georgelund.bsky.social
George Lund
@georgelund.bsky.social
250 followers 240 following 16 posts
Postdoc @Rothamsted in Microbial Natural Product Discovery. Microbial interactions (Pseudomonas & Zymoseptoria tritici), Bioinformatics, Secondary Metabolism.
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georgelund.bsky.social
George Lund @georgelund.bsky.social · Jun 3
🚨 New preprint!
We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat.
Available now on bioRxiv: doi.org/10.1101/2025...
Development of a bioassay guided genome mining approach for antifungal natural product discovery from pseudomonads
Zymoseptoria tritici causes Septoria Leaf Blotch disease of wheat and has evolved to overcome most chemical and genetic control methods. As such, new tools are required for future disease control. We...
doi.org
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Reposted by George Lund
marnixmedema.bsky.social
Marnix Medema @marnixmedema.bsky.social · Sep 8
We are looking for a 3-year postdoc to work with Daniel Probst, Justin van der Hooft and myself on an exciting project involving federated learning and integrative omics for discovery of new antibiotics from natural products.
Apply here: www.wur.nl/en/vacancy/p...
Please share!
www.wur.nl
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Reposted by George Lund
marnixmedema.bsky.social
Marnix Medema @marnixmedema.bsky.social · Sep 1
Now out as preprint: versions 2.0 of both BiG-SCAPE and BiG-SLiCE have been released! With significant speed and accuracy increases, as well as new interactive functionalities. www.biorxiv.org/content/10.1...
BiG-SCAPE 2.0 and BiG-SLiCE 2.0: scalable, accurate and interactive sequence clustering of metabolic gene clusters
Microbial metabolic gene clusters encode the biosynthesis or catabolism of metabolites that facilitate ecological specialization, mediate microbiome interactions and constitute a major source of medic...
www.biorxiv.org
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Reposted by George Lund
emmseveri.bsky.social
Emmanuele Severi @emmseveri.bsky.social · Aug 22
www.nature.com/articles/s41...

#microsky
Discovery of a widespread chemical signalling pathway in the Bacteroidota - Nature
The N-acyl-cyclolysine system regulates the expression of co-localized operons encoding diverse secreted molecules in Bacteroidota.
www.nature.com
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Reposted by George Lund
kostchristian.bsky.social
Christian Kost @kostchristian.bsky.social · Aug 22
Are you a theoretical biologist that is intererested in the ecology and evolution of metabolic interactions among microorganisms?

Do you like to cooperate with experimentalists?

Do you have a PhD and experience in modelling and statistics?

Then this position might be for you👇:

shorturl.at/iiiOv
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Reposted by George Lund
nicholahawkins.bsky.social
Nichola Hawkins @nicholahawkins.bsky.social · Aug 11
New paper out now in @britmycolsoc.org.uk Fungal Biology Reviews. Learning from fungicide resistance: Evolutionary insights to guide RNAi-based control of fungal crop pathogens. www.sciencedirect.com/science/arti...
Learning from fungicide resistance: Evolutionary insights to guide RNAi-based control of fungal crop pathogens
Crop protection against fungal pathogens is essential to prevent crop losses and maintain food security. Current crop protection relies heavily on che…
www.sciencedirect.com
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Reposted by George Lund
raufs.bsky.social
Rauf Salamzade @raufs.bsky.social · Jul 11
Great to see our manuscript on skDER & CiDDER - programs for selection of representative microbial genomes - now published.

