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Reposted by Gwen Knight

Rein Houben @reinhouben.bsky.social · 1d

In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...

Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening

Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...

www.medrxiv.org

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Reposted by Gwen Knight

LSHTM AMR Centre @lshtmamrcentre.bsky.social · 26d

Sepsis claims a life every 3 seconds.

Ahead of #WorldSepsisDay, @jhenryc.bsky.social @lshtm.bsky.social shares 5 Facts × 5 Actions to tackle sepsis 🩺 & AMR 🦠—from empowering frontline workers 👩‍⚕️ to strengthening diagnostics 🔍 & integrating national response plans 🌍

👉 bit.ly/3Vh4NiG

World Sepsis Day 2025: 5 Facts x 5 Actions to tackle sepsis and antimicrobial

World Sepsis Day 2025: 5 Facts x 5 Actions to tackle sepsis and antimicrobial resistance | LSHTM

bit.ly

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Reposted by Gwen Knight

LSHTM AMR Centre @lshtmamrcentre.bsky.social · Jul 28

Congratulations to Jody Phelan for receiving the prestigious @esmyco.bsky.social Gertrud Meissner Award for his groundbreaking work on drug resistant tuberculosis 👏🌍

Read more 👉 bit.ly/4mfGDjW

Jody Phelan receives Gertrud Meissner Award | LSHTM

bit.ly

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Gwen Knight @gmknght.bsky.social · Jul 11

From this review by my PhD student Naomi Fuller: doi.org/10.1371/jour...

Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review

Author summary The emergence of drug-resistant tuberculosis (DR-TB), where the causative bacterium Mycobacterium tuberculosis is resistant to key antibiotics such as rifampicin and isoniazid, poses a ...

doi.org

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Gwen Knight @gmknght.bsky.social · Jul 11

Been thinking about bedaquiline resistance in TB a lot lately... and today I was wondering about other mathematical models... so I went back to this figure that I still love from a few years ago showing how in #AMR #TB modelling showing most is just RR-TB - lots to be done!

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Gwen Knight @gmknght.bsky.social · Jul 9

Unfortunately, we're going to have to reschedule this talk - if you have a free hour then do go back and check our some of our past seminars across the #AMR disciplines!

www.lshtm.ac.uk/research/cen...

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Gwen Knight @gmknght.bsky.social · Jul 8

Really looking forward to hear this high level overview of #AMR policy from a great female scientist!
Tomorrow - UK - lunch time 👩‍💻

LSHTM AMR Centre @lshtmamrcentre.bsky.social · Jun 9

🎙️ Join Prof Dame Sally Davies, for an insightful seminar on global action against AMR.

In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy.

📅 9 July 2025
🕰️ 13:00 BST
📍 Online
🔗 bit.ly/4kVSVgP

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Gwen Knight @gmknght.bsky.social · Jul 4

A Friday reminder of this talk next Wednesday.

I'm looking forward to welcoming our students to the @lshtm.bsky.social @lshtmamrcentre.bsky.social #AMR short course and then having this seminar from Prof Dame Sally Davies!

Gwen Knight @gmknght.bsky.social · Jun 10

Very excited for this event on the 9th July!

It's part of our #AMR short course but open to everyone as it's online. Do join in and here what the amazing Prof Dame Sally Davies has to stay on the current status of global action on #AMR! @lshtmamrcentre.bsky.social

LSHTM AMR Centre @lshtmamrcentre.bsky.social · Jun 9

🎙️ Join Prof Dame Sally Davies, for an insightful seminar on global action against AMR.

In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy.

📅 9 July 2025
🕰️ 13:00 BST
📍 Online
🔗 bit.ly/4kVSVgP

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Reposted by Gwen Knight

Katherine Horton @kchorton.bsky.social · Jul 4

In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.

doi.org/10.1016/S221...

