Lightnews — Scholar-powered news

Jongmin Kim @jongminkmg.bsky.social · 21d

Exciting work on orphan genes in fertilization and evolution!

Geoff Findlay @geofffindlay.bsky.social · 22d

Excited to share that our new NSF RUI grant was funded! 🎉🪰 We'll be looking into Drosophila fertilization proteins and studying how orphan genes function in non-model fly species. We're hiring for a 3-year lab manager/staff scientist position: app.jobvite.com/j/?cj=oGzWxf... Shares/RTs appreciated!

College of the Holy Cross is looking for Lab Manager / Staff Scientist.

College of the Holy Cross is looking for Lab Manager / Staff Scientist. Learn more or Jobvite a friend.

app.jobvite.com

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Jongmin Kim @jongminkmg.bsky.social · 25d

Congrats, Anna! 🎉

Jongmin Kim @jongminkmg.bsky.social · Aug 31

Avidity.

In plants, PRC2 accessory VEL proteins polymerize much like PRC1 subunits in animals, reinforcing silencing. Multimerization - overcoming weak affinity through 'avidity' - seems to be an important conserved principle in chromatin regulation.

pubmed.ncbi.nlm.nih.gov/40858112/

VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing - PubMed

Multivalent protein-chromatin interactions facilitated by higher-order protein assemblies are emerging as a crucial theme in eukaryotic gene regulation. However, understanding the underlying mechanism...

pubmed.ncbi.nlm.nih.gov

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Jongmin Kim @jongminkmg.bsky.social · Aug 25

Donated. FlyBase is a truly essential resource!

FlyBase @flybase.bsky.social · Aug 15

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

FlyBase:Contribute to FlyBase - FlyBase Wiki

wiki.flybase.org

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Jongmin Kim @jongminkmg.bsky.social · Aug 22

Congrats, Ellen! This is so exciting 😊

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Jongmin Kim @jongminkmg.bsky.social · Jul 16

Thanks for the explanation, Li. It is a good reminder to me not to assume all Aly-class genes regulate the same targets. Looking forward to learn what you find about their roles in de novo genes. Congrats again!

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Jongmin Kim @jongminkmg.bsky.social · Jul 16

Exciting work!

Many Achi/Vis targets seem not expressed in the tMAC (aly) mutant (as you discussed). Curious if Aly motif (AGYWGGC) sits upstream of Achi/Vis motif in de novo genes. If so, it is interesting how selection resulted in a simple, but still reasonably complex regulatory syntax.

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Jongmin Kim @jongminkmg.bsky.social · Jul 15

A brief mountain break.

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Jongmin Kim @jongminkmg.bsky.social · Jun 18

Reducing H1 levels (by CRAMP1 KD) derepresses PRC2 target genes without reducing H3K27me3. It was interesting:

1) once again, H3K27me3 mark alone seems not sufficient for gene repression,
2) how is H1 deposited at Polycomb target sites?

Congrats, Iva!

EPIGENETIC HULK @epigenetichulk.bsky.social · Jun 16

CRAMP! SO ANNOYING BUT NEEDS TO KEEP LINKER HISTONES! EPIGENETIC HULK DO WITHOUT! UNLESS IT THE BAND SO THEN COOL! www.cell.com/molecular-ce...

CRAMP1 drives linker histone expression to enable Polycomb repression

Challenging the prevailing view that H1 linker histones represent a general feature of repressed chromatin, Matthews et al. show a specific requirement for H1 in epigenetic repression by PRC2. Ablatio...

www.cell.com

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Jongmin Kim @jongminkmg.bsky.social · Jun 13

Beautifully written, Susanna! 😊

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Jongmin Kim @jongminkmg.bsky.social · Jun 13

True: my ESI MIRA, submitted last February, was withdrawn three weeks before the study section because of a support letter. No sub-award, no expected co-authorship, just a letter. So be careful - their definition of 'collaboration' is very broad.

NIH Vigils @nihvigils.bsky.social · Jun 12

NIH APPLICANTS:

Your application will be WITHDRAWN BEFORE REVIEW if you have an international collaboration and do not include a Foreign Justification.

Normally this could be provided after review as JIT but NOT ANYMORE.

You have been warned.

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Jongmin Kim @jongminkmg.bsky.social · Jun 11

Congrats, Susanna!! 🎉

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Jongmin Kim @jongminkmg.bsky.social · Jun 8

Congrats on your exciting work!

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Jongmin Kim @jongminkmg.bsky.social · Jun 6

I find unstructured regions in proteins enigmatic and very interesting.

dairegannon.bsky.social @dairegannon.bsky.social · Jun 6

Great to see @jongminkmg.bsky.social’s preview of our work in @cp-molcell.bsky.social today!
www.cell.com/molecular-ce...

Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma

In this issue, Lagan et al.1 apply genome-wide and tiling-scan CRISPR screens to uncover a key role for CBX4 and its central region in promoting the growth of diffuse midline glioma cells bearing the ...

www.cell.com

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Jongmin Kim @jongminkmg.bsky.social · Jun 6

Congrats on your exciting work!

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Jongmin Kim @jongminkmg.bsky.social · May 17

Great news! Congratulations!! 🎉

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Jongmin Kim @jongminkmg.bsky.social · Mar 13

" The common genetic marker Stubble influences Fab2L transgene expression" - balancer and marker mutations are not always inert.

Fitz-James Lab @fitz-james-lab.bsky.social · Mar 12

1/10 Excited to share our recent work with @psarkies.bsky.social out in Open Biology today.

We follow up on a case of Drosophila epigenetic inheritance and find no evidence of sRNA involvement. Plus a surprising result of interest to Drosophilists!
royalsocietypublishing.org/doi/10.1098/...

Polycomb-mediated transgenerational epigenetic inheritance of Drosophila eye colour is independent of small RNAs | Open Biology

Transgenerational epigenetic inheritance (TEI) describes the process whereby distinct epigenetic states are transmitted between generations, resulting in heritable gene expression and phenotypic diffe...

royalsocietypublishing.org

Jongmin Kim @jongminkmg.bsky.social · Feb 11

Thank you. I emailed his office.

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Reposted by Jongmin Kim

Patrick Murphy @pjmurphy249.bsky.social · Jan 28

Today’s the day! I’m happy to announce that the Murphy Lab will be moving to Cornell this July! The lab will be in Biotech and I’ll be joining the Department of Molecular Biology and Genetics. There will be lots of recruiting soon, including students and postdocs. Please RT. 🙏 TY.

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Jongmin Kim @jongminkmg.bsky.social · Jan 22

Great opportunity for postbacs to do exciting research and gain experience before graduate school!

Amanda Amodeo @aaamodeo.bsky.social · Jan 21

My lab is looking to hire a research technician!

Techs in my group run their own projects and participate fully in the scientific discussions in the lab (this is not a wash glassware, make media position). Ideal for someone looking to get a bit more research experience before applying for a PhD.

Jongmin Kim @jongminkmg.bsky.social · Jan 21

The sun has been rather scarce in Ithaca lately. Nice to see some sunrise this morning.

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Jongmin Kim @jongminkmg.bsky.social · Jan 21

Irvine is an exciting place to study TFs, enhancers, and gene regulation!

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Reposted by Jongmin Kim

Seungsoo Kim @seungsookim.bsky.social · Jan 20

Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org

Kim Lab at UC Irvine

Visit the post for more.

sskimlab.org

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Jongmin Kim @jongminkmg.bsky.social · Dec 14

Indeed. I love the inducible chromatin contact experiment.

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