Please give them a try and if you have any feature requests or issues, just let us know.

www.microbiologyresearch.org/content/jour...

github.com/raufs/skDER
skDER and CiDDER: two scalable approaches for microbial genome dereplication
An abundance of microbial genomes have been sequenced in the past two decades. For fundamental comparative genomic investigations, where the goal is to determine the major gain and loss events shaping...
www.microbiologyresearch.org
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Reposted by George Lund
gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · Jun 19
🎯 New antibiotic target in TB!
👉 Small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway.
👉 Effective vs drug-resistant Mycobacterium tuberculosis in vivo (in mice)
#TBSky #IDSky #MedSky 🧪
@nature.com
www.nature.com/articles/s41...
Targeting de novo purine biosynthesis for tuberculosis treatment - Nature
The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.
www.nature.com
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Reposted by George Lund
jellespooren.bsky.social
Jelle Spooren @jellespooren.bsky.social · Jun 17
Proud to share our latest pre-print manuscript entitled 'Downy mildew disease-suppressive soils transmit a protective core microbiome to the phyllosphere' (lnkd.in/dBk28gnT). Super cool to see the final chapter of my PhD at the Plant-Microbe Interactions group of Universiteit Utrecht now online!
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
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Reposted by George Lund
cenmag.bsky.social
C&EN (Chemical & Engineering News) @cenmag.bsky.social · Jun 11
In the past decade or so, new techniques have enabled a resurgence of antimicrobial discovery. A new golden age of antibiotics may be upon us, though getting a drug candidate into the clinic isn’t so easy: cen.acs.org/pharmaceutic... #chemsky 🧪
Bioprospectors mine microbial genomes for antibiotic gold
But turning what they find into drugs isn’t so easy
cen.acs.org
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georgelund.bsky.social
George Lund @georgelund.bsky.social · Jun 3
Big thanks to the team @Rothamsted, collaborators, and funders @BBSRC as part of the Growing Health Institute Strategic Programme.
Feedback welcome!
#preprint #microbiology #secondarymetabolites #genomemining #plantpathology
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georgelund.bsky.social
George Lund @georgelund.bsky.social · Jun 3
Our approach links in vitro antifungal activity with genome mining, enabling prioritisation of BGCs based on observed antagonism. This could help uncover novel biosynthetic gene clusters encoding secondary metabolites active against Z. tritici and other pathogens. 🌿🧬
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georgelund.bsky.social
George Lund @georgelund.bsky.social · Jun 3
Using genome sequencing + antiSMASH, we identified BGCs from antagonistic Pseudomonas strains, including one encoding the production of 2,4-diacetylphloroglucinol (2,4-DAPG).
Mutating phlD confirmed its role in antifungal activity. 🔬
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georgelund.bsky.social
George Lund @georgelund.bsky.social · Jun 3
💡 We found significant variation in Z. tritici sensitivity to bacterial antagonism —suggesting it could exist as a quantitative trait within natural Z. tritici populations.
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georgelund.bsky.social
George Lund @georgelund.bsky.social · Jun 3
We screened a panel of Pseudomonas isolates using a high-throughput in vitro antagonism assay against Z. tritici, enabling both qualitative and quantitative assessments of antifungal activity.
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georgelund.bsky.social
George Lund @georgelund.bsky.social · Jun 3
🚨 New preprint!
We've developed a bioassay-guided genome mining approach to identify bacterial secondary metabolites that inhibit Zymoseptoria tritici — a major fungal pathogen of wheat.
Available now on bioRxiv: doi.org/10.1101/2025...
Development of a bioassay guided genome mining approach for antifungal natural product discovery from pseudomonads
Zymoseptoria tritici causes Septoria Leaf Blotch disease of wheat and has evolved to overcome most chemical and genetic control methods. As such, new tools are required for future disease control. We...
doi.org
2 13 23
Reposted by George Lund
cryptogenomicon.bsky.social
Sean Eddy @cryptogenomicon.bsky.social · May 22
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
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Reposted by George Lund
jjjvanderhooft.bsky.social
Justin J.J. van der Hooft @jjjvanderhooft.bsky.social · May 20
#FERMO Prioritization of metabolite signals and metabolomics samples by streamlined data integration! 😎
#metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...
#ms2query #antismash #metabolomics #compmetabolomics #prioritization… | Justin J.J. van der Hooft
🚨 Preprint (update) alert 🚨 --> Prioritizing Metabolite Features with FERMO Very proud of Mitja Zdouc, PhD, Hannah Augustijn 😊👏, and all colleagues and collaborators involved: the FERMO preprint...
www.linkedin.com
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Reposted by George Lund
courtneyherms.bsky.social
Courtney Herms @courtneyherms.bsky.social · May 20
The best day ever!! Thank you so much to everyone who has been involved in this in project and came out to celebrate today. A moment I will never forget!
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nadineziemert.bsky.social
Nadine Ziemert @nadineziemert.bsky.social · May 13
Happy to announce that our „newest old tool“ autoMLST2.0 is out and published. You need an accurate and easy to use tool to build #phylogenetictrees from #bacterialgenomes: academic.oup.com/nar/advance-...
AutoMLST2: a web server for phylogeny and microbial taxonomy
Abstract. Accurate and accessible phylogenetic analysis is essential for understanding microbial taxonomy and evolution, which are integral to microbiology
academic.oup.com
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Reposted by George Lund
courtneyherms.bsky.social
Courtney Herms @courtneyherms.bsky.social · Apr 22
My 1st first-author research article is published in Applied Soil Ecology!
This paper has been my constant companion over the past 4 years, but I'm so happy to send it off into the world 👇
www.sciencedirect.com/science/arti...
Pseudomonas taxonomic and functional microdiversity in the wheat rhizosphere is cultivar-dependent and links to disease resistance profile and root diameter
Diversity within lower taxonomic units in microbial communities is a key trait, giving rise to important ecological functions. In the rhizosphere, the…
www.sciencedirect.com
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Reposted by George Lund
telatin.bsky.social
Andrea Telatin @telatin.bsky.social · Apr 10
Hello binfies 👋!

