Jacco
@jaccodk.bsky.social
Dutch guy living in Germany and working on cool optical engineering, electrokinetics and biophysics projects at [your name here]. Previously in Leiden as PhD in the lab of Michel Orrit.
Reposted by Jacco
Wow! This is so cool and way more fun than boring BioRender! Plus, developing fine motor skills through hand drawing and creativity without limitations in shapes or form! Try it out yourself here chat.figurelabs.ai/invitation/i...
December 23, 2025 at 8:26 AM
Wow! This is so cool and way more fun than boring BioRender! Plus, developing fine motor skills through hand drawing and creativity without limitations in shapes or form! Try it out yourself here chat.figurelabs.ai/invitation/i...
Reposted by Jacco
Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it.
PhD students: choose someone you like to talk to!
PhD students: choose someone you like to talk to!
December 19, 2025 at 4:35 PM
Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it.
PhD students: choose someone you like to talk to!
PhD students: choose someone you like to talk to!
Reposted by Jacco
Toegeven dat de kwaliteit achteruit gaat is iets waarvoor bestuurders allergisch zijn. Zelfs het online onderwijs tijdens corona werd destijds minstens zo goed gevonden als wat we in de collegezalen en laboratoria doen…
December 4, 2025 at 2:58 PM
Toegeven dat de kwaliteit achteruit gaat is iets waarvoor bestuurders allergisch zijn. Zelfs het online onderwijs tijdens corona werd destijds minstens zo goed gevonden als wat we in de collegezalen en laboratoria doen…
Reposted by Jacco
Monday blues no more with these online events by @comeincell.bsky.social (coordination: @dimovalab.bsky.social)
· 8 Dec, 2pm CET: “Drugging #Condensates & Drug Discovery” Dewpoint workshop
· 15 Dec 2pm CET: “Life in #Biotech” Dewpoint workshop
tinyurl.com/39rpaf84
#CellBiology #Biophysics
· 8 Dec, 2pm CET: “Drugging #Condensates & Drug Discovery” Dewpoint workshop
· 15 Dec 2pm CET: “Life in #Biotech” Dewpoint workshop
tinyurl.com/39rpaf84
#CellBiology #Biophysics
Events (Jul – Dec 2025) – ComeInCell
www.comeincell.org
December 1, 2025 at 4:39 PM
Monday blues no more with these online events by @comeincell.bsky.social (coordination: @dimovalab.bsky.social)
· 8 Dec, 2pm CET: “Drugging #Condensates & Drug Discovery” Dewpoint workshop
· 15 Dec 2pm CET: “Life in #Biotech” Dewpoint workshop
tinyurl.com/39rpaf84
#CellBiology #Biophysics
· 8 Dec, 2pm CET: “Drugging #Condensates & Drug Discovery” Dewpoint workshop
· 15 Dec 2pm CET: “Life in #Biotech” Dewpoint workshop
tinyurl.com/39rpaf84
#CellBiology #Biophysics
Goedkope Chinese producten overspoelen de wereld. Hoe moeten Europa en de VS daarop reageren? www.groene.nl/artikel/onev...
Goedkope Chinese producten overspoelen de wereld. Hoe moeten Europa en de VS daarop reageren?
De Chinese exportmachine is een wake-upcall voor economische beleidsmakers in de hele wereld. Importbarrières vormen niet het juiste antwoord. Wat dan wel?
www.groene.nl
December 1, 2025 at 2:16 PM
Goedkope Chinese producten overspoelen de wereld. Hoe moeten Europa en de VS daarop reageren? www.groene.nl/artikel/onev...
Reposted by Jacco
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma.
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
November 12, 2025 at 10:31 AM
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma.
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
Reposted by Jacco
The “canonical” story how Rosalind Franklin got wronged by Watson and Crick inadvertently makes her look far less scientifically competent than she was (“She did not realize the significance of her own data!”). This article offers a much more nuanced account of what happened.
