jsbeckwith.bsky.social
Joe Beckwith
@jsbeckwith.bsky.social
500 followers 280 following 26 posts
Spectroscopist, microscopist, pessimist. SRA in the Cambridge Chemistry Department. Science and/or nonsense. Occasionally a post about personal matters, instantly regretted. he/him | 🏳️‍🌈
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jsbeckwith.bsky.social
Joe Beckwith @jsbeckwith.bsky.social · 7d
www.nature.com/articles/s41...

It's out at last! Work that I was totally privileged to be a part of led by @becs-andrews.bsky.social, with @jcbreiter.bsky.social @stevethechemist.bsky.social and funded by @asapresearch.parkinsonsroadmap.org
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue - Nature Biomedical Engineering
An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.
www.nature.com
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Reposted by Joe Beckwith
uendesfelder.bsky.social
Ulrike Endesfelder @uendesfelder.bsky.social · 27d
Please share: The application for Les Houches is open (until Oct 31)

fluorescenceleshouches.wordpress.com

*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*

PS: no fees this year, you just need to get there, that's all!
French-German WE-Heraeus-Seminar "Fluorescence markers for advanced microscopy : From photophysics to biology - 2026"
March 15-20 2026, Les Houches, France
fluorescenceleshouches.wordpress.com
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Reposted by Joe Beckwith
lines.snail.skin
ʟɪɴᴇs @lines.snail.skin · Sep 3
I am finding the fact that "is it acceptable and proportional to call for trans women to be assaulted in public" is now a subject of public debate in the UK really very upsetting.
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Reposted by Joe Beckwith
jamesrevans.bsky.social
James R Evans @jamesrevans.bsky.social · Sep 1
Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.

www.biorxiv.org/content/10.1...

Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Parkinson's disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late...
www.biorxiv.org
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Reposted by Joe Beckwith
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · Sep 1
Single-Molecule Friends! Just 10 more days to apply for an exciting joint postdoc with @KlenermanLab, feel free to research out www.ch.cam.ac.uk/job/52425
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term) | Yusuf Hamied Department of Chemistry
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for a...
www.ch.cam.ac.uk
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Reposted by Joe Beckwith
biorxiv-neursci.bsky.social
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Aug 28
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.08.25.671921v1
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jsbeckwith.bsky.social
Joe Beckwith @jsbeckwith.bsky.social · Aug 19
Lovely bit of business this wordplay
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Reposted by Joe Beckwith
stevethechemist.bsky.social
Prof Steven Lee @stevethechemist.bsky.social · Aug 14
Build microscopes, solve immunology (kinda)... come and work with us! We have an exciting collaborative postdoc position in the group. www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term)
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for
www.cam.ac.uk
2
jsbeckwith.bsky.social
Joe Beckwith @jsbeckwith.bsky.social · Aug 12
Cool work from a cool lab!
micoxscopy.bsky.social
Susan Cox @micoxscopy.bsky.social · Aug 12
How do you quantify cell structures which are deformed between different observations? Our preprint shows how to perform Simultaneous QUAntification of Structure and Structural Heterogeneity (SQUASSH) on 3D fluorescence microscopy data. (1/5)
www.biorxiv.org/content/10.1...
Extracting biological structure and heterogeneity from the nano to the macro scale
Fluorescence microscopy is an essential tool in biology. It has revealed great variability at multiple scales, in macromolecular complexes, cells, and organisms. Understanding this variability will re...
www.biorxiv.org
Reposted by Joe Beckwith
brunlabcaulo.bsky.social
Yves Brun lab @brunlabcaulo.bsky.social · Jul 9
Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...
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Reposted by Joe Beckwith
kaksonen.bsky.social
Marko Kaksonen @kaksonen.bsky.social · Jul 7
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).

Please apply and/or repost!

jobs.unige.ch/www/wd_porta...
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jsbeckwith.bsky.social
Joe Beckwith @jsbeckwith.bsky.social · Jun 27
Why have I done this ridiculous pose
zwijcompchem.bsky.social
Martijn Zwijnenburg @zwijcompchem.bsky.social · Jun 27
Joseph Beckwith from Cambridge gave the first invited talk of the 2nd day of the @rsc-photochem.bsky.social ECR meeting talking about multicolour single molecule spectroscopy.

#chemsky #fluoresence
A picture of Joseph giving his talk
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Reposted by Joe Beckwith
samofmidworld.bsky.social
Sam Daly @samofmidworld.bsky.social · Jun 10
Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social
biorxiv-biophys.bsky.social
bioRxiv Biophysics @biorxiv-biophys.bsky.social · Jun 10
Volumetric single-molecule tracking inside subcellular structures https://www.biorxiv.org/content/10.1101/2025.06.09.658280v1
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Reposted by Joe Beckwith
andrewplested.bsky.social
Andrew Plested @andrewplested.bsky.social · Jun 5
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at [email protected]. Fee waivers and bursaries available.