There is an open position for a senior bioinformatician to join our fab **core bioinformatics** team at @quadraminstitute.bsky.social.

jobs.quadram.ac.uk/Details.asp?...
Core Bioinformatics team at QIB -- job offer to join the team as bioinformatics programmer as per link
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georgelund.bsky.social
George Lund @georgelund.bsky.social · Mar 26
Happy to be back in Wageningen to join @marnixmedema.bsky.social, @jjjvanderhooft.bsky.social, @mmzdouc.bsky.social, & others for the Integrative Omics symposium—celebrating 10 years of genome mining & 5 years of metabolome mining at @WUR! #IntegrativeOmics #NaturalProductDiscovery
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danielcroll.bsky.social
Daniel Croll @danielcroll.bsky.social · Mar 25
@guidopuccetti.bsky.social, Gabriel Scalliet and I are excited to share our latest work.

Resistance in agriculture emerges fast, but we fail to grasp how the myriad mutations in pathogen populations contribute to this.

Please check out and share our latest preprint: www.biorxiv.org/content/10.1...
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Reposted by George Lund
markowenmartin.bsky.social
Mark O. Martin @markowenmartin.bsky.social · Feb 27
Thursday: time for #MattersMicrobial Episode #81! Dr. Marc Chevrette talks about genome mining, secondary metabolites, and why microbes are the very best chemists. Please share the #GoodMicrobialWord. @profvrr @wildtypeMC

youtu.be/QYGiAc4lRsk?...
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Reposted by George Lund
raufs.bsky.social
Rauf Salamzade @raufs.bsky.social · Feb 24
Our minireview on BGC evolution being shaped by genomic & ecological context is now live on mSystems:

journals.asm.org/doi/10.1128/...

#secmet #MEvoSky
Context matters: assessing the impacts of genomic background and ecology on microbial biosynthetic gene cluster evolution | mSystems
Microbial secondary metabolites are compounds produced by bacteria and fungi that are not required for their replication and unconditional survival (1, 2). While they are thus not expected to be unive...
journals.asm.org
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