jp flores (he/him)
@jpflores.rbind.io
🐏 phd’ing in bioinformatics & computational biology @ unc chapel hill | phanstiel lab | interests: genome org & function 🧬 | hhmi gilliam '24 | nsf grfp ‘22 | 🐅 occidental college ‘21 |🎙host, from where does it stem? | 🏘️ co-founder @sciforgood.bsky.social
Ramping back up post paper submission
December 23, 2025 at 4:34 PM
Ramping back up post paper submission
7/ Genes at these loop anchors activate hours after looping occurs, suggesting these structures may prime transcription, rather than trigger it immediately.
December 22, 2025 at 11:19 PM
7/ Genes at these loop anchors activate hours after looping occurs, suggesting these structures may prime transcription, rather than trigger it immediately.
6/ And they show a strong promoter bias enriched for SP/KLF motifs, suggesting an alternative mode of loop anchoring under hyperosmotic stress!
December 22, 2025 at 11:19 PM
6/ And they show a strong promoter bias enriched for SP/KLF motifs, suggesting an alternative mode of loop anchoring under hyperosmotic stress!
5/ These sorbitol-induced loops do not require CTCF or YAP1, but they do require cohesin (RAD21)
December 22, 2025 at 11:19 PM
5/ These sorbitol-induced loops do not require CTCF or YAP1, but they do require cohesin (RAD21)
4/ We see global loss of CTCF and cohesin binding, yet both are retained at anchors of these new loops
YAP1 is enriched there as well, pointing to selective architectural rewiring, not random chromatin compaction
YAP1 is enriched there as well, pointing to selective architectural rewiring, not random chromatin compaction
December 22, 2025 at 11:19 PM
4/ We see global loss of CTCF and cohesin binding, yet both are retained at anchors of these new loops
YAP1 is enriched there as well, pointing to selective architectural rewiring, not random chromatin compaction
YAP1 is enriched there as well, pointing to selective architectural rewiring, not random chromatin compaction
3/ These stress-induced loops are more punctate, longer-range, and transient
Most disappear by 24 hours as global chromatin structure recovers
Most disappear by 24 hours as global chromatin structure recovers
December 22, 2025 at 11:19 PM
3/ These stress-induced loops are more punctate, longer-range, and transient
Most disappear by 24 hours as global chromatin structure recovers
Most disappear by 24 hours as global chromatin structure recovers
2/ Within 1 hour, pre-existing loops collapse + a new, distinct class of sorbitol-induced loops emerges
December 22, 2025 at 11:19 PM
2/ Within 1 hour, pre-existing loops collapse + a new, distinct class of sorbitol-induced loops emerges
Will never forget my interactions with Dr. Jane Goodall. RIP to a legend!
October 1, 2025 at 6:32 PM
Will never forget my interactions with Dr. Jane Goodall. RIP to a legend!