jp flores (he/him)
@jpflores.rbind.io
🐏 phd’ing in bioinformatics & computational biology @ unc chapel hill | phanstiel lab | interests: genome org & function 🧬 | hhmi gilliam '24 | nsf grfp ‘22 | 🐅 occidental college ‘21 |🎙host, from where does it stem? | 🏘️ co-founder @sciforgood.bsky.social
Ramping back up post paper submission
December 23, 2025 at 4:34 PM
Ramping back up post paper submission
7/ Genes at these loop anchors activate hours after looping occurs, suggesting these structures may prime transcription, rather than trigger it immediately.
December 22, 2025 at 11:19 PM
7/ Genes at these loop anchors activate hours after looping occurs, suggesting these structures may prime transcription, rather than trigger it immediately.
6/ And they show a strong promoter bias enriched for SP/KLF motifs, suggesting an alternative mode of loop anchoring under hyperosmotic stress!
December 22, 2025 at 11:19 PM
6/ And they show a strong promoter bias enriched for SP/KLF motifs, suggesting an alternative mode of loop anchoring under hyperosmotic stress!
5/ These sorbitol-induced loops do not require CTCF or YAP1, but they do require cohesin (RAD21)
December 22, 2025 at 11:19 PM
5/ These sorbitol-induced loops do not require CTCF or YAP1, but they do require cohesin (RAD21)
4/ We see global loss of CTCF and cohesin binding, yet both are retained at anchors of these new loops
YAP1 is enriched there as well, pointing to selective architectural rewiring, not random chromatin compaction
YAP1 is enriched there as well, pointing to selective architectural rewiring, not random chromatin compaction
December 22, 2025 at 11:19 PM
4/ We see global loss of CTCF and cohesin binding, yet both are retained at anchors of these new loops
YAP1 is enriched there as well, pointing to selective architectural rewiring, not random chromatin compaction
YAP1 is enriched there as well, pointing to selective architectural rewiring, not random chromatin compaction
3/ These stress-induced loops are more punctate, longer-range, and transient
Most disappear by 24 hours as global chromatin structure recovers
Most disappear by 24 hours as global chromatin structure recovers
December 22, 2025 at 11:19 PM
3/ These stress-induced loops are more punctate, longer-range, and transient
Most disappear by 24 hours as global chromatin structure recovers
Most disappear by 24 hours as global chromatin structure recovers
2/ Within 1 hour, pre-existing loops collapse + a new, distinct class of sorbitol-induced loops emerges
December 22, 2025 at 11:19 PM
2/ Within 1 hour, pre-existing loops collapse + a new, distinct class of sorbitol-induced loops emerges
1/ Hyperosmotic stress doesn’t just change transcription - it rewires the 3D genome
Using time-resolved Hi-C, CUT&Tag, and auxin-inducible degrons, we tracked how 3D chromatin structure changes in human cells exposed to sorbitol
Using time-resolved Hi-C, CUT&Tag, and auxin-inducible degrons, we tracked how 3D chromatin structure changes in human cells exposed to sorbitol
December 22, 2025 at 11:19 PM
1/ Hyperosmotic stress doesn’t just change transcription - it rewires the 3D genome
Using time-resolved Hi-C, CUT&Tag, and auxin-inducible degrons, we tracked how 3D chromatin structure changes in human cells exposed to sorbitol
Using time-resolved Hi-C, CUT&Tag, and auxin-inducible degrons, we tracked how 3D chromatin structure changes in human cells exposed to sorbitol
Check out this interview from my longtime friend (since high school), Amanda Finn, in Forbes! Here, she talks about work we did for @snapcoalition.bsky.social’s Congressional District Visit Days!
Here in NC, we were able to meet with Rep. Deborah Ross + more!
www.forbes.com/sites/johndr...
Here in NC, we were able to meet with Rep. Deborah Ross + more!
www.forbes.com/sites/johndr...
December 3, 2025 at 10:49 PM
Check out this interview from my longtime friend (since high school), Amanda Finn, in Forbes! Here, she talks about work we did for @snapcoalition.bsky.social’s Congressional District Visit Days!
Here in NC, we were able to meet with Rep. Deborah Ross + more!
www.forbes.com/sites/johndr...
Here in NC, we were able to meet with Rep. Deborah Ross + more!
www.forbes.com/sites/johndr...
November 8, 2025 at 11:12 PM
A couple months ago, the Carolina Latinx Center reached out and asked if I’d be willing to help start a brand new STEM speaker series! I helped put together an all-star team, and we made it happen. I was PUMPED to have @cterminiphd.bsky.social come give a talk!
So inspiring!
So inspiring!
November 3, 2025 at 11:34 PM
A couple months ago, the Carolina Latinx Center reached out and asked if I’d be willing to help start a brand new STEM speaker series! I helped put together an all-star team, and we made it happen. I was PUMPED to have @cterminiphd.bsky.social come give a talk!
So inspiring!
So inspiring!
