Lightnews — Scholar-powered news

jenna newman phd @jennanewman.bsky.social · 8h

“The conceptual advance here lies in moving beyond the paradigm of ‘overcoming the barrier’ toward ‘repairing the barrier.’…
In essence, this work illustrates that the BBB is not merely an obstacle to be bypassed but a dynamic &reparable interface whose dysfunction can be therapeutically reversed”🧪🛟

Prof Sam Illingworth @samillingworth.com · 9h

🧠 Alzheimer’s reversed in mice

A new study found that injecting nanoparticles can 'remind' the blood–brain barrier to function properly again, restoring normal brain activity in mice. Human trials could follow within years.

🔗 www.nature.com/articles/s41...

#SciComm #Alzheimers 🧪

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

www.nature.com

3 15

Reposted by jenna newman phd

Conrad Hackett @conradhackett.bsky.social · 9h

Has anything great happened in your life because of social media?

37 4 33

jenna newman phd @jennanewman.bsky.social · 8h

Reconnected with a buddy from my teens who’d always been sooo busy crushing on my best friend.
Married 10+ yrs now.
Good thing—as our daughter says—tastes change.

2

Reposted by jenna newman phd

Eric Michael Garcia @ericmgarcia.bsky.social · 10h

What are some policies that nobody talks about or that flew under the radar but were low-key kind of successful?

16 4 20

jenna newman phd @jennanewman.bsky.social · 9h

Free pre-k3 & pre-k4 in dc public schools

2

jenna newman phd @jennanewman.bsky.social · 10h

Gulf War illness impacts “up to 1/3 of the 700k troops deployed during Operation Desert Shield & Operation Desert Storm more than 30 yrs ago….
studies link Gulf War illness to chemical exposures that impair the body’s mitochondria—‘the energy powerhouses of cells’—& alter the brain &immune system”🧪🛟

Kelly Kennedy @kellyskennedy.bsky.social · 1d

Brilliant. I had friends who were sick almost immediatel—hardcore, annoyingly gung-ho friends who were just debilitated. www.stripes.com/veterans/202...

‘Long-overdue validation’: CDC formally recognizes Gulf War illness

The symptoms affect up to a third of the 700,000 troops deployed during Operation Desert Shield and Operation Desert Storm more than 30 years ago.

www.stripes.com

1 3 15

Reposted by jenna newman phd

John Cluverius @johncluverius.bsky.social · 12h

oh my god just hook it to my veins.

jamelle @jamellebouie.net · 12h

did i eat this entire plate of ethiopian? yes, i did.

1 9

jenna newman phd @jennanewman.bsky.social · 11h

“Mr. Whitney, 76, is a scientific unicorn….He has a rare genetic mutation that essentially guaranteed he would develop Alzheimer’s disease in his late 40s or early 50s &would likely die w/in a decade…
Scientists are searching for the recipe for his biological secret sauce.”🧪🛟 @pambelluck.bsky.social

Kathleen Bachynski @bachynski.bsky.social · 11h

“His mother & nine of her 13 siblings developed Alzheimer’s & died in the prime of their lives. So did his oldest brother, and other relatives going back generations. It is the largest family in the US known to have an Alzheimer’s-causing mutation…Something has shielded him from his genetic destiny”

He Was Expected to Get Alzheimer’s 25 Years Ago. Why Hasn’t He?

www.nytimes.com

1 4 34

Reposted by jenna newman phd

Ariel Edwards-Levy @aedwardslevy.bsky.social · 12h

once again asking all surveys to include an "anything else you would like to tell us" at the end because I guarantee you I will have helpful* thoughts on your questionnaire design

*YMMV, but then again YMM be wrong, particularly if all your fave questions have "never heard of" but not "no opinion"

7 4 36

jenna newman phd @jennanewman.bsky.social · 11h

SES, GS, PMF

Jess Calarco @jessicacalarco.com · 1d

quantitative methods, qualitative methods, mixed methods

Photo of a Kansas City Chiefs press conference with Andy Reid, Travis Kelce, and Patrick Mahomes. Reid is wearing a gray suit and red tie with a lapel pin. Kelce is wearing a camp-style short-sleeved shirt with a bird print, along with a suede cap, and Mahomes is wearing a white collared shirt, a pink checkered double-breasted vest, and a pale pink tie.

1 4

Reposted by jenna newman phd

Kelli Russell Agodon @kelliagodon.bsky.social · 20h

"her memory is a cloud she can't hold..."

Lots of feels with this poem for my mum. Sent with love for anyone with a parent or loved one with Alzheimer's/dementia. It's a journey.

(And thank you @poetsorg.bsky.social and Rick Barot for sharing this one. It means a lot.)

6 18 60

Reposted by jenna newman phd

derek guy @dieworkwear.bsky.social · 12h

glad to be born at a time when i got to see what life was like before the internet and will be dead before AI completely destroys humanity

150 780 6.8K

Reposted by jenna newman phd

David Ho @davidho.bsky.social · 13h

Current mood

A cartoon depicts a man and a woman walking side by side on a street. The woman wears a stylish dress and holds a purse, while the man is in a suit. The caption reads, "My desire to be well-informed is currently at odds with my desire to remain sane.”

