hiro-yoshi-jpn.bsky.social
Hiroyuki Yoshitomi
@hiro-yoshi-jpn.bsky.social
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Reposted by Hiroyuki Yoshitomi
natrevrheum.nature.com
Nature Reviews Rheumatology @natrevrheum.nature.com · Sep 5
New content online:
Two subsets of TPH cells with distinct functions in RA
Nature Reviews Rheumatology, Published online: 05 September 2025; doi:10.1038/s41584-025-01300-2Stem-like and effector-like peripheral helper T cells have distinct functions in rheumatoid arthritis.
bit.ly
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hiro-yoshi-jpn.bsky.social
Hiroyuki Yoshitomi @hiro-yoshi-jpn.bsky.social · Aug 16
📣Our new paper is out in Science Immunology.

Yuki Masuo revealed two distinct subsets of peripheral helper T (Tph) cells in #RheumatoidArthritis.
@chimomonga.bsky.social has nicely illustrated Tph-cell life.

doi.org/10.1126/scii...
@sciimmunology.bsky.social
@yuki-masuo.bsky.social
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hiro-yoshi-jpn.bsky.social
Hiroyuki Yoshitomi @hiro-yoshi-jpn.bsky.social · Aug 15
Another publication in Science Immunology. We revealed that stem-like peripheral helper T (Tph) cells self-renew, proliferate, and sustain the pathogenesis of #RheumatoidArthritis in the synovium.
doi.org/10.1126/scii...
@sciimmunology.bsky.social
‪@ashbi-kyotou.bsky.social‬
@yuki-masuo.bsky.social‬
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Reposted by Hiroyuki Yoshitomi
oriabe114.bsky.social
Saori Abe @oriabe114.bsky.social · Aug 1
www.science.org/doi/10.1126/...

“IGFL2 gene expression was specifically ⬆️ in #TPH cells in synovial tissue and fluid samples of patients with #RA. IGFL2 enhanced both TGF-β–induced production of CXCL13 by CD4 T cells and ⬆️ a shift in monocyte gene expression similar to pathogenic ones.”
#arthritis
Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor–like family member 2
IGFL2 is preferentially expressed by TPH cells and influences CD4+ T differentiation and macrophage activation in rheumatoid arthritis.
www.science.org
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Reposted by Hiroyuki Yoshitomi
immunoeditor.bsky.social
Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1
The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!

wwwscience.org/toc/sciimmun...
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Reposted by Hiroyuki Yoshitomi
sciencex.bsky.social
Science X / Phys.org @sciencex.bsky.social · Aug 1
A primate-specific cytokine, IGFL2, produced by helper T cells in rheumatoid arthritis joints, has been identified as a potential marker of disease activity and a target for new therapies. doi.org/g9vwcj
When immune commanders misfire: New insights into rheumatoid arthritis inflammation
Rheumatoid arthritis (RA) is a chronic autoimmune disease in which the immune system mistakenly attacks the lining of the joints (the synovium), causing pain, swelling, and progressive damage.
medicalxpress.com
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hiro-yoshi-jpn.bsky.social
Hiroyuki Yoshitomi @hiro-yoshi-jpn.bsky.social · Aug 2
Our study on immune responses in synovial tissue of patients with rheumatoid arthritis reveals the involvement of an evolutionary novel cytokine IGFL2 in the pathogenesis.

@sciimmunology.bsky.social
doi.org/10.1126/scii...
Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor–like family member 2
IGFL2 is preferentially expressed by TPH cells and influences CD4+ T differentiation and macrophage activation in rheumatoid arthritis.
doi.org
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Reposted by Hiroyuki Yoshitomi
focisimmunology.bsky.social
FOCIS - Federation of Clinical Immunology Societies @focisimmunology.bsky.social · Jul 1
FOCIS also wants to congratulate the 2025 recipient of the British Society for Immunology (BSI) Poster Prize Award - Yuki Masuo, MD 👏

#FOCIS2025
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