Neglected tropical diseases are ancient maladies that continue to disproportionately affect more than one billion of the world’s poorest people. In 2021, as part of its strategy to achieve the Sustainable Development Goals, the World Health Organization renewed its commitment to end their neglect by 2030. On World Neglected Tropical Diseases Day 2026, we discuss the need for an integrated approach to overcome the “last mile” barriers to achieving their eradication and elimination.

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

Cryo-electron microscopy structures of the bile acid transporter OSTα–OSTβ, which has a key role in bile acid homeostasis, provide insight into its distinct architecture and mechanism of substrate translocation.

Mycobacterium tuberculosis produces linoleic acid, which is released from macrophages during infection and upregulates regulatory T cell activity, to suppress macrophage control of intracellular bacte...

Nature - Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

This study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt...

A leading HIV vaccine strategy requires a priming immunogen to induce broadly neutralizing antibody (bnAb) precursors, followed by a series of heterologous boosters to elicit somatic hypermutation (SH...

A diet rich in diverse carbohydrates outperforms faecal transplants in mice at restoring microbial diversity, which has been linked to a range of health conditions.

Another man also regained some movement, but two others experienced minimal improvement.

Nature Reviews Microbiology, Published online: 24 March 2025; doi:10.1038/s41579-025-01173-yIn this study, Thakur et al. demonstrate the interconnected role of diet, host genetics and oncogenic microorganisms in colon carcinogenesis.

It is increasingly clear that microplastic pollution can be detrimental to human, animal and environmental health. More research is needed to determine if and how our microbial partners are also negat...

BMC Gastroenterology

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