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Reposted by Emiliano Sotelo

Society for Molecular Biology and Evolution @official-smbe.bsky.social · 29d

📢 The Call for Symposia for SMBE2026 is now open. We warmly invite you to submit a symposium proposal and help shape the scientific content of our annual meeting.

🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3

More information: smbe2026.org/symposia

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Reposted by Emiliano Sotelo

Federico Sánchez Quinto @fsanchezquinto.bsky.social · Aug 29

Thrilled to share our study sequencing genetic data from tropical mammoths 🏝️🦣. First DNA recovered from Columbian mammoths southern than USA shorturl.at/xjIvy. Thanks to all collaborators, you were key to this success! See below a fantastic note covering the paper by the great @rpocisv.bsky.social 👇

Columbian mammoth mitogenomes from Mexico uncover the species’ complex evolutionary history

Paleogenomic studies suggest that Mammuthus columbi derives from an ancient hybridization between Mammuthus primigenius and Mammuthus trogontherii. While its habitat spanned from North to Central Amer...

shorturl.at

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Selene FeRNAndez @selfdz.bsky.social · Aug 1

Happy #RNA Day everyone!!! 🎉🎉🎉

#AUG1st #RNASky

a 3d rendering of a colorful dna molecule with a black background

ALT: a 3d rendering of a colorful dna molecule with a black background

media.tenor.com

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Reposted by Emiliano Sotelo

Thiago Carvalho @cyrilpedia.bsky.social · Jul 30

'Here, we show that transcription factor (TF) proteins, key players in gene regulation, can increase mutagenesis from replication errors by directly competing with the recognition of DNA mismatches by MutSα, the primary initiator of eukaryotic mismatch repair'
www.cell.com/cell/abstrac...

DNA mutagenesis driven by transcription factor competition with mismatch repair

Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

www.cell.com

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Reposted by Emiliano Sotelo

Samarendra Pani @samarendra-pani.bsky.social · Jul 24

[1/8] *New Open-Access Long Read Resource*. We sequenced 1,019 genomes from the 1000 Genomes Project sample cohort using @nanoporetech.com long-read sequencing (LRS) to median 17x coverage. Publication at go.nature.com/4ffPb8f.

@hhu.de @crg.eu @embl.org @impvienna.bsky.social

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Tobias Marschall @tobiasmar.bsky.social · Jul 23

Two papers in today's issue of @nature.com ‬: 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.

Complex genetic variation in nearly complete human genomes - Nature

Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

tinyurl.com

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Centre de Regulació Genòmica (CRG) @crg.eu · Jul 23

Researchers have significantly expanded the catalogue of known human genetic variation. Two studies in @nature.com resequenced data from the landmark 1000 Genomes Project with long-read tech, creating what may be the most complete overview of the human genome to date. www.nature.com/articles/s41...

Structural variation in 1,019 diverse humans based on long-read sequencing - Nature

Intermediate-coverage long-read sequencing in 1,019 diverse humans from the 1000 Genomes Project, representing 26 populations, enables the generation of comprehensive population-scale structural varia...

www.nature.com

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Reposted by Emiliano Sotelo

IMP @impvienna.bsky.social · Jul 23

Over 1,000 human genomes sequenced using long-read tech—Siegfried Schloissnig, computer scientist at the IMP, shares how it happened, key findings, and what it means for the future of genomics: www.imp.ac.at/news/article...

➡️Read the paper here: www.nature.com/articles/s41...

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Reposted by Emiliano Sotelo

Selene FeRNAndez @selfdz.bsky.social · Jul 22

Listening to former #RegRNALab member (now in the Moreno Lab) Jose Antonio Corona, presenting the #LatinCells project,seeking to characterise the genetic diversity of immune cells. Lots of extreme field work done for sampling indigenous populations across Latin America! 🌎

#SMBE2025

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Alejandra Medina-Rivera @alemedinarivera.bsky.social · Jul 2

Thanks @lecteroide.bsky.social for the opportunity to share the efforts developed in MexOmics

www.the-scientist.com/mexomics-map...

MexOMICs Maps the Genetic and Social Landscape of Disease in Mexico

By focusing on twins and patients with lupus and Parkinson’s disease, a Mexican consortium is generating critical data to understand health and disease in the country.

www.the-scientist.com

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Reposted by Emiliano Sotelo

Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Jun 16

🧬🌽 Happy Transposon Day! 🌽🧬

Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

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Virtual Fly Brain @virtualflybrain.bsky.social · Jun 12

VFB works closely with the FlyBase team and we rely on their hard work to provide many of our features. Due to the current funding situation at FlyBase (flybase.org), we encourage our users to donate and help maintain this essential resource.

FlyBase Homepage

FlyBase: a database for drosophila genetics and molecular biology

flybase.org

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Reposted by Emiliano Sotelo

Paulina Nuñez-Valencia @paulinanunezv.bsky.social · May 26

Check out our new preprint!
How can we get more out of existing protein/genome language models without retraining them?

