In this Perspective, Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.

Abstract. Understanding the complex interactions between microbes and their environment requires robust model systems such as synthetic communities (SynCom

Nature Reviews Bioengineering, Published online: 24 September 2025; doi:10.1038/s44222-025-00354-xMicrobial synthetic biology might greatly benefit from the application of non-model organisms, which have been evolutionarily optimized for the production of specific proteins and metabolites. This Review discusses the design and application of endogenous production in non-model organisms.

Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...

An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocol...

Podcast Episode · Night Science · 05/31/2022 · 40m

Wissenschaft/Forschung in Jena

imageimageEngineered transposon libraries coupled with temporal Tn-Seq data provide quantitative information on the fitness contribution of small genomic regions beyond coding sequences. A nuanced, non-static-non-binary model of gene essentiality ...

Ribonucleoproteins, nucleic acids and proteins are delivered into target cell types with nanosyringes.