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 2:55 PM
The “canonical” story how Rosalind Franklin got wronged by Watson and Crick inadvertently makes her look far less scientifically competent than she was (“She did not realize the significance of her own data!”). This article offers a much more nuanced account of what happened.
Reposted by Jacco
Coherence in optics is a really tricky topic for people. I feel like the language around it could be better/cleaner
November 4, 2025 at 5:36 AM
Coherence in optics is a really tricky topic for people. I feel like the language around it could be better/cleaner
Reposted by Jacco
Jetten 'wint' de verkiezingen en 'claimt' de zege na een 'spannende' 'race'. De 'exitpoll' was 'too close to call'. We zijn mentaal gekoloniseerd door de Amerikanen
October 31, 2025 at 1:01 PM
Jetten 'wint' de verkiezingen en 'claimt' de zege na een 'spannende' 'race'. De 'exitpoll' was 'too close to call'. We zijn mentaal gekoloniseerd door de Amerikanen
Reposted by Jacco
Tracking has always been at the ❤️ of the scientific method, from planetary motion to single particles.
Weiqing’s thesis intro on tracking was so beautiful we turned it into a perspective in JCP who then selected it as a #Scilight.
Take a look! 😊
www.aip.org/scilights/tr...
Weiqing’s thesis intro on tracking was so beautiful we turned it into a perspective in JCP who then selected it as a #Scilight.
Take a look! 😊
www.aip.org/scilights/tr...
Tracing fluorescence tracking’s past, present, and future
Artificial intelligence and parallel computing could refine studies of the movement of single molecules inside cells.
www.aip.org
October 30, 2025 at 11:19 PM
Tracking has always been at the ❤️ of the scientific method, from planetary motion to single particles.
Weiqing’s thesis intro on tracking was so beautiful we turned it into a perspective in JCP who then selected it as a #Scilight.
Take a look! 😊
www.aip.org/scilights/tr...
Weiqing’s thesis intro on tracking was so beautiful we turned it into a perspective in JCP who then selected it as a #Scilight.
Take a look! 😊
www.aip.org/scilights/tr...
Reposted by Jacco
New review on experimental datasets that can be used to benchmark protein force fields. And if that doesn’t tickle your fancy, the data can also be used to benchmark machine learning models for biomolecular structure and dynamics.
In the latest @livecomsjournal.bsky.social
perpetual review, Cavender et al overview NMR and crystallographic experimental datasets that can be used to benchmark protein force fields, including best practices for setup and analysis of simulations!:
livecomsjournal.org/index.php/li...
#compchem
perpetual review, Cavender et al overview NMR and crystallographic experimental datasets that can be used to benchmark protein force fields, including best practices for setup and analysis of simulations!:
livecomsjournal.org/index.php/li...
#compchem
October 28, 2025 at 3:51 PM
New review on experimental datasets that can be used to benchmark protein force fields. And if that doesn’t tickle your fancy, the data can also be used to benchmark machine learning models for biomolecular structure and dynamics.
Reposted by Jacco
Klimaatverandering komt op verkiezingsdag toch nog in het nieuws vanuit Jamaica.
Melissa staat in de top 10 sterkste orkanen ooit gemeten. Windkracht 13 (als dat bestond) in combinatie met tot wel 1 meter regen kan vanaf vannacht de westelijke helft van het eiland verwoesten, wordt gevreesd.
Melissa staat in de top 10 sterkste orkanen ooit gemeten. Windkracht 13 (als dat bestond) in combinatie met tot wel 1 meter regen kan vanaf vannacht de westelijke helft van het eiland verwoesten, wordt gevreesd.
October 28, 2025 at 12:08 PM
Klimaatverandering komt op verkiezingsdag toch nog in het nieuws vanuit Jamaica.
Melissa staat in de top 10 sterkste orkanen ooit gemeten. Windkracht 13 (als dat bestond) in combinatie met tot wel 1 meter regen kan vanaf vannacht de westelijke helft van het eiland verwoesten, wordt gevreesd.
