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Reposted by Harsha Gouda

Ákos T Kovács @evolvedbiofilm.bsky.social · Aug 9

The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities

#CurrOpinMicrobiol by @harshagouda.bsky.social et al from @pieterdorrestein.bsky.social

www.sciencedirect.com/science/arti...

The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities

With the exception of molecules acquired through the lungs, skin absorption, or part of a medication regime, nearly all molecules in our bodies origin…

www.sciencedirect.com

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Harsha Gouda @harshagouda.bsky.social · Aug 8

We show how most dietary molecular features remain unknown, which are then further diversified by the gut microbiome, leading to more unkowns. Some cool experiments from @amcaraballor.bsky.social

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Harsha Gouda @harshagouda.bsky.social · Aug 8

The interactions between food, microbiome and host that modulate health can be complex. Here, we offer a perspective on how mass spectrometry can be leveraged to address some of these challenges to understand host and microbial metabolism of food. A step closer to personalized health and nutrition.

The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities

With the exception of molecules acquired through the lungs, skin absorption, or part of a medication regime, nearly all molecules in our bodies origin…

www.sciencedirect.com

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Harsha Gouda @harshagouda.bsky.social · May 30

Poster is made, printed and ready to go! Looking forward to my first mass-spec conference #ASMS2025 at Baltimore next week!

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Reposted by Harsha Gouda

Nature @nature.com · May 21

Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods

https://go.nature.com/4kybHea

How much ultra-processed food do you eat? Blood and urine record it

Samples could provide an objective measure of diets and help to unravel their contribution to disease.

go.nature.com

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Reposted by Harsha Gouda

Eric Topol @erictopol.bsky.social · Apr 24

New @science.org
Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective
www.science.org/doi/10.1126/...

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Reposted by Harsha Gouda

Trenton Dailey-Chwalibóg @trenton.phd · Apr 17

Should you return home after earning your PhD abroad? This Nature article explores the dilemmas faced by international researchers considering a move back to their home countries. A thought-provoking read for anyone navigating global academic careers.

www.nature.com/articles/d41...

Should I return to my home country after my PhD abroad?

A graduate student from southeast Asia, now based in a European country and missing her homeland, agonizes over her next career move.

www.nature.com

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Reposted by Harsha Gouda

David Broadhurst @davidbroadhurst.bsky.social · Apr 17

QC:MXP version 2.0 is now available to download for free from my GitHub page: www.qcmxp.org
Repeat-injection-based Quality Control, Batch Correction, Exploration & Data Cleaning. #Metabolomics #AnalyticalChemistry #Matlab

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Nature Portfolio @natureportfolio.nature.com · Apr 7

Individuals who were conceived in colder seasons are more likely to show higher brown adipose tissue activity, increased energy expenditure and a lower BMI, and lower fat accumulation around internal organs, suggests a study in Nature Metabolism. https://go.nature.com/4i3EYM0 🧪

This is figure 1, which shows season of fertilization predetermines the metabolic fate of brown adipose tissue in human adults.

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Reposted by Harsha Gouda

Julia M. Rohrer @dingdingpeng.the100.ci · Mar 20

New blog post! In which I explain the issue with mediation analysis and sketch out one way to deal with the underlying causal inference problem -- in just a bit over 1,000 words!

If you have never found the time to read up on this, now is your chance.

www.the100.ci/2025/03/20/r...

Reviewer notes: That’s a very nice mediation analysis you have there. It would be a shame if something happened to it.

Mediation analysis has gotten a lot of flak, including classic titles such as “Yes, but what’s the mechanism? (Don’t expect an easy answer)” (Bullock et al., 2010), “What mediation analysis can (not) ...

www.the100.ci

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Harsha Gouda @harshagouda.bsky.social · Mar 15

In the world of LLMs, why am I going to YouTube? To learn the basics!

Reposted by Harsha Gouda

Nature Metabolism @natmetabolism.nature.com · Mar 7

Discovery of metabolites prevails amid in-source fragmentation

Nature Metabolism, Published online: 28 February 2025; doi:10.1038/s42255-025-01239-4Discovery of metabolites prevails amid in-source fragmentation

bit.ly

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Nature @nature.com · Mar 4

Event organizers often overlook the visa-related difficulties that researchers in low- and middle-income countries face. This must change, says Kara Hanson

https://go.nature.com/3DioEc0

We moved a conference halfway around the globe to avoid visa discrimination

Event organizers often overlook the visa-related difficulties that researchers in low- and middle-income countries face. This must change.

go.nature.com

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Reposted by Harsha Gouda

BioMassSpec @realbiomassspec.bsky.social · Mar 1

Discovery of metabolites prevails amid in-source fragmentation #NatMetab www.nature.com/articles/s42...

