EMBL scientists found metabolism controls embryonic development tempo through signalling in a way separate from its established metabolic function.

More research related to this signalling could illuminate how it guides cell fate, developmental timing -- even disease.

www.embl.org/news/science...

Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!

Very happy to see this out, congratulations!!

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Excited to share our latest work out in @pnas.org! We show that the #SARSCoV2 nucleocapsid protein directly prevents DNA recognition of the immune sensor #cGAS by competing for DNA, which may delay early innate immune responses during infection. www.pnas.org/doi/epub/10.... #innateimmunity

We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social

We haven't tested these residues, but really interesting to see what would happen with Cys mutation!

The tricellular junction is a unique place where three or more cells contact. Here is our latest preprint showing the role of protein condensation in organizing molecular localization and function at tricellular junctions.
www.biorxiv.org/content/10.1...

This work was done at @mpi-cbg.de @hymanlab.bsky.social in Dresden, with lots of fantastic collaborations, especially with @savitski-lab.bsky.social. Thank you so much!

Some small molecules modulate protein condensation in cells, but how? Our latest work shows a possible mechanism of action of the small molecule lipoamide. This molecule prevents condensation of stress granules whose components are found as protein aggregates in ALS.
www.nature.com/articles/s41...