jp flores (he/him)
@jpflores.rbind.io
🐏 phd’ing in bioinformatics & computational biology @ unc chapel hill | phanstiel lab | interests: genome org & function 🧬 | hhmi gilliam '24 | nsf grfp ‘22 | 🐅 occidental college ‘21 |🎙host, from where does it stem? | 🏘️ co-founder @sciforgood.bsky.social
Pinned
jp flores (he/him)
@jpflores.rbind.io
· Nov 17
jp flores
phd candidate in bioinformatics & computational biology at unc chapel hill
jpflores.rbind.io
#Introductions
Hi! 🤠 I’m JP (he/him), and I’m a PhD candidate at UNC Chapel Hill studying the role of 3D chromatin structure in response to environmental stress 🧬
I host the From where does it STEM? podcast, write/edit for GeneBites, & more!
website: jpflores.rbind.io
instagram: @jpflores_31
Hi! 🤠 I’m JP (he/him), and I’m a PhD candidate at UNC Chapel Hill studying the role of 3D chromatin structure in response to environmental stress 🧬
I host the From where does it STEM? podcast, write/edit for GeneBites, & more!
website: jpflores.rbind.io
instagram: @jpflores_31
Reposted by jp flores (he/him)
This is one for the It Explains So Much files: a new study on how children have early gender biases in paying more attention to numerical information from men than women AND false male answers win out over correct female answers
January 10, 2026 at 4:31 PM
This is one for the It Explains So Much files: a new study on how children have early gender biases in paying more attention to numerical information from men than women AND false male answers win out over correct female answers
Reposted by jp flores (he/him)
X and Y chromosomes don’t drive binary opposing outcomes. Senior Editor @jpflores.rbind.io discusses a study that found additional Y or inactive X chromosomes in cells affect activity of some genes 🧬 similarly.
#genetics #BeyondTheBinary #scicomm
Check it out here: genebites.org/2026/01/08/t...
#genetics #BeyondTheBinary #scicomm
Check it out here: genebites.org/2026/01/08/t...
The X and Y Divide Isn’t Binary
The X and Y chromosomes split hundreds of millions of years ago and seem to live very different lives. But new research shows they still regulate the same genes across the genome, quietly shaping b…
genebites.org
January 9, 2026 at 4:15 PM
X and Y chromosomes don’t drive binary opposing outcomes. Senior Editor @jpflores.rbind.io discusses a study that found additional Y or inactive X chromosomes in cells affect activity of some genes 🧬 similarly.
#genetics #BeyondTheBinary #scicomm
Check it out here: genebites.org/2026/01/08/t...
#genetics #BeyondTheBinary #scicomm
Check it out here: genebites.org/2026/01/08/t...
If anyone has any dissertation writing tips, throw em at me! The time has come! 🤠
January 5, 2026 at 9:59 PM
If anyone has any dissertation writing tips, throw em at me! The time has come! 🤠
Reposted by jp flores (he/him)
It's bittersweet to describe the success of #NIHPREP Scholars. You are awesome #scientists. Don't let anyone tell you otherwise. www.biorxiv.org/content/10.6...
PREP-aring is worth it: Success of the Case Western Reserve University Post-baccalaureate Research Education Program and its Scholars
The Post-baccalaureate Research Education Program (PREP), established by the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health in 2000, was a research-intense...
www.biorxiv.org
January 3, 2026 at 2:02 PM
It's bittersweet to describe the success of #NIHPREP Scholars. You are awesome #scientists. Don't let anyone tell you otherwise. www.biorxiv.org/content/10.6...
Reposted by jp flores (he/him)
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
Reposted by jp flores (he/him)
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
www.nature.com
December 17, 2025 at 8:59 PM
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by jp flores (he/him)
As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below
Know of a relevant event that’s missing? Please reply below
Conferences & Schools – 2026 – Gene Regulation – Teif Lab
generegulation.org
December 29, 2025 at 3:29 PM
As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below
Know of a relevant event that’s missing? Please reply below
Reposted by jp flores (he/him)
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
December 24, 2025 at 10:44 PM
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
Reposted by jp flores (he/him)
OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
Notice of Request for Information; Accelerating the American Scientific Enterprise
The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...
www.federalregister.gov
December 23, 2025 at 10:56 PM
OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
My committee >>>
Awesome--see you at the committee meeting after the holidays--enjoy some well deserved time off!
December 23, 2025 at 1:44 AM
My committee >>>
Reposted by jp flores (he/him)
Awesome--see you at the committee meeting after the holidays--enjoy some well deserved time off!
December 23, 2025 at 1:36 AM
Awesome--see you at the committee meeting after the holidays--enjoy some well deserved time off!
Reposted by jp flores (he/him)
Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping https://www.biorxiv.org/content/10.64898/2025.12.19.695003v1
December 22, 2025 at 10:32 PM
Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping https://www.biorxiv.org/content/10.64898/2025.12.19.695003v1
Excited to finally share what I’ve been working on during my PhD 😊 Best holiday gift EVER!
We just posted a new preprint from the @dphansti.bsky.social 👇
Preprint: www.biorxiv.org/content/10.6...
🧵
We just posted a new preprint from the @dphansti.bsky.social 👇
Preprint: www.biorxiv.org/content/10.6...