@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social

Figure 1. Estimated number of trial endpoints in the control group of a prevention-of-disease vaccine trial in a high disease-burden setting showing number of endpoints on the y-axis and time in months on the x-axis. For bacteriologically confirmed symptomatic tuberculosis disease endpoints only, we estimate 69 endpoints, and for combined bacteriologically confirmed asymptomatic and symptomatic tuberculosis disease endpoints, we estimate 151 endpoints. Scenario assumes symptomatic disease incidence before trial screening of 300/100 000 per year and following 10 000 individuals over 3 years. Prevalent symptomatic and asymptomatic tuberculosis disease are screened out in month 0 and are not trial endpoints. Active screening occurs every 6 months for both scenarios and participants self-presenting with symptoms suggestive of tuberculosis disease would also be investigated.

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Reposted by Gwen Knight

London School of Hygiene & Tropical Medicine @lshtm.bsky.social · Jun 20

LSHTM's Director writes to UK Government about #Gaza public health catastrophe

Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:

👉 www.lshtm.ac.uk/newsevents/n...

Palestinians fleeing northern Gaza on 9 November 2023 amid Israel's bombardment and siege of the enclave, and intense fighting between the Israeli military and Hamas fighters in the north. Credit: Mohammed Zaanoun/TNH

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Reposted by Gwen Knight

Kat Holt @katholt.bsky.social · Jul 1

I'm super happy to share this preprint on ‘Distribution of capsule and O types in #Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage’
doi.org/10.1101/2025...

Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage

Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could aver...

doi.org

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Reposted by Gwen Knight

Michael Brockhurst @brockhurstlab.bsky.social · Jun 30

One week left to submit your abstract to @microbiologysociety.org meeting on “Understanding and Predicting Microbial Evolutionary Dynamics” at Liverpool 26-27 November

Lots of spaces for ECR talks and posters!
microbiologysociety.org/event/societ...

microbiologysociety.org

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Gwen Knight @gmknght.bsky.social · Jun 30

The complexity of #AMR is rarely understated but few studies tackle the selection vs. transmission challenge.

That's what makes this this analysis from 2020 led by @juliethebatgirl.bsky.social so great - look how much could be done with well linked hospital data ... doi.org/10.7554/eLif....

Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards

Patterns of antibiotic use and the connectivity between wards are independently associated with the incidence of antimicrobial-resistant infections in hospital networks.

doi.org

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Reposted by Gwen Knight

LSHTM AMR Centre @lshtmamrcentre.bsky.social · Jun 26

In this blog, our Student Liaison Officer @lshtm.bsky.social, Brandon Hill, explores the often-overlooked intersection between #AMR and #LGBTQ+ health, highlighting the need for more inclusive data and policies to address health inequities.

Read more 👇
bit.ly/3HYkp7e

Exploring the social determinants of AMR | LSHTM

bit.ly

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Gwen Knight @gmknght.bsky.social · Jun 24

Great to see this review of modelling for IPC & healthcare epi. - we had great discussions at the Think Tank!

Key points: determine pathway to infection, make sure the model fits to data then can use it to lead to evidence development on interventions 👩‍💻🏥

pubmed.ncbi.nlm.nih.gov/39228083/

Expanding the use of mathematical modeling in healthcare epidemiology and infection prevention and control - PubMed

During the coronavirus disease 2019 pandemic, mathematical modeling has been widely used to understand epidemiological burden, trends, and transmission dynamics, to facilitate policy decisions, and, t...

pubmed.ncbi.nlm.nih.gov

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Gwen Knight @gmknght.bsky.social · Jun 20

So great to see this 🦣 effort finally published!

Massive congratulations to Nichola Naylor (#AMR economist extraordinaire) and the rest of the team!

Do check out the amazing resources behind this estimates that can be used for other economic assessments for #AMR.

gh.bmj.com/content/10/6...

The global economic burden of antibiotic-resistant infections and the potential impact of bacterial vaccines: a modelling study

Introduction Antibiotic resistance (ABR) may increase hospital costs, utility loss and mortality risk per patient. Understanding these losses at national, regional and global scales is necessary for e...

gh.bmj.com

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Gwen Knight @gmknght.bsky.social · Jun 19

Thanks @yhgrad.bsky.social !

