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Reposted by Jonathan VanRyzin

Ryan McLaughlin @ryanmcpickle.bsky.social · 27d

Science friends! I need your help. We have a Neurophotometrics FP system that we are having trouble integrating with behavioral tracking software for annotation purposes. For example, we want to align fluorescence with open/closed arm exploration in the EPM. Can you help us out??

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Reposted by Jonathan VanRyzin

Travis Faust @travisfaust.bsky.social · 26d

Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”

This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.

🔗 www.cell.com/cell/fulltex...

Faust et al., Cell 2025

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Jonathan VanRyzin @jwvanryzin.bsky.social · 26d

Congrats! Fantastic work!

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Reposted by Jonathan VanRyzin

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Aug 26

Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities
www.sciencedirect.com/science/arti...

Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities

Prenatal stress (PNS) is a well-established risk factor for psychiatric disorders, yet the underlying neurobiological mechanisms remain unclear. Here,…

www.sciencedirect.com

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Reposted by Jonathan VanRyzin

Maxwell Madden @maxwellmadden.bsky.social · Aug 21

Excited my PhD work in @brianmathur.bsky.social’s lab is now published and available!

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Aug 20

Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum
doi.org/10.1038/s414...

Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum - Nature Communications

Our basic understanding of neuromodulation in the claustrum remains limited. Here Madden et al., identify a key mechanism by which serotonin and the psychedelic psilocybin modulate cortical signalling...

doi.org

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Jonathan VanRyzin @jwvanryzin.bsky.social · Aug 20

Thank you!

Reposted by Jonathan VanRyzin

Elena Blanco-Suárez @eblancosuarez.bsky.social · Aug 14

If you have a "recently" (in the last 2 years) published paper with a preprint available, I’d love to hear from you!

All neuroscience topics are welcome.

🙏🏼 Thank you!

Elena Blanco-Suárez @eblancosuarez.bsky.social · Aug 14

I’m designing a course that uses preprints and their peer-reviewed, published versions to directly compare how manuscripts are originally conceived by authors and how the peer-review process shapes their final form.🎯My goal is to help students strengthen critical thinking and become fair reviewers.

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Jonathan VanRyzin @jwvanryzin.bsky.social · Aug 13

This was a huge collaborative effort with Anze Testen and Tania Bellinger, and a big shout out to @haleyv.bsky.social and Ève Tremblay for their electron microscopy expertise!

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Jonathan VanRyzin @jwvanryzin.bsky.social · Aug 13

I am SO EXCITED to share this one! The latest paper from the lab is online in @cp-cellreports.bsky.social. We show microglia prune NAc astrocyte processes during abstinence from cocaine-self ad which drives later drug seeking behavior.

www.sciencedirect.com/science/arti...

Abstinence from cocaine self-administration promotes microglial pruning of astrocytes, which drives cocaine-seeking behavior

Rodent drug self-administration leads to a compromised ability of nucleus accumbens astrocytes to maintain glutamate homeostasis as well as to reducti…

www.sciencedirect.com

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Jonathan VanRyzin @jwvanryzin.bsky.social · Aug 6

This project will explore how early life adversity impairs circuit-specific astrocyte-neuron interactions in the nucleus accumbens and identify the molecular mechanisms of astrocyte dysfunction that lead to addiction susceptibility

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Jonathan VanRyzin @jwvanryzin.bsky.social · Aug 6

Incredibly grateful to be one of the 2025 BBRF Young Investigator Grant awardees!
Thank you to @bbrfoundation.bsky.social and to my mentors for their support along the way!

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Reposted by Jonathan VanRyzin

Dr. Cate Peña @cate-cholamine.bsky.social · Aug 6

Review now out in @npp-journal.bsky.social!
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq

Epigenetic regulation of brain development, plasticity, and response to early-life stress

Neuropsychopharmacology - Epigenetic regulation of brain development, plasticity, and response to early-life stress

rdcu.be

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Reposted by Jonathan VanRyzin

Neuropsychopharmacology @npp-journal.bsky.social · Aug 5

#ThisWeekInNPP

This study explored how prenatal & postnatal THC exposure affects 🧠 development & social behavior in 🐭, highlighting an impact on microglial phagocytosis in the developing amygdala in a sex-specific & timing-dependent manner ⏲️ / @jwvanryzin.bsky.social

Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology

Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

www.nature.com

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Jonathan VanRyzin @jwvanryzin.bsky.social · Jul 29

Huge thank you to everyone on the project!! @aidanlpham.bsky.social @kristenmontgomery.bsky.social @aemarquardt.bsky.social @pegmccarthy.bsky.social @um-mind.bsky.social

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Jonathan VanRyzin @jwvanryzin.bsky.social · Jul 29

Excited to see our most recent project published in @npp-journal.bsky.social !
We show that the timing of THC exposure during development—prenatal vs. postnatal—leads to opposite effects on social behavior and microglial function in the amygdala. Timing matters!

www.nature.com/articles/s41...

Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology

Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

www.nature.com

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Reposted by Jonathan VanRyzin

pegmccarthy.bsky.social @pegmccarthy.bsky.social · Jul 23

Excited to announce our latest production! @jwvanryzin.bsky.social @aemarquardt.bsky.social @um-mind.bsky.social www.nature.com/articles/s41...

Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology

Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

www.nature.com

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Jonathan VanRyzin @jwvanryzin.bsky.social · Nov 22

Happy #FluorescenceFriday !

Sharing one of my favorite images I've taken of microglia phagocytosis featuring a neuron whose DAPI is all too happy to be eaten.

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Jonathan VanRyzin @jwvanryzin.bsky.social · Nov 14

Thank you!

Reposted by Jonathan VanRyzin

Shane Liddelow @liddelowsa.bsky.social · Nov 14

go.bsky.app/Lyzro3M

!WELCOME!

thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.

apologies for missing many of you - please do reply to get added

and remember to repost so the newbies can find us!

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Jonathan VanRyzin @jwvanryzin.bsky.social · Nov 14

In doing so, we can estimate the number of synapses that an astrocyte interacts with and determine how many of those are circuit-specific.

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Jonathan VanRyzin @jwvanryzin.bsky.social · Nov 14

I've been trying something a bit different on the microscope lately. Looking at ways we can model physical interactions of astrocytes with specific neural circuits across development.

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Jonathan VanRyzin @jwvanryzin.bsky.social · Nov 12

Finally made the migration!

To any new faces, I'm Jon and I'm a postdoc at UNC studying microglia, astrocytes, brain development, stress, and addiction. I'm also on the job market!

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