🧵
Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping
Cells continually encounter environmental stressors that challenge homeostasis. How three-dimensional (3D) chromatin structure contributes to these stress responses, particularly under hyperosmotic co...
www.biorxiv.org
December 22, 2025 at 11:19 PM
Excited to finally share what I’ve been working on during my PhD 😊 Best holiday gift EVER!
We just posted a new preprint from the @dphansti.bsky.social 👇
Preprint: www.biorxiv.org/content/10.6...
🧵
We just posted a new preprint from the @dphansti.bsky.social 👇
Preprint: www.biorxiv.org/content/10.6...
🧵
Just submitted my main PhD project today! biorxiv post coming soon! 🤠🤠🤠
December 19, 2025 at 3:41 PM
Just submitted my main PhD project today! biorxiv post coming soon! 🤠🤠🤠
Reposted by jp flores (he/him)
Unfortunately the drop in ESI funding rates is not paired with changes in funding required to get tenure. It’s not just the next three years of our labs at risk, but the rest of our careers. We are also the cohort that started in the COVID pandemic- it’s been nothing but “unprecedented times”…
December 19, 2025 at 2:16 AM
Unfortunately the drop in ESI funding rates is not paired with changes in funding required to get tenure. It’s not just the next three years of our labs at risk, but the rest of our careers. We are also the cohort that started in the COVID pandemic- it’s been nothing but “unprecedented times”…
Reposted by jp flores (he/him)
Reposted by jp flores (he/him)
Rebuilding trust in science requires people to see themselves in science: expanding representation and social connection across race, gender, class, religion, and rural identity, not just sharing more information.
Representation in science and trust in scientists in the USA - Nature Human Behaviour
Druckman et al. document gaps in trust in scientists in the USA. People from groups less represented among scientists (for example, women and those with lower economic status) are less trusting. Incre...
www.nature.com
December 15, 2025 at 4:23 PM
Rebuilding trust in science requires people to see themselves in science: expanding representation and social connection across race, gender, class, religion, and rural identity, not just sharing more information.
Reposted by jp flores (he/him)
Did we infer 3D chromatin function a TAD too early?
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
TAD boundary architecture and gene activity are uncoupled
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...
www.biorxiv.org
December 18, 2025 at 8:02 PM
Did we infer 3D chromatin function a TAD too early?
Reposted by jp flores (he/him)
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
TAD boundary architecture and gene activity are uncoupled
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...
www.biorxiv.org
December 18, 2025 at 11:43 AM
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
Reposted by jp flores (he/him)
All the centers they’re cutting add up to less than $7 million in spending.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
December 18, 2025 at 12:45 AM
All the centers they’re cutting add up to less than $7 million in spending.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
Reposted by jp flores (he/him)
CiFi: accurate long-read chromosome conformation capture with low-input requirements. #HiFi #LongRead #Sequencing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 16, 2025 at 11:30 AM
CiFi: accurate long-read chromosome conformation capture with low-input requirements. #HiFi #LongRead #Sequencing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by jp flores (he/him)
In a new guest article for the @pspdg.bsky.social blog, I explore the history of eugenics, its lingering impacts on society, and the potential of educational strategies to undermine false beliefs about genetics: www.pspdg.com/blog/2025/12...
Thanks to the blog team for their help with editing!
Thanks to the blog team for their help with editing!
What Remains Of Eugenics: The Legacy Of “Improving” The Human Breeding Stock — Penn Science Policy and Diplomacy Group
Guest post by Amanda N. Weiss People have long used selective breeding of crops and livestock to produce food and work animals with traits suited for our purposes. But ideas about good breeding stoc...
www.pspdg.com
December 16, 2025 at 7:01 PM
In a new guest article for the @pspdg.bsky.social blog, I explore the history of eugenics, its lingering impacts on society, and the potential of educational strategies to undermine false beliefs about genetics: www.pspdg.com/blog/2025/12...
Thanks to the blog team for their help with editing!
Thanks to the blog team for their help with editing!
Reposted by jp flores (he/him)
"At least two of the Brown University students who were on campus when a deadly shooting unfolded there on Saturday have survived school shootings before."
2 Students at Brown Witnessed School Shootings as Children
www.nytimes.com
December 14, 2025 at 3:09 PM
"At least two of the Brown University students who were on campus when a deadly shooting unfolded there on Saturday have survived school shootings before."
Reposted by jp flores (he/him)
One argument I used to make to my students about why it was important to learn history (and historical thinking) is that someone was always going to be trying to tell you things were natural or had always been this way and that you needed to be able to see that as an exercise of power.
December 7, 2025 at 10:09 PM
One argument I used to make to my students about why it was important to learn history (and historical thinking) is that someone was always going to be trying to tell you things were natural or had always been this way and that you needed to be able to see that as an exercise of power.
Reposted by jp flores (he/him)
I wrote a guide on constructive peer review. This is a polished version of an internal guide I had for my group. Of course, constructive feedback is welcome, peers!
deboer.bme.ubc.ca/2025/12/09/g...
deboer.bme.ubc.ca/2025/12/09/g...
December 9, 2025 at 6:38 PM
I wrote a guide on constructive peer review. This is a polished version of an internal guide I had for my group. Of course, constructive feedback is welcome, peers!
deboer.bme.ubc.ca/2025/12/09/g...
deboer.bme.ubc.ca/2025/12/09/g...