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Gwen Knight @gmknght.bsky.social · Jun 19

apologies yes thanks to @yhgrad.bsky.social its that one!

Gwen Knight @gmknght.bsky.social · Jun 19

Great combination of modelling and experimental data to better understand dynamic antibiotic exposure and #AMR

And "fitness seascapes" 🌊

doi.org/10.1126/scia...

doi.org

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Reposted by Gwen Knight

Kat Holt @katholt.bsky.social · Jun 10

Get your travel vaccines!
🌏💉
Typhoid vax is very effective BUT only lasts a few years so think about it EVERY time you travel.
Most cases are antibiotic resistant, so don’t think you can just take a pill 💊 if you get sick. More and more, resistant cases need hospitalisation & intravenous antibiotics

UK Health Security Agency @ukhsa.bsky.social · Jun 10

Our provisional data shows record numbers of typhoid and paratyphoid cases in England, Wales & Northern Ireland.

There were 702 cases in 2024, an 8% rise from 2023 (645 cases). This represents the highest number of cases recorded annually to date.

www.gov.uk/government/n...

Dr Philip Veal, Consultant in Public Health at UKHSA, said:
'We are seeing high levels of infections such as malaria and typhoid in returning travellers. It is important that travellers remain alert and plan ahead of going abroad – even if you’re visiting friends and relatives abroad or it’s somewhere you visit often.'

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Gwen Knight @gmknght.bsky.social · Jun 10

Very excited for this event on the 9th July!

It's part of our #AMR short course but open to everyone as it's online. Do join in and here what the amazing Prof Dame Sally Davies has to stay on the current status of global action on #AMR! @lshtmamrcentre.bsky.social

LSHTM AMR Centre @lshtmamrcentre.bsky.social · Jun 9

🎙️ Join Prof Dame Sally Davies, for an insightful seminar on global action against AMR.

In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy.

📅 9 July 2025
🕰️ 13:00 BST
📍 Online
🔗 bit.ly/4kVSVgP

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Reposted by Gwen Knight

LSHTM AMR Centre @lshtmamrcentre.bsky.social · Jun 9

🎙️ Join Prof Dame Sally Davies, for an insightful seminar on global action against AMR.

In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy.

📅 9 July 2025
🕰️ 13:00 BST
📍 Online
🔗 bit.ly/4kVSVgP

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Reposted by Gwen Knight

Kat Holt @katholt.bsky.social · May 22

Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight)
interpretamr.github.io/AMRrules

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Reposted by Gwen Knight

LSHTM AMR Centre @lshtmamrcentre.bsky.social · Jun 5

Researchers at @lshtm.bsky.social, led by @josebengoechea.bsky.social, will conduct a £2.2M study funded by UK MRC to investigate how Klebsiella pneumoniae silently colonises the gut before causing deadly infections. 🔬🦠

Read more 👉 bit.ly/4mNSreh

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Gwen Knight @gmknght.bsky.social · Jun 4

Great to see this coming out - phage have such potential but there are also many dynamics that we don't understand (and need to model!) and the specificity will always be a complexity....

UK Health Security Agency @ukhsa.bsky.social · Jun 4

The MHRA today released new guidance for #Phage therapy in the UK. This will provide direction for scientists and researchers working to make this treatment a reality for patients. 🔬 🧪

🔗 www.gov.uk/government/n...

Dr Colin Brown, deputy director at the UK Health Security Agency, responsible for AMR, said:

“Phage therapy truly has the potential to transform the way we treat bacterial infections, especially as resistance to antibiotics grows. At UKHSA, we’re developing new ways to help increase phage therapy use and research, including a bacteriophage collection where scientists can both access and deposit phages. In time, we hope solutions like phage therapy can become a first-line treatment option.”

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