still early days on that, but what I have read about the approach is truly remarkable. Pancreatic cancer is a hellish disease.
March 17, 2025 at 8:48 PM
and while you are at it, read this nice piece on mRNA vaccines for pancreatic treatment: www.mskcc.org/news/can-mrn... still early days on that, but what I have read about the approach is truly remarkable. Pancreatic cancer is a hellish disease.
Reposted by GalhardoLab
OpenScope has been a game-changer in neuroscience and served as a shining example of #OpenScience. I'm incredibly proud of how this program has allowed important questions about the brain to be pursued and shared with the world.
Great questions can come from anywhere. OpenScope allows researchers from around the world to pitch experiments to be run – at not cost to them – in the Allen Brain Observatory. 🧠📈
🍿 youtu.be/13r9n0pSDLc
#BrainAwarenessWeek
🍿 youtu.be/13r9n0pSDLc
#BrainAwarenessWeek
OpenScope Impact
YouTube video by Allen Institute
youtu.be
March 14, 2025 at 10:02 PM
OpenScope has been a game-changer in neuroscience and served as a shining example of #OpenScience. I'm incredibly proud of how this program has allowed important questions about the brain to be pursued and shared with the world.
Reposted by GalhardoLab
The brain shapes our identity, memories, and emotions. Understanding it is key to combating brain diseases affecting over 3 billion people.
#BrainAwarenessWeek highlights the @alleninstitute.bsky.social's groundbreaking work. Let's raise awareness & inspire action for brain health. #ScienceMatters
#BrainAwarenessWeek highlights the @alleninstitute.bsky.social's groundbreaking work. Let's raise awareness & inspire action for brain health. #ScienceMatters
March 14, 2025 at 7:41 PM
The brain shapes our identity, memories, and emotions. Understanding it is key to combating brain diseases affecting over 3 billion people.
#BrainAwarenessWeek highlights the @alleninstitute.bsky.social's groundbreaking work. Let's raise awareness & inspire action for brain health. #ScienceMatters
#BrainAwarenessWeek highlights the @alleninstitute.bsky.social's groundbreaking work. Let's raise awareness & inspire action for brain health. #ScienceMatters
Reposted by GalhardoLab
Jane Yang et al.’s review finds that preclinical testing of NaV1.7-selective inhibitors aligned poorly with clinical testing, highlighting treatment regimen and choice of pain model as areas for improvement. Learn more in #PAIN bit.ly/3X2NO4P
March 12, 2025 at 5:00 PM
Jane Yang et al.’s review finds that preclinical testing of NaV1.7-selective inhibitors aligned poorly with clinical testing, highlighting treatment regimen and choice of pain model as areas for improvement. Learn more in #PAIN bit.ly/3X2NO4P
Reposted by GalhardoLab
Proud to have contributed to @jiaxuanqi.bsky.social's masterpiece out @nature.com! She shows that dopamine transients track the learned quality of song during juvenile learning and that dopamine release is driven not just by VTA firing, but by a local cholinergic mechanism! (1/x)
Dual neuromodulatory dynamics underlie birdsong learning - Nature
Dopamine release in the basal ganglia of the zebra finch is driven by neurons associated with reinforcement learning and by cholinergic signalling, and tracks performance quality during long-term lear...
www.nature.com
March 12, 2025 at 4:54 PM
Proud to have contributed to @jiaxuanqi.bsky.social's masterpiece out @nature.com! She shows that dopamine transients track the learned quality of song during juvenile learning and that dopamine release is driven not just by VTA firing, but by a local cholinergic mechanism! (1/x)
Reposted by GalhardoLab
Dendrite specific linking of memories over time - a cool extension of the work from @sjo09.bsky.social, @denisejcai.bsky.social, and others:
www.nature.com/articles/s41...
#neuroscience 🧪
www.nature.com/articles/s41...
#neuroscience 🧪
Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time - Nature Neuroscience
Sehgal et al. show that branch-specific dendritic plasticity mechanisms in the retrosplenial cortex link memories acquired close in time such that, unlike independent memories, linked memories are enc...
www.nature.com
March 11, 2025 at 2:02 PM
Dendrite specific linking of memories over time - a cool extension of the work from @sjo09.bsky.social, @denisejcai.bsky.social, and others:
www.nature.com/articles/s41...
#neuroscience 🧪
www.nature.com/articles/s41...
#neuroscience 🧪
Reposted by GalhardoLab
I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia.
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
March 11, 2025 at 2:30 PM
I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia.
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
Reposted by GalhardoLab
Accumulation of virtual tokens towards a jackpot reward enhances performance and value encoding in dorsal anterior cingulate cortex https://www.biorxiv.org/content/10.1101/2025.03.03.640771v1
March 10, 2025 at 5:16 PM
Accumulation of virtual tokens towards a jackpot reward enhances performance and value encoding in dorsal anterior cingulate cortex https://www.biorxiv.org/content/10.1101/2025.03.03.640771v1
Reposted by GalhardoLab
It is important for people to see this graph/data. #NIH is the irreplaceable leader of USA leadership in biomedical discovery and development of new therapeutics.
March 10, 2025 at 5:17 PM
It is important for people to see this graph/data. #NIH is the irreplaceable leader of USA leadership in biomedical discovery and development of new therapeutics.
Reposted by GalhardoLab
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️
March 9, 2025 at 4:00 PM
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️
Reposted by GalhardoLab
March 10, 2025 at 5:12 PM
Reposted by GalhardoLab
Wir brauchen einen “dreifachwumms”! Look at where the EU is (at the end of the chart) and tell me we could not do better.. This also shows you what a loss to science it was when the UK left the EU. Let’s work together.
March 10, 2025 at 7:13 PM
Wir brauchen einen “dreifachwumms”! Look at where the EU is (at the end of the chart) and tell me we could not do better.. This also shows you what a loss to science it was when the UK left the EU. Let’s work together.