Charlie Pugh @cwjpugh.bsky.social · May 26

New preprint in collaboration with @paulinanunezv.bsky.social supervised by @jonnyfrazer.bsky.social and Mafalda Dias – we propose a simple approach to improving zero-shot variant effect prediction in pre-existing protein and genome language models: 🧶 1/n

www.biorxiv.org/content/10.1...

From Likelihood to Fitness: Improving Variant Effect Prediction in Protein and Genome Language Models

Generative models trained on natural sequences are increasingly used to predict the effects of genetic variation, enabling progress in therapeutic design, disease risk prediction, and synthetic biolog...

www.biorxiv.org

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Mike Fainzilber @mfainzilber.bsky.social · May 16

A 🧵 to walk those interested through this paper...

Mike Fainzilber @mfainzilber.bsky.social · May 16

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening

www.cell.com/cell/fulltex...

Repeat-element RNAs integrate a neuronal growth circuit

SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.

www.cell.com

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Reposted by Emiliano Sotelo

Iana V. Kim @ianakim.bsky.social · May 7

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

www.nature.com

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Robert Castelo @robertclab.bsky.social · Apr 22

Participate in the Bioconductor community by sharing your work in a meeting designed to maximize interactivity and productivity at the seafront of Barcelona! 👩‍💻🏖️🧬 #EuroBiocC2025

Bioconductor @bioconductor.bsky.social · Apr 22

⏳ Time’s running out! Submit your abstract for #EuroBioC2025 by 24 April.
Join us this Sept in Barcelona to share your research, meet the #Bioconductor community & explore all things #Bioinformatics + #RStats.

👉 eurobioc2025.bioconductor.org/pages/submis...

Screenshot showing the EuroBioC2025 abstract submission deadline as April 24, 2025, and key conference dates for the Bioconductor community event in Barcelona, Spain.

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Bioconductor @bioconductor.bsky.social · Mar 31

🎉 Announcing the EuroBioC2025 Sticker Winner!

🏆 Chaima Hkimi’s design features the Sagrada Família, Park Güell colours, and a nod to Bioconductor in the text. Pick up the sticker at #EuroBioC2025!

#Bioconductor #Bioinformatics #RStats #StickerContest

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Reposted by Emiliano Sotelo

Cell Press @cellpress.bsky.social · Mar 31

"We should include eugenics in our undergraduate classes, reminding students that scientists must speak out when others lie about science and use it to further their political views," says professor @peiferlabunc.bsky.social.

www.cell.com/trends/genet...

@cp-trendsgenetics.bsky.social

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Reposted by Emiliano Sotelo

Daniel Bolnick @danielbolnick.bsky.social · Mar 27

Newly published in Genetics:
academic.oup.com/genetics/adv...
We ask what gene flow & introgression do to gene coexpression networks. The answer is: a lot.

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Reposted by Emiliano Sotelo

Clément Goubert @clementgoubert.bsky.social · Mar 24

Polymorphic transposable elements contribute to variation in recombination landscapes (drosohila 🪰) www.pnas.org/doi/full/10.... #TEsky

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Heng Li @lh3lh3.bsky.social · Mar 24

longcallD is a new variant caller for genomic long reads. It jointly calls phased small and structural variants. Single binary, one command line for the whole process. Comparable accuracy to mainstream callers. Great work by Yan Gao. github.com/yangao07/lon...

GitHub - yangao07/longcallD: A local-haplotagging-based small and structural variant caller

A local-haplotagging-based small and structural variant caller - yangao07/longcallD

github.com

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Dr. Tyler A. Elliott @transposableman.bsky.social · Mar 21

#TEsky The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition doi.org/10.7554/eLif...

The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.

doi.org

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manavellalab.bsky.social @manavellalab.bsky.social · Mar 21

Does the smell and flavor of strawberries depend on variations in gene-associated transposons? It seems so! Check out our new preprint! www.biorxiv.org/content/10.1...

Naturally occurring variation in gene-associated transposable elements impacts gene expression and phenotypic diversity in woodland strawberry

Transposable elements (TEs) constitute a major portion of plant genomes and play key roles in shaping genome architecture, regulating gene expression, and driving genome evolution. In this study, we g...

www.biorxiv.org

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Timothy Fuqua 🏳‍🌈 @timothyfuqua.bsky.social · Mar 5

Sending our manuscript back to review after getting some great constructive feedback!

Read here to see how random mutations in transposons can create new promoters. Any feedback is, of course, much appreciated.

www.biorxiv.org/content/10.1...

The latent cis-regulatory potential of mobile DNA

Transposable elements can alter gene regulation in their host genome, either when they integrate into a genome, or when they accrue mutations after integration. However, the extent to which transposon...

www.biorxiv.org

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Reposted by Emiliano Sotelo

Maya Voichek @mayavoichek.bsky.social · Mar 17

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

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