Unable to access, but would love to read this ! Any full text link 👀?

Big week for astrocyte research: 3 new Science papers link astrocytes to behavior. We're excited to add to the momentum with our new PNAS paper: a theory, grounded in biology, proposing astrocytes as key players in memory storage and recall. w/ JJ Slotine and @krotov.bsky.social
(1/6)

1/6 Why does the brain maintain such precise excitatory-inhibitory balance?
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social

(1/6) Excited to share a new preprint from our lab! Can large, deep nonlinear neural networks trained with indirect, low-dimensional error signals compete with full-fledged backpropagation? Tl;dr: Yes! arxiv.org/abs/2502.20580.

9/9
A huge thank you to my co-first author @SharonIsraely and @OriRajchert, @LeeElmaleh, @RanHarel, @FirasMawase,
@kadmonj.bsky.social , and @yifatprut.bsky.social ut.bsky.social for their invaluable contributions and support throughout this journey. 🙏

8/n
1️⃣ Our study provides new insights into how cerebellar signals constrain cortical preparatory activity, promoting generalization and adaptation.
2️⃣ We demonstrate that in the absence of cerebellar signals, cortical mechanisms are harnessed to restore adaptation, albeit with reduced efficiency.

7/n
⚫ The increased dimensionality under HFS was accompanied by a decrease in generalization performance, both at the neural and behavioral levels.

6/n
⚫ HFS led to higher dimensionality in neural activity, indicating a loss of structure in the neural representations, which is crucial for efficient motor learning and adaptation.

5/n
⚫ This compensation involved an angular shift in neural activity, suggesting a "re-aiming" strategy to handle the force field in the absence of cerebellar control.

4/n
⚫ Under high-frequency stimulation (HFS), we observed a bigger difference between FF and null field (NF) neural activity, indicating a compensatory mechanism in the motor cortex to adapt to the perturbation.

3/n
⚫ Under high-frequency stimulation (HFS), neural activity was altered in both a target-dependent and independent manner, showing that cerebellar signals contain task-related information.

2/n 🔍 Key Findings:

⚫ Cerebellar Block Impairs Adaptation: Blocking cerebellar outflow thanks to high-frequency stimulations (HFS) in the superior cerebellar peduncle significantly impairs force field (FF) adaptation, leading to increased motor noise and reduced error sensitivity.

🚨 Paper Alert! 🚨
1/n Thrilled to share our latest research, now published in Nature Communications! 🎉 This study dives deep into how the cerebellum shapes cortical preparatory activity during motor adaptation.
www.nature.com/articles/s41...
#neuroskyence #motorcontrol #cerebellum #motoradaptation

Created a starter pack of neuroscience in/from Paris.

Let me know if you want to be added (the 'from' can include those not in Paris anymore) or just tap in if you want to know what we're talking about!

Regardless, please re-tweet!

go.bsky.app/3Zs9w5w

For the Blueskyers interested in #NeuroAI 🧠🤖,
I created a starter pack! Please comment on this if you are not on the list and working in this field 🙂

go.bsky.app/CscFTAr

🧠🙋‍♂️