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Julien Park @jhpark.bsky.social · 24d

This was associated with mitochondrial dysfunction and structural changes. Substitution of ascorbic acid led to decreased H2O2 levels and improved cell survival. This offers a potential therapeutic approach for this #raredisease

Julien Park @jhpark.bsky.social · 24d

HO-1 deficiency is a devastating disorder of redox metabolism with few therapeutic options. In two independent models, we observed increased hydrogen peroxide and decreased ascorbic acid levels despite upregulation of SVCT2, a key ascorbic acid transporter.

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Julien Park @jhpark.bsky.social · 24d

‼️New Publication‼️
So glad the first manuscript from my lab is finally out in @asbmbjournals.bsky.social
We studied redox changes in HO-1 deficiency and found substantial ascorbic acid depletion as a key pathogenetic feature.

tinyurl.com/3ujw5ryt

Ascorbate mitigates oxidative stress and hemin cytotoxicity in heme oxygenase-1 deficiency

Heme oxygenase-1 (HO-1) deficiency manifests with severe metabolic abnormalities, yet the underlying mechanisms remain incompletely understood. We investigated metabolic adaptations in HO-1 deficient ...

tinyurl.com

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Reposted by Julien Park

Jeroen Guikema @jeroenguikema.bsky.social · Dec 11

This is pretty wild! Efficient non-viral genome editing of immune cells using circular single-stranded DNA. #science #hemesky 🩸🔬 www.nature.com/articles/s41...

Efficient non-viral immune cell engineering using circular single-stranded DNA-mediated genomic integration - Nature Biotechnology

CAR-T and NK cells engineered using a non-viral circular single-stranded DNA system show effective anti-tumor function.

www.nature.com

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Julien Park @jhpark.bsky.social · Dec 1

Umeå is such a lovely place!

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Julien Park @jhpark.bsky.social · Nov 25

Finally said goodbye to #twitter The sky‘s looking blue and I‘m looking forward to our conversations here! #science #medicine

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Reposted by Julien Park

Joseph Flynn, MD @jostflynnmd.bsky.social · Nov 13

Inborn errors of metabolism in neonates and pediatrics on varying dialysis modalities: a systematic review and meta-analysis
link.springer.com/article/10.1...

Inborn errors of metabolism in neonates and pediatrics on varying dialysis modalities: a systematic review and meta-analysis - Pediatric Nephrology

Background Some inborn errors of metabolism (IEMs) resulting in aberrations to blood leucine and ammonia levels are commonly treated with kidney replacement therapy (KRT). Children with IEMs require p...

link.springer.com

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Julien Park @jhpark.bsky.social · Nov 17

Are you looking for a PhD position in #rarediseases ? Are you interested in #redox metabolism? Come and join us in Münster! jobs-sf.ukmuenster.de/job/Universi...

PhD Student (gn*)

jobs-sf.ukmuenster.de

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Julien Park @jhpark.bsky.social · Nov 13

Happy to say that we‘re hiring! Come work with us as a PhD student working on inborn errors of redox metabolism #IEM #IMD. We‘re a young team focusing on this underserved group of #rarediseases.
If you need more info, please reach out to me! jobs-sf.ukmuenster.de/job/Universi...

Doktorand (gn*)

jobs-sf.ukmuenster.de

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Julien Park @jhpark.bsky.social · Nov 12

A great honor to have been part of this team effort!

Journal of Inherited Metabolic Disease @jimd-editors.bsky.social · Nov 12

Mito disease management is largely symptomatic. A subset respond well to specific vitamins or cofactors, but evidence of benefit in most is poor although prescribing is common.

A survey of global vitamin & cofactor prescribing practices in PMD.

👉 doi.org/10.1002/jimd...

@jhpark.bsky.social

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Julien Park @jhpark.bsky.social · Nov 19

Very happy to do so! And great to connect on here

Reposted by Julien Park

kinderdok @kinderdok.bsky.social · Oct 18

Hey, @kbv.de:
Aus eins mach zwei: Bei Intensivpflege für häusliche mobile Krankenpflege gab es bisher Formular 12,
jetzt dürfen wir Formulare 62b und 62c ausfüllen,
ist ja nur mal schnell doppelte Arbeit und doppeltes Fehlerpotential.

Bürokratie-Abbau für den A…!
#PraxisAlltag

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Julien Park @jhpark.bsky.social · Oct 18

Hi Bluesky! Looking to connect with anyone interested in #metabolism and #IEM and #pedsneuro. Trying to finalize my exit from the other app!

Reposted by Julien Park

DrGlitterbear @drglitterbear.bsky.social · Oct 17

Who wants to be my colleague?

My department has an Assist Prof GI physiologist or microbiome position: jobs.rutgers.edu/postings/212...

Please share and repost!

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Reposted by Julien Park

Hao Yin @haoyin.bsky.social · Oct 8

Developmental & regenerative vascularization #zebrafish spinal cord
#SciArt

Contusion #SpinalCordInjury
90 dpi

Less dense More linear vessels
Barrier restored

#Pericyte proliferate in reparative #Angiogenesis
Ana Ribeiro, Leonor Saúde labs Open Biol 2023
royalsocietypublishing.org/doi/10.1098/...

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Reposted by Julien Park

𝗖👽𝗥𝗟🎃WEEN @carl.bsky.social · Sep 10

Body goals

I'm actually not sure how to effectively describe this. It's a model of inside a human but really distorted so the human looks like a slug? I don't know I'm not a doctor!

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Julien Park @jhpark.bsky.social · Aug 29

Thanks a lot! Will keep these in mind.

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Julien Park @jhpark.bsky.social · Aug 29

Starting off #SSIEM2023 w/ a session re/ nutrition and dietetics!

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Julien Park @jhpark.bsky.social · Aug 27

On my way to Jerusalem for this year’s #SSIEM meeting. Looking forward to talks, meetings, and more all related to #metabolic disease!

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Reposted by Julien Park

Marc Veldhoen @marcveld.bsky.social · Aug 27

Column: Scientists used to love Twitter.

Thanks to Elon Musk, they’re giving up on it "found Twitter to be “a useful and at times almost essential tool for timely and important exchange of information.”

Column: Scientists used to love Twitter. Thanks to Elon Musk, they're giving up on it

Scientists came to see Twitter as an indispensable tool for communicating with each other and the public. As X, it's turned into a source of scientific misinformation and lies.

www.latimes.com

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Reposted by Julien Park

Benjamin Brigant, PhD @crisprandbeyond.bsky.social · Aug 27

Sunday Funday!

🧪Using this meme to Introduce a new feed "Skyentific Jokes" for all scientists with a sense of humor.🌌 Your new go-to spot for the most cosmic science jokes

bsky.app/profile/did:...
Tags: #ScienceJokes #lab&fun

Feedback welcome to refine the feeds & tags.

#AcademicSky #PhDSky

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Julien Park @jhpark.bsky.social · Aug 27

Während meiner Zeit in Schweden im Winter Vitamin D. Ansonsten nichts.

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Julien Park @jhpark.bsky.social · Aug 26

@danirabaiotti.bsky.social I‘d love to join What‘s Science - could dou add me, please?

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Julien Park @jhpark.bsky.social · Aug 26

Hi Bluesky, I‘m Julien, a physician-scientist trying to work out the influence of redox dysbalance in inborn errors of metabolism. Hoping to connect w/ clinicians & basic scientists alike! Really hoping to see an even better science twitter here.

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