! Please share widely !
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jsbeckwith.bsky.social
Joe Beckwith @jsbeckwith.bsky.social · May 1
www.rsc.org/events/detai...

Come to this meeting magnificently organised by @rsc-photochem.bsky.social! Abstract deadline May 30, conference is 26–27 June in London, and I am baffled and happy to be an invited speaker alongside some really great people.

#photochem #photophysics #microscopy
Photophysics and Photochemistry Group Early Career Meeting 2025
www.rsc.org
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Reposted by Joe Beckwith
jamesmcenaney.bsky.social
James McEnaney @jamesmcenaney.bsky.social · Apr 22
Section 28 was "the law" too - that doesn't change the fact that the people who supported it were doing so out of bigotry.
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Reposted by Joe Beckwith
amnestyuk.bsky.social
Amnesty International UK @amnestyuk.bsky.social · Apr 19
Today, thousands gathered across the country - from Hastings to London to Glasgow - to say: we will always stand with trans people.

Trans rights are human rights. 🏳️‍⚧️
Someone holding a sign saying: Respect existence or expect resistance. Parents holding up a sign saying: "this mum says trans rights are human rights" and "our beautiful daughter is trans." Someone holding a sign saying "you can't legislate us out of existence." Someone holding a sign saying "i love my trans self. I love my trans friends."
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Reposted by Joe Beckwith
xinshi-o.bsky.social
Xin Shi @xinshi-o.bsky.social · Apr 18
🚨We have a 4-year ERC-funded PhD position available in the beautiful city of Leuven, Belgium, for building artificial nanomachines in lipid membranes.

Check out the details and apply here: www.kuleuven.be/personeel/jo...

Feel free to email me for more information!
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Reposted by Joe Beckwith
natprot.nature.com
Nature Protocols @natprot.nature.com · Apr 17
Today we share our Collection on protocols describing how to build and operate a broad variety of microscopy setups.

Let us know which one is your favourite microscope?

🧪 🔬
Microscopy setup protocols
A collection of Protocols and Tutorials covering a range of microscopy approaches, and including the build of microscopy setups and the use of microscopy ...
bit.ly
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Reposted by Joe Beckwith
earlymodernjohn.bsky.social
John Gallagher @earlymodernjohn.bsky.social · Apr 16
A fringe group of bigoted weirdos have dragged British media, government, and law into their hateful obsession with trans people. Grim, depressing, and dangerous. Everyone with power in the UK who's played along should be ashamed of themselves.
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jsbeckwith.bsky.social
Joe Beckwith @jsbeckwith.bsky.social · Apr 1
Hi all---I sadly cannot make it to #FOM2025, would anybody want to take my registration? Feel free to ping me on here/forward to possibly interested people.
Reposted by Joe Beckwith
micro-manager.bsky.social
micro-manager.bsky.social @micro-manager.bsky.social · Mar 29
Just had the pleasure to experiment with a camera targeting the astronomy market, but offering great value for microscopy. Cooled, low noise (<1.5 e read-noise), high QE cameras that work with Micro-Manager can be bought for ~$1k: nicost.github.io/microscope-t...
PlayerOne cooled CMOS camera
The Sony STARVIS and STARVIS2 image sensors are back-illuminated, have high QE and low readnoise (where STARVIS2 increases full well depth over STARVIS). Even though these sensors are marketed towards...
nicost.github.io
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jsbeckwith.bsky.social
Joe Beckwith @jsbeckwith.bsky.social · Mar 21
www.google.com/books/editio...

perhaps?
Molecular Kinetics in Condensed Phases
A guide to the theoretical and computational toolkits for the modern study of molecular kinetics in condensed phases Molecular Kinetics in Condensed Phases: Theory, Simulation and Analysis puts the fo...
www.google.com
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Reposted by Joe Beckwith
jytinevez.bsky.social
Jean-Yves Tinevez @jytinevez.bsky.social · Mar 11
Do you want to learn #BioimageAnalysis? Do you want to strengthen your skills?

We're thrilled to announce the #NEUBIAS Pasteur Course on Bioimage Analysis - May 2025! in @pasteur.fr Paris!

research.pasteur.fr/en/course/ne...

Details are on the page linked here, some info below 👇
NEUBIAS Pasteur course on Bioimage Analysis - 2025 - Research
Topics The exact schedule is still being finalized. Here is a description of the course content. Both tracks of the course have a specific focus on hands-on and interactive tutorials. They are meant t...
research.pasteur.fr
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Reposted by Joe Beckwith
amsikking.bsky.social
Alfred Millett-Sikking @amsikking.bsky.social · Feb 25
Microscope objectives can be confusing, and detailed specs (or even basic properties) are often hard to find. Here's an introductory resource to help new builders and instrument designers with the basics. It's a work in progress so feedback is appreciated:

amsikking.github.io/microscope_o...
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