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Reposted by Jean-Charles Lambert

Conceicao Bettencourt @saobettencourt.bsky.social · Aug 27

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social‬ as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease”

Join the network or DM for more info

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Jean-Charles Lambert @jclambert.bsky.social · Aug 24

In this preprint led by Devrim Kilinc and Pierre Dourlen, we observed that differential expression of BIN1 isoforms in the presynaptic part leads to differential synaptotoxicity. BIN1 isoforms could contribute to the synaptic loss observed in Alzheimer's disease.

www.biorxiv.org/content/10.1...

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity

Alzheimer’s disease (AD) is characterized by a strong genetic predisposition and by an early loss of synaptic connectivity that strongly correlates with cognitive deficit. Some genetic determinants co...

www.biorxiv.org

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Jean-Charles Lambert @jclambert.bsky.social · Aug 24

In this preprint, primarily conducted by Dolores Siedlecki, we established a neuron-microglia co-culture model within the synaptic chamber of a microfluidic device. This compartmented approach enables us to study synapse phagocytosis in close proximity to microglia.

www.biorxiv.org/content/10.1...

Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron–microglia co-culture model

Microglia play a critical role in synapse remodeling and neuroinflammation, both of which are dysregulated in Alzheimer′s disease (AD). However, most in vitro models rely on neonatal or immortalized m...

www.biorxiv.org

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Jean-Charles Lambert @jclambert.bsky.social · Aug 13

Perhaps 😉
I am sure that this controversy over APOE4 did not last long. However, it's true that he insisted, despite the odds being stacked against him, that it was TOMM40, not APOE, that was ultimately responsible for the APOE locus signal.

Jean-Charles Lambert @jclambert.bsky.social · Aug 13

Why do you say that the research community was sceptical? In fact, it was one of the least controversial genetic results obtained through a gene candidate approach. It was very quickly accepted by the research community because it was systematically replicated.

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Reposted by Jean-Charles Lambert

Reese Richardson @reeserichardson.bsky.social · Aug 4

Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community.

reeserichardson.blog/2025/08/04/a...

A do-or-die moment for the scientific enterprise

Reflecting on our paper “The entities enabling scientific fraud at scale are large, resilient, and growing rapidly”

reeserichardson.blog

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Jean-Charles Lambert @jclambert.bsky.social · Aug 2

In this new EADB preprint led by Ole Andreassen, we present an improved polygenic hazard score model for AD that demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models.

www.medrxiv.org/content/10.1...

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation

Objectives Polygenic hazard score (PHS) models can be used to predict the age-associated risk for complex diseases, including Alzheimer’s disease (AD). In this study, we present an improved PHS model ...

www.medrxiv.org

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Jean-Charles Lambert @jclambert.bsky.social · Jul 30

Happy cat on my belly

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Jean-Charles Lambert @jclambert.bsky.social · Jul 23

A new EADB paper published in Nature Communications and led by Kristel Van Steen, Cornelia Van Duijn and Valentina Escott-Price.
We report that machine learning methods have the potential to uncover novel loci that remain undetected by traditional GWAS in Alzheimer.
www.nature.com/articles/s41...

Machine learning in Alzheimer’s disease genetics - Nature Communications

Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional...

www.nature.com

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Jean-Charles Lambert @jclambert.bsky.social · Jul 19

Cette université est trop occupée à sauver la Science en accueillant des chercheurs américains

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Reposted by Jean-Charles Lambert

Mike Dailly ™ @mdf200.bsky.social · Jun 18

FromFB: 😂

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Jean-Charles Lambert @jclambert.bsky.social · Jun 18

5. The PGS/PRS associations mainly capture genetic information related to AD because they weakened as the diagnosis was broadened. The quality of the clinical diagnosis can interfere with the measurement of the association between the PGS/PRS and the AD risk in a given population.