Went to my first @sacnas.bsky.social to give a talk about our work on the Atlas projects! Super thankful to be working with such passionate, kind people 🤠🫶🏽
November 3, 2025 at 11:31 PM
Went to my first @sacnas.bsky.social to give a talk about our work on the Atlas projects! Super thankful to be working with such passionate, kind people 🤠🫶🏽
I didn’t know what to expect out of Cleveland, but boy did it pop off!
Shoutout to @hhmi.org for bringing @raniaziar.bsky.social on! Such an amazing person & super grateful to know her hehe
Shoutout to @hhmi.org for bringing @raniaziar.bsky.social on! Such an amazing person & super grateful to know her hehe
November 3, 2025 at 11:29 PM
I didn’t know what to expect out of Cleveland, but boy did it pop off!
Shoutout to @hhmi.org for bringing @raniaziar.bsky.social on! Such an amazing person & super grateful to know her hehe
Shoutout to @hhmi.org for bringing @raniaziar.bsky.social on! Such an amazing person & super grateful to know her hehe
Also check out @jessbyun.bsky.social’s poster (she’s also in her last year and looking for her next opportunities!) and if you see Emma K from the @dphansti.bsky.social lab say hi! She’s working on MPRA for Osteoarthritis!
October 16, 2025 at 2:13 PM
Also check out @jessbyun.bsky.social’s poster (she’s also in her last year and looking for her next opportunities!) and if you see Emma K from the @dphansti.bsky.social lab say hi! She’s working on MPRA for Osteoarthritis!
I’m presenting my poster “Hyperosmotic stress induces a complete rewiring of chromatin interactions” at Board 8077T today (10/16) 2:30pm-4pm ET!
I’m wrapping up the PhD and on the postdoc market! Stop by and say hi!
I’m wrapping up the PhD and on the postdoc market! Stop by and say hi!
October 16, 2025 at 2:09 PM
I’m presenting my poster “Hyperosmotic stress induces a complete rewiring of chromatin interactions” at Board 8077T today (10/16) 2:30pm-4pm ET!
I’m wrapping up the PhD and on the postdoc market! Stop by and say hi!
I’m wrapping up the PhD and on the postdoc market! Stop by and say hi!
October 14, 2025 at 9:11 PM
Will never forget my interactions with Dr. Jane Goodall. RIP to a legend!
October 1, 2025 at 6:32 PM
Will never forget my interactions with Dr. Jane Goodall. RIP to a legend!
Excited to have these types of labels created by scientists all over the country!
September 27, 2025 at 1:24 AM
Excited to have these types of labels created by scientists all over the country!
Huge shoutout to @vangeliqueallen.bsky.social for co-leading this with me and others from @sciforgood.bsky.social !
Pilot sites are well on their way!
Pilot sites are well on their way!
September 27, 2025 at 1:22 AM
Huge shoutout to @vangeliqueallen.bsky.social for co-leading this with me and others from @sciforgood.bsky.social !
Pilot sites are well on their way!
Pilot sites are well on their way!
Excited to announce the release of the Loopapalooza Pale Ale & Fold Skool Fizz Seltzer (non-alcoholic) on tap and in cans at both Steel String Brewery Taproom in Carrboro, NC and at Pluck Farm in Mebane, NC!
Thanks to @researchamerica.bsky.social for having these at your event last week!
Thanks to @researchamerica.bsky.social for having these at your event last week!
September 27, 2025 at 1:22 AM
Excited to announce the release of the Loopapalooza Pale Ale & Fold Skool Fizz Seltzer (non-alcoholic) on tap and in cans at both Steel String Brewery Taproom in Carrboro, NC and at Pluck Farm in Mebane, NC!
Thanks to @researchamerica.bsky.social for having these at your event last week!
Thanks to @researchamerica.bsky.social for having these at your event last week!
Felt rejuvenated after this year’s Annual @hhmi.org Gilliam Conference! Was so nice being with the future of science again 😊 great time sharing my story, playing music, and telling everyone the hot gossip with the happenings of the year 🤭
expecting a lot of @sciforgood.bsky.social contributions 🤗
expecting a lot of @sciforgood.bsky.social contributions 🤗
September 27, 2025 at 1:17 AM
Felt rejuvenated after this year’s Annual @hhmi.org Gilliam Conference! Was so nice being with the future of science again 😊 great time sharing my story, playing music, and telling everyone the hot gossip with the happenings of the year 🤭
expecting a lot of @sciforgood.bsky.social contributions 🤗
expecting a lot of @sciforgood.bsky.social contributions 🤗
Great conversation with Representative Deborah Ross today, along with students from NC State!
Great conversations re: multi year funding, the NSF GRFP, @sciforgood.bsky.social, international student scientists, @snapcoalition.bsky.social and more!
Great conversations re: multi year funding, the NSF GRFP, @sciforgood.bsky.social, international student scientists, @snapcoalition.bsky.social and more!
September 27, 2025 at 1:14 AM
Great conversation with Representative Deborah Ross today, along with students from NC State!
Great conversations re: multi year funding, the NSF GRFP, @sciforgood.bsky.social, international student scientists, @snapcoalition.bsky.social and more!
Great conversations re: multi year funding, the NSF GRFP, @sciforgood.bsky.social, international student scientists, @snapcoalition.bsky.social and more!