Krell et al. show that mTORC1 in β cells acts as an activity sensor, activated by the same signals that trigger insulin secretion. This activation, in turn, inhibits insulin release via RhoA-dependent...

Nature Metabolism, Published online: 29 April 2025; doi:10.1038/s42255-025-01299-6The debate over whether to agonize or antagonize GIPR signalling has divided the obesity drug design field. Studies from Gutgesell et al. and Liu et al. represent important first steps towards disentangling divergent neural networks that explain the success of both strategies for promoting weight loss.