Melissa staat in de top 10 sterkste orkanen ooit gemeten. Windkracht 13 (als dat bestond) in combinatie met tot wel 1 meter regen kan vanaf vannacht de westelijke helft van het eiland verwoesten, wordt gevreesd.
ls there a list of publishers who do this?
Everybody makes money out of academic authors except the authors...News.
Wiley is the latest academic publisher to reach a multi-million deal to allow access to its content to AI developers, with no opt out, let alone payment, for the authors who created that content.
Wiley is the latest academic publisher to reach a multi-million deal to allow access to its content to AI developers, with no opt out, let alone payment, for the authors who created that content.
Wiley set to earn $44m from AI rights deals, confirms “no opt-out" for authors
The US publisher is the latest to capitalise on deals to give tech firms access to its authors’ content to train their Large Language Models (LLMs).
www.thebookseller.com
October 7, 2025 at 8:01 AM
ls there a list of publishers who do this?
Reposted by Jacco
Dit zou een stemwijzer moeten zijn:
October 2, 2025 at 7:23 AM
Dit zou een stemwijzer moeten zijn:
Of een gat in de markt.
Dat lijkt me onverstandig.
Belastingdienst en Douane gaan - ondanks alle zorgen over Amerikaanse techbedrijven en wens Tweede Kamer om naar alternatieven te kijken - volledig over naar de cloud van Microsoft.
Link: www.tweedekamer.nl/kamerstukken...
Link: www.tweedekamer.nl/kamerstukken...
October 2, 2025 at 9:13 AM
Of een gat in de markt.
Reposted by Jacco
📢 Open Science Workshop on Detecting Errors and Misconduct in Science will be held in Nijmegen from October 20 to 23.
Full workshop program will be available soon.
🔗 Register here (limited spots are available!): lnkd.in/eRKekCkh
Full workshop program will be available soon.
🔗 Register here (limited spots are available!): lnkd.in/eRKekCkh
August 29, 2025 at 12:09 PM
📢 Open Science Workshop on Detecting Errors and Misconduct in Science will be held in Nijmegen from October 20 to 23.
Full workshop program will be available soon.
🔗 Register here (limited spots are available!): lnkd.in/eRKekCkh
Full workshop program will be available soon.
🔗 Register here (limited spots are available!): lnkd.in/eRKekCkh
Reposted by Jacco
Lipid droplets: Open questions and conceptual advances around a unique organelle. New review from Mike Henne (@hennelab.bsky.social), Emma Reynolds, and William: rupress.org/jcb/article/...
#Biochemistry #CellMetabolism #LipidDroplets
#Biochemistry #CellMetabolism #LipidDroplets
September 18, 2025 at 2:15 PM
Lipid droplets: Open questions and conceptual advances around a unique organelle. New review from Mike Henne (@hennelab.bsky.social), Emma Reynolds, and William: rupress.org/jcb/article/...
#Biochemistry #CellMetabolism #LipidDroplets
#Biochemistry #CellMetabolism #LipidDroplets
Reposted by Jacco
Check out this community comment in Nature Communications on biomolecular condensates! 🧪🔬 💧
The piece shows how condensates fundamentally change the study of biology, offering insights into cellular processes.
A great resource for anyone in the field, especially newcomers.
rdcu.be/eBqB3
The piece shows how condensates fundamentally change the study of biology, offering insights into cellular processes.
A great resource for anyone in the field, especially newcomers.
rdcu.be/eBqB3
Current practices in the study of biomolecular condensates: a community comment
Nature Communications - The realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry...
rdcu.be
September 3, 2025 at 6:56 AM
Check out this community comment in Nature Communications on biomolecular condensates! 🧪🔬 💧
The piece shows how condensates fundamentally change the study of biology, offering insights into cellular processes.
A great resource for anyone in the field, especially newcomers.
rdcu.be/eBqB3
The piece shows how condensates fundamentally change the study of biology, offering insights into cellular processes.
A great resource for anyone in the field, especially newcomers.
rdcu.be/eBqB3
Reposted by Jacco
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jacco
🚨 Molecular Biology of the Cell – Pasteur Course 🧬
This 4-week course explores the molecular mechanisms of cellular life — from vesicular trafficking and cell division to autophagy, host-pathogen interactions, and tumor invasion.