Discovery of metabolites prevails amid in-source fragmentation - Nature Metabolism

Nature Metabolism - Discovery of metabolites prevails amid in-source fragmentation

www.nature.com

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Pieter Dorrestein @pieterdorrestein.bsky.social · Feb 28

Another fun paper that was started by a good and important question by Prajit - an undergrad in the lab - about imputation. We then teamed up with the Kelley lab as they are good at such benchmarking in data science. So fun to work woth them. pubs.acs.org/doi/10.1021/...

To Impute or Not To Impute in Untargeted Metabolomics─That is the Compositional Question

Untargeted metabolomics often produce large datasets with missing values. These missing values are derived from biological or technical factors and can undermine statistical analyses and lead to biase...

pubs.acs.org

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Reposted by Harsha Gouda

Cell Press @cellpress.bsky.social · Feb 27

The #InternationalSpaceStation is overly sterile; making it “dirtier” could improve astronaut health, microbiologists say. cell.com/cell/fulltex...

Learn more in @cp-cell.bsky.social
@pieterdorrestein.bsky.social, Rob Knight

The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns

With long-term space travel and extraterrestrial habitation becoming feasible, understanding how space environmental exposures, microbial communities, and molecular profiles differ from Earth is cruci...

cell.com

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Reposted by Harsha Gouda

Eric Topol @erictopol.bsky.social · Jan 13

A new resource rating >50,000 foods from 3 grocery stores
(Walmart, Target, and Whole Foods) for degree of processing and breakdown of ingredients
www.nature.com/articles/s43...
Website for consumers www.truefood.tech

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Pieter Dorrestein @pieterdorrestein.bsky.social · Jan 8

Such a wonderful SIMB workshop on @gnps2.bsky.social covering classical mol networking, FBMN, ion identity based mol networking, FBMN-STATS, gnps-dashboard, CMMC-kb, Modifinder, MicrobeMASST, MassQL, and limited ReDU - many were covered at a workshop for the first time. 1/4

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Pieter Dorrestein @pieterdorrestein.bsky.social · Jan 7

So fun at SIMB teaching the gnps ecosystem.

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Karsten Suhre @ksuhre.bsky.social · Dec 17

Metabolic changes of the blood metabolome after a date fruit challenge

doi.org/10.1016/j.jf...

7/12

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BioMassSpec @realbiomassspec.bsky.social · Dec 20

An accurate IDMS-based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean #JFoodSci ift.onlinelibrary.wiley.com/doi/10.1111/...

An accurate IDMS‐based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean

Abstract Phytohemagglutinin (PHA), a natural tetramer comprising PHA-E and PHA-L subunits that preferentially bind to red and white blood cells, respectively, constitutes a significant antinutrition...

ift.onlinelibrary.wiley.com

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Reposted by Harsha Gouda

ICTC13 @ictc13.bsky.social · Dec 19

Welcome to the wonderful #mzmine @mzmine.bsky.social team in Bluesky @bsky.app .
So nice to have you in #ICTC13 metabolomics workshop !
Check it out at www.ictc13.gr

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Cameron Martino @cameronmartino.bsky.social · Dec 19

New tensor factorization paper out today — a fun collaboration with Pixu Shi, Liat Shenhav, Rob Knight, & Anru_Zhang! 🎉 Check it out here: genomebiology.biomedcentral.com/articles/10....

TEMPTED: time-informed dimensionality reduction for longitudinal microbiome studies - Genome Biology

Longitudinal studies are crucial for understanding complex microbiome dynamics and their link to health. We introduce TEMPoral TEnsor Decomposition (TEMPTED), a time-informed dimensionality reduction ...

genomebiology.biomedcentral.com

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Harsha Gouda @harshagouda.bsky.social · Dec 19

HAHAHA 🤯

Nature @nature.com · Dec 19

All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is. 🧪

www.nature.com/articles/d41...

Why probability probably doesn’t exist (but it is useful to act like it does)

All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.

www.nature.com

Harsha Gouda @harshagouda.bsky.social · Dec 18

I’m starting to fall in love with math again. It was enzyme kinetics in grad school, now it’s testing different models on clinical data.