Lightnews — Scholar-powered news

Reposted by Joy Edwards-Hicks

Hansi Weissensteiner @whansi.bsky.social · May 22

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell

great work by Martin Picard

www.scientificamerican.com/article/why-...

The Hidden Social Lives of Mitochondria

When these energy-giving organelles thrive, so do we

www.scientificamerican.com

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Devon Greyson @greyson.bsky.social · May 20

Wow, incredibly promising preliminary data on real world use of RSV vaccinations.

Liz Szabo @lizszabo.bsky.social · May 20

RSV vaccinations decreased infant hospitalizations by 43%, may have helped lower infant mortality rates for whole population. www.cdc.gov/mmwr/volumes...

Interim Evaluation of Respiratory Syncytial ...

This report describes RSV-associated hospitalization rates among infants and young children during the 2024–25 respiratory virus season.

www.cdc.gov

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Liz Szabo @lizszabo.bsky.social · May 16

Great story from @jonelaleccia.bsky,social

apnews.com/article/zepb...

Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs

A new study shows that people Zepbound lost about 50% more weight than those using Wegovy. It was the first head-to-head trial of the blockbuster weight-loss medications.

apnews.com

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Sternberg Lab @sternberglab.bsky.social · May 15

1/10 Today in @science.org in collaboration with
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

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Maayan Visuals @maayanvisuals.bsky.social · Apr 30

Some cover art I made for a great paper about the body’s clock and biological aging! #SciArt

Björn Schumacher @bjornschumacher.bsky.social · Apr 30

Read here our original article showing the biological age prediction by accumulating stochastic variation alone. With @meyer.bsky.social and a wonderful cover art designed by @maayanvisuals.bsky.social www.nature.com/articles/s43...

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University and College Union (UCU) @ucu.org.uk · Apr 30

✊ Dundee Uni backs down from plans to cut 700 jobs after pressure from unions and the community.

Now they must take compulsory redundancies off the table.

Solidarity works.

UCU Scotland @ucuscotland.bsky.social · Apr 29

It’s a relief to see Dundee University backtrack on 700 job cuts. We now need the employer to take compulsory redundancies off the table #StopTheCuts @ducuuo.bsky.social
www.ucu.org.uk/article/1399...

UCU comment on University of Dundee alternative recovery plan

www.ucu.org.uk

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Jean Nakhle @jeannakhle.bsky.social · Apr 30

Paradoxically, both GIPR agonism and antagonism potentiate weight loss when paired with GLP-1R agonism. Two new studies in @natmetabolism.nature.com decode the different neural mechanisms employed by each strategy.

Check out the #News&Views by @adriaenssenslab.bsky.social here.

Nature Metabolism @natmetabolism.nature.com · Apr 29

Unravelling the GIPR agonist versus antagonist paradox

Nature Metabolism, Published online: 29 April 2025; doi:10.1038/s42255-025-01299-6The debate over whether to agonize or antagonize GIPR signalling has divided the obesity drug design field. Studies from Gutgesell et al. and Liu et al. represent important first steps towards disentangling divergent neural networks that explain the success of both strategies for promoting weight loss.

bit.ly

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The BMJ @bmj.com · Apr 30

The UK government is promoting a “strategic shift” from “treatment to prevention.”

Healthcare alone cannot restrain demand and prevention requires action on wider determinants of health, say
Vageesh Jain and Thomas Beaney www.bmj.com/content/389/...

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Miguel Branco @brancolab.bsky.social · Apr 23

So depressing...

Gabriel Bosslet @gbosslet.bsky.social · Apr 23

Well the NIH has cancelled the Women's Health Initiative, the largest study of women in history

It has been running continuously since 1991 and has provided massive key knowledge about diseases in women

Unreal

www.science.org/content/arti...

NIH cancels its first and largest study centered on women

The Women’s Health Initiative has produced numerous influential findings

www.science.org

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Matt Yousefzadeh @mattyousefzadeh.bsky.social · Apr 23

onlinelibrary.wiley.com/doi/10.1111/...

The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging

Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health-promoting trait (more common in women) linked to strong i....

onlinelibrary.wiley.com

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Isabel N Christie PhD @izzynchristie.bsky.social · Apr 22

#Hiring soon for a research assistant with a BSc in #pharmacology, #physiology or #biochemistry.

Looking for someone young and eager to learn, pre-PhD.

Job advert will go live in a few weeks

#newPI #Sheffield #neuroscience #brainbloodflow #CBF #science

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Jeffrey Perkel (he/him) @jperkel.bsky.social · Apr 22

I write about marimo, and how to choose the right programming language for your research, today in @nature.com www.nature.com/articles/d41...

Which programming language should I use? A guide for early-career researchers

Computer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice.

www.nature.com

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bioRxivpreprint @biorxivpreprint.bsky.social · Apr 21

Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2 https://www.biorxiv.org/content/10.1101/2025.04.19.649664v1

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Sean Mullen, Ph.D. @drseanmullen.bsky.social · Apr 21

179 experts. 28 countries. 1 message:

Long COVID is real, multi-systemic, and devastating. It affects over 400 million people. And we're not prepared.

New global consensus just dropped.

link.springer.com/content/pdf/10…

🧵

https://link.springer.com/content/pdf/10…

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Brandon Chen, PhD @brandontwchen.bsky.social · Apr 17

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell!

We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!

www.sciencedirect.com/science/arti...

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis

Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…

www.sciencedirect.com

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Christian Frezza @frezzalab.bsky.social · Apr 11

www.nature.com/articles/s42...

Metabolites are not genes. repeat, please!

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

www.nature.com

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Hansi Weissensteiner @whansi.bsky.social · Apr 11

Cells are swapping their mitochondria. What does this mean for our health?

www.nature.com/articles/d41...

Cells are swapping their mitochondria. What does this mean for our health?

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

www.nature.com

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Eric Topol @erictopol.bsky.social · Apr 10

It used to be thought that T-cell priming occurred as single phase. Now we know it takes two.
www.science.org/doi/10.1126/...
@science.org

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals

T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their diff...

www.science.org

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Matt Yousefzadeh @mattyousefzadeh.bsky.social · Mar 31

www.nature.com/articles/s41...

Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction - Nature Communications

MASLD is a growing global health concern. Here, the authors define a senescent hepatocyte gene signature (SHGS), demonstrate its clinical relevance, and identify senolytic therapies that selectively e...

www.nature.com

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Nature @nature.com · Mar 31

Scientists have created the first map of mitochondria throughout the entire brain

https://go.nature.com/4c8CLNM

First map of human brain mitochondria is ‘groundbreaking’ achievement

Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

go.nature.com

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Vikram Paralkar @paralkarlab.bsky.social · Mar 31

Check out this new podcast by my friend @anideshpande.bsky.social! It aims to delve into the history of groundbreaking discoveries in life, science and medicine. The first episode is a fascinating journey through our understanding of diabetes. I looking forward to future episodes!

E1 Diabetes Roots

YouTube video by Discovery Dialogues

www.youtube.com

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bioRxivpreprint @biorxivpreprint.bsky.social · Mar 31

Asymmetric phosphoinositide lipid bilayers generated by spontaneous lipid insertion https://www.biorxiv.org/content/10.1101/2025.03.26.645509v1

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🥖Kekeflipnote🥖 @kekeflipnote.bsky.social · Mar 30

Axolotls in your timeline!

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bioRxivpreprint @biorxivpreprint.bsky.social · Mar 31

Neutrophil progenitor cell therapy rescues host defense against Staphylococcus aureus in murine chronic granulomatous disease https://www.biorxiv.org/content/10.1101/2025.03.26.645550v1

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