🕰️Application deadline: Sept 15,2025
👉 Apply: bit.ly/47celmj
This 4-week course explores the molecular mechanisms of cellular life — from vesicular trafficking and cell division to autophagy, host-pathogen interactions, and tumor invasion.
🕰️Application deadline: Sept 15,2025
👉 Apply: bit.ly/47celmj
August 27, 2025 at 3:47 PM
🚨 Molecular Biology of the Cell – Pasteur Course 🧬
This 4-week course explores the molecular mechanisms of cellular life — from vesicular trafficking and cell division to autophagy, host-pathogen interactions, and tumor invasion.
🕰️Application deadline: Sept 15,2025
👉 Apply: bit.ly/47celmj
This 4-week course explores the molecular mechanisms of cellular life — from vesicular trafficking and cell division to autophagy, host-pathogen interactions, and tumor invasion.
🕰️Application deadline: Sept 15,2025
👉 Apply: bit.ly/47celmj
Reposted by Jacco
Tools have long propelled discoveries:
"𝑁𝑜𝑡ℎ𝑖𝑛𝑔 𝑡𝑒𝑛𝑑𝑠 𝑠𝑜 𝑚𝑢𝑐ℎ 𝑡𝑜 𝑡ℎ𝑒 𝑎𝑑𝑣𝑎𝑛𝑐𝑒𝑚𝑒𝑛𝑡 𝑜𝑓 𝑘𝑛𝑜𝑤𝑙𝑒𝑑𝑔𝑒 𝑎𝑠 𝑡ℎ𝑒 𝑎𝑝𝑝𝑙𝑖𝑐𝑎𝑡𝑖𝑜𝑛 𝑜𝑓 𝑎 𝑛𝑒𝑤 𝑖𝑛𝑠𝑡𝑟𝑢𝑚𝑒𝑛𝑡"
Sir Humphry Davy
Elements of Chemical Philosophy (1812)
"𝑁𝑜𝑡ℎ𝑖𝑛𝑔 𝑡𝑒𝑛𝑑𝑠 𝑠𝑜 𝑚𝑢𝑐ℎ 𝑡𝑜 𝑡ℎ𝑒 𝑎𝑑𝑣𝑎𝑛𝑐𝑒𝑚𝑒𝑛𝑡 𝑜𝑓 𝑘𝑛𝑜𝑤𝑙𝑒𝑑𝑔𝑒 𝑎𝑠 𝑡ℎ𝑒 𝑎𝑝𝑝𝑙𝑖𝑐𝑎𝑡𝑖𝑜𝑛 𝑜𝑓 𝑎 𝑛𝑒𝑤 𝑖𝑛𝑠𝑡𝑟𝑢𝑚𝑒𝑛𝑡"
Sir Humphry Davy
Elements of Chemical Philosophy (1812)
August 26, 2025 at 10:27 AM
Tools have long propelled discoveries:
"𝑁𝑜𝑡ℎ𝑖𝑛𝑔 𝑡𝑒𝑛𝑑𝑠 𝑠𝑜 𝑚𝑢𝑐ℎ 𝑡𝑜 𝑡ℎ𝑒 𝑎𝑑𝑣𝑎𝑛𝑐𝑒𝑚𝑒𝑛𝑡 𝑜𝑓 𝑘𝑛𝑜𝑤𝑙𝑒𝑑𝑔𝑒 𝑎𝑠 𝑡ℎ𝑒 𝑎𝑝𝑝𝑙𝑖𝑐𝑎𝑡𝑖𝑜𝑛 𝑜𝑓 𝑎 𝑛𝑒𝑤 𝑖𝑛𝑠𝑡𝑟𝑢𝑚𝑒𝑛𝑡"
Sir Humphry Davy
Elements of Chemical Philosophy (1812)
"𝑁𝑜𝑡ℎ𝑖𝑛𝑔 𝑡𝑒𝑛𝑑𝑠 𝑠𝑜 𝑚𝑢𝑐ℎ 𝑡𝑜 𝑡ℎ𝑒 𝑎𝑑𝑣𝑎𝑛𝑐𝑒𝑚𝑒𝑛𝑡 𝑜𝑓 𝑘𝑛𝑜𝑤𝑙𝑒𝑑𝑔𝑒 𝑎𝑠 𝑡ℎ𝑒 𝑎𝑝𝑝𝑙𝑖𝑐𝑎𝑡𝑖𝑜𝑛 𝑜𝑓 𝑎 𝑛𝑒𝑤 𝑖𝑛𝑠𝑡𝑟𝑢𝑚𝑒𝑛𝑡"
Sir Humphry Davy
Elements of Chemical Philosophy (1812)
Quite special indeed
August 26, 2025 at 10:05 AM
Quite special indeed
Really nice example of why traps are useful:)
#smFRET-lovers! Imagine, you got nice burst data with freely diffusing molecules 🙌🔬
BUT
1) Immobilization does not work🧲🤬
2) Transitions are longer than diffusion time, but shorter than frametime of your TIRF⏱️
Solution: try ABEL-trap!💕
📜bioRxiv:
doi.org/10.1101/2025.07.22.666123
BUT
1) Immobilization does not work🧲🤬
2) Transitions are longer than diffusion time, but shorter than frametime of your TIRF⏱️
Solution: try ABEL-trap!💕
📜bioRxiv:
doi.org/10.1101/2025.07.22.666123
ABEL-FRET bridges the timescale gap in single-molecule measurements of the structural dynamics in the A2A adenosine receptor
The functional complexity of G protein-coupled receptors (GPCRs) arises from their structural dynamics, which span timescales from nanoseconds to minutes. Single-molecule Förster Resonance Energy Tran...