3 93 440

Reposted by jenna newman phd

Helen Rosner @hels.bsky.social · 22h

I love this profile — the idea of both girlhood and womanhood as roles to be inhabited, the self both outside and inside these categories

Emily Nussbaum @emilynussbaum.bsky.social · 22h

My profile of the delightful Keri Russell, the darkly funny, surprisingly introverted former New Mickey Mouse Club member who—even after Felicity, The Americans and The Diplomat!—has never fully embraced the idea of herself as an actress: www.newyorker.com/magazine/202...

Keri Russell’s Emotional Transparency Has Anchored Three Decades of TV

But, offscreen, she’s not even sure that she wants to be an actress.

www.newyorker.com

4 67

jenna newman phd @jennanewman.bsky.social · 22h

“‘It was a level of effect that was beyond even our wildest expectations’…
Over 6 months, 34 kids in the permethrin-wrap group tested positive for malaria, compared w/ 94 in the water-soaked wrap grp, a reduction of~65%…suggest[ing] mosquitoes are biting more often than thought during the daytime”🛟🧪

NPR @npr.org · 23h

Inspired by a military strategy to ward off disease-carrying mosquitoes, researchers see if the technique will help cut malaria infections in little ones. n.pr/3IwwWQc

Babies take a lesson from soldiers in the war against malaria

Inspired by a military strategy to ward off disease-carrying mosquitoes, researchers see if the technique will help cut malaria infections in little ones.

n.pr

6

Reposted by jenna newman phd

The Whimsical Muse @whimsicalmuse.bsky.social · 23h

At the end of the day, don’t we all just want to read books in a cottage during a pouring rain in front of a crackling fire whilst enjoying a plate of emotional support cinnamon rolls?

20 49 470

Reposted by jenna newman phd

Hannah Grieco @writesloud.bsky.social · 1d

Really good story at NYer this week. I'm such a fan of David Wright Faladé, and this story is so beautiful and understated and real.

www.newyorker.com/magazine/202...

“Amarillo Boulevard,” by David Wright Faladé

Jean stepped out of the car as Nia approached—lean and arrogant, a cigarette pinched between her lips. Then her swagger slipped, her expression unsettled.

www.newyorker.com

1 3

Reposted by jenna newman phd

Jess Calarco @jessicacalarco.com · 1d

quantitative methods, qualitative methods, mixed methods

14 84 400

Reposted by jenna newman phd

heather bussing @heatherbussing.bsky.social · 23h

breathe

in plane view

Sunbeams shining through clouds and illuminating bright green fields and a town below.

2 8

Reposted by jenna newman phd

KJ Charles @kjcharleswriter.com · 1d

/adds to lexicon/

Esther Schindler @estherschindler.bsky.social · 1d

I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.

1 130 450

Reposted by jenna newman phd

Esther Schindler @estherschindler.bsky.social · 1d

I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.

25 2.1K 6.3K

jenna newman phd @jennanewman.bsky.social · 1d

Research findings illuminate “a promising pathway for developing effective clinical interventions…& ultimately enhancing patient outcomes.
‘Our study demonstrated remarkable efficacy in…restoring healthy function in the blood–brain barrier &leading to a striking reversal of Alzheimer’s pathology’.”🧪

jenna newman phd @jennanewman.bsky.social · 1d

“The team demonstrated that targeting a specific mechanism enables undesirable ‘waste proteins’ produced in the brain to pass thru [the BBB] barrier &be eliminated in the blood flow.

In Alzheimer’s disease, [accumulation of] the main ‘waste’ protein…impairs the normal functioning of the neurons.”🧪

Ian Kremer @leadcoalition.bsky.social · 1d

Scientists reverse Alzheimer’s in mice using nanoparticles ibecbarcelona.eu/consiguen-re... via @ibecbarcelona.eu

#Alzheimers #dementia #bioengineering #science

3 8

jenna newman phd @jennanewman.bsky.social · 1d

“The team demonstrated that targeting a specific mechanism enables undesirable ‘waste proteins’ produced in the brain to pass thru [the BBB] barrier &be eliminated in the blood flow.

In Alzheimer’s disease, [accumulation of] the main ‘waste’ protein…impairs the normal functioning of the neurons.”🧪

Ian Kremer @leadcoalition.bsky.social · 1d

Scientists reverse Alzheimer’s in mice using nanoparticles ibecbarcelona.eu/consiguen-re... via @ibecbarcelona.eu

#Alzheimers #dementia #bioengineering #science

Scientists reverse Alzheimer’s in mice using nanoparticles - Institute for Bioengineering of Catalonia

An international team co-led by the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital Sichuan University (WCHSU) was able to reverse Alzheimer’s in mice after only 3 injecti...

ibecbarcelona.eu

8 19

Reposted by jenna newman phd

Faine Greenwood @faineg.bsky.social · 1d

I like eating dry hot cocoa mix out of the bag, with marshmallows, like a horribly Pixie Stick. Gives you the weirdest mouth feel afterwards. Fuck I’ve never admitted this one to anyone

78 6 810

jenna newman phd @jennanewman.bsky.social · 1d

*clumpy* drivethru icecream floats on roadtrips
1. surreptitiously take a kid’s McDonalds milkshake (if caught: “just checking to make sure it’s not poisonous!”)
2. pour—a good long pour—into cup of Coke; crucial to have much ice.
3. Standby. With napkins. volcanic foaming eventually self-resolves

6