Jean-Charles Lambert @jclambert.bsky.social · Jun 18

4. However, this is not the case when the PRS includes the APOE region. This indicates that the APOE region appears to contain additional multi-ancestry genetic variability.

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Jean-Charles Lambert @jclambert.bsky.social · Jun 18

3. In contrast to other multifactorial diseases, a cross-ancestry polygenic risk score (PRS) did not systematically outperform the simple PGS when the APOE locus was excluded. A high proportion of AD genetic risk could be already accounted for by the European-ancestry GWAS-defined loci.

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Jean-Charles Lambert @jclambert.bsky.social · Jun 18

2. This simple PGS appears to be enough to detect an AD genetic risk in most ancestry populations, suggesting that most of the various ancestry populations are likely to be affected by shared pathophysiological processes that are driven in part by genetic risk factors.

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Jean-Charles Lambert @jclambert.bsky.social · Jun 18

Our work produced several important findings:

1. The associations between a simple polygenic score (PGS) based on the European GWAS-defined loci and AD risk in European populations is slightly influenced by the APOE genotype, suggesting existence of independent genetic entities for sporadic AD

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Jean-Charles Lambert @jclambert.bsky.social · Jun 18

This work would not have been possible without this global and strongly collaborative effort (particularly Richard Sherva and Mark Logue of the Million Veteran Programme in the US, and Yoontae Kim and Jungsoo Gim of the GARD study in South Korea).

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Jean-Charles Lambert @jclambert.bsky.social · Jun 18

Finally out in Nature genetics !

A long journey to have this paper published. Led by my team, under the EADB umbrella (eadb.eu), the project involved numerous partners worldwide in assessing the genetic complexity of Alzheimer in populations of diverse ancestries.

www.nature.com/articles/s41...

Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations - Nature Genetics

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary ...

www.nature.com

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Reposted by Jean-Charles Lambert

Ian Kremer @leadcoalition.bsky.social · Jun 15

Trump’s cuts to more than 1700 #NIH grants get court hearing www.science.org/content/arti... by @sarareardon.bsky.social @science.org

#Alzheimers #dementia #neuroscience #science

Trump’s cuts to more than 1700 NIH grants get court hearing

District judge could declare terminations unlawful—or toss suit based on technicalities

www.science.org

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Reposted by Jean-Charles Lambert

Andy Moore @aaandmoore.bsky.social · Jun 11

This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.

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Reposted by Jean-Charles Lambert

Tal Nuriel, PhD @talnuriel.bsky.social · Jun 10

Announcing an official fundraising campaign to support my lab’s research on APOE4 and Alzheimer’s disease: joinus.cuimc.columbia.edu/participant/.... This campaign is itself an experiment of sorts. But mostly, it's an attempt to save my lab during an unprecedented time of turmoil in academia. 1/9

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Reposted by Jean-Charles Lambert

Ian Kremer @leadcoalition.bsky.social · Jun 6

Here is a direct link to the open access article ‪@amit-das.bsky.social‬ mentions. alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Tempting to say it feels like a miracle, but this progress always comes down to dedicated study participants, brilliant scientists, and reliably funded science.

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Reposted by Jean-Charles Lambert

Linda @linda2.bsky.social · May 24

I went in search of cygnets. Still not hatched so had to make do with a heron fishing instead. Look at those feet!

#UKWildlife #UKbirding #Birds #Photography #Nature #GreyHeron #photographersunited #PhotographersofBluesky #Sonyalpha

A grey heron stalking the waters for fish. Beak is low to the surface of the water. The heron has also sighted a fish and moves slowly not to disturb the water.

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Jean-Charles Lambert @jclambert.bsky.social · May 22

Currently visiting the Medieval Museum in Barcelona. This was painted in 1210…

Jean-Charles Lambert @jclambert.bsky.social · May 21

Je l’ai lu tout à l’heure.
Sans concession et loin des messages en creux adressés aux initiés dans ce gène de rapport. Et clairement indiqué l’activité néfaste de l’IHU durant le Covid

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