doi.org
August 17, 2025 at 5:14 AM
Really nice example of why traps are useful:)
Reposted by Jacco
My quote of the day
So keep fightin' for freedom and justice, beloveds, but don't you forget to have fun doin' it. Lord, let your laughter ring forth. Be outrageous, ridicule the fraidy-cats, rejoice in all the oddities that freedom can produce.
Molly Ivins
So keep fightin' for freedom and justice, beloveds, but don't you forget to have fun doin' it. Lord, let your laughter ring forth. Be outrageous, ridicule the fraidy-cats, rejoice in all the oddities that freedom can produce.
Molly Ivins
August 10, 2025 at 1:11 PM
My quote of the day
So keep fightin' for freedom and justice, beloveds, but don't you forget to have fun doin' it. Lord, let your laughter ring forth. Be outrageous, ridicule the fraidy-cats, rejoice in all the oddities that freedom can produce.
Molly Ivins
So keep fightin' for freedom and justice, beloveds, but don't you forget to have fun doin' it. Lord, let your laughter ring forth. Be outrageous, ridicule the fraidy-cats, rejoice in all the oddities that freedom can produce.
Molly Ivins
Reposted by Jacco
Can we learn motion models from post-processed tracks? 🧐
Not really 😢
Emission noise accounts for ~99% of the likelihood.
TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️
🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599
#Biophysics
Not really 😢
Emission noise accounts for ~99% of the likelihood.
TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️
🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599
#Biophysics
How Easy Is It to Learn Motion Models from Widefield Fluorescence Single Particle Tracks?
Motion models (i.e., transition probability densities) are often deduced from fluorescence widefield tracking experiments by analyzing single-particle trajectories post-processed from data. This analy...
arxiv.org
August 12, 2025 at 8:52 PM
Can we learn motion models from post-processed tracks? 🧐
Not really 😢
Emission noise accounts for ~99% of the likelihood.
TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️
🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599
#Biophysics
Not really 😢
Emission noise accounts for ~99% of the likelihood.
TLDR: What you think is anomalous diffusion… might just be noise. 🤷♂️🤷♂️🤷♂️🤷♂️
🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599
#Biophysics