Lightnews — Scholar-powered news

Karen Slattery @karen--s.bsky.social · Jun 12

Delighted to have our work on ovarian cancer highlighted by Cancer Discovery News this week! 😊

Lisa Situ @lisasitu.bsky.social · Jun 11

ICYMI: Ascites-derived Lipid Uptake Drives NK Cell Dysfunction in Ovarian Cancer, a #ResearchWatch summary of a new study by @karen--s.bsky.social, @lydialynch.bsky.social, and colleagues at @ludwigcancer.bsky.social @princetonmolbio.bsky.social

aacrjournals.org/cdnews/news/...

Ascites-derived Lipid Uptake Drives NK Cell Dysfunction in Ovarian Cancer

Major Finding: Lipids derived from ascites are taken up by NK cells and drive NK cell dysfunction in ovarian cancer. Concept: Polar lipids such as phosphatidylcholine disrupt NK plasma membrane order ...

aacrjournals.org

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Karen Slattery @karen--s.bsky.social · May 12

Thrilled to share our new study showing that lipids drive immune dysfunction in ovarian cancer — and that blocking lipid uptake through SR-B1 can prevent it! @lydialynch.bsky.social @tcddublin.bsky.social

Ludwig Cancer Research @ludwigcancer.bsky.social · May 9

Researchers led by Ludwig Princeton’s @lydialynch.bsky.social report that certain fats in ascites fluid—which accumulates as ovarian cancer spreads from the ovaries into the abdomen—sabotage anti-tumor immune responses and show how this effect might be blocked for immunotherapy. bit.ly/4jGuUtU

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Reposted by Karen Slattery

Lydia Lynch @lydialynch.bsky.social · May 12

Our paper @sciimmunology.bsky.social shows certain lipids are responsible for the immunosupression of ascites & propose blocking lipid uptake thru SCARB1 may help immunotherapy in ovarian cancer. Wonderful to collaborate with Donal Brennan, Marcia Haigis & super postdoc @karen--s.bsky.social

Ludwig Cancer Research @ludwigcancer.bsky.social · May 9

Researchers led by Ludwig Princeton’s @lydialynch.bsky.social report that certain fats in ascites fluid—which accumulates as ovarian cancer spreads from the ovaries into the abdomen—sabotage anti-tumor immune responses and show how this effect might be blocked for immunotherapy. bit.ly/4jGuUtU

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Karen Slattery @karen--s.bsky.social · Mar 3

Lovely work, congrats to all! 😊

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Karen Slattery @karen--s.bsky.social · Feb 24

I was honored to recieve the Translational Project of the Year Award at the Irish Cancer Society Awards last week! Thanks so much to the ICS for funding and acknowledging this work, and to @lydialynch.bsky.social for all of the support over the years! 😊🥰

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Reposted by Karen Slattery

Delgoffe Lab @delgoffelab.bsky.social · Jan 28

I'm delighted to share a new story from our lab published today at @cp-cellmetabolism.bsky.social! In it, we describe how cellular therapies for cancer can be metabolically and epigenetically enhanced by redirecting how glucose is utilized during in vitro expansion. 1/ www.cell.com/cell-metabol...

Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy

T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive aerobic glycolysis. Rer...

www.cell.com

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Reposted by Karen Slattery

Isaac Harris @harrislab.bsky.social · Jan 23

I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC.

I'm excited to come together, talk science, and support researchers in our field.

www.cancermetabolismshowcase.org

9:30 AM - 3 PM EST, May 5th and 6th, 2025

www.cancermetabolismshowcase.org

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Karen Slattery @karen--s.bsky.social · Jan 20

Definitely, super cool study!

Reposted by Karen Slattery

Wallace Marshall @wallaceucsf.bsky.social · Dec 23

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...

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Karen Slattery @karen--s.bsky.social · Jan 13

Original study here 😊

GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency - Nature Communications

T cell activation is a process that requires extra nutrients, which could be difficult to source from the tumor microenvironment in competition with tumor cells. Here authors increase the metabolic fi...

www.nature.com

Karen Slattery @karen--s.bsky.social · Jan 13

Check out our new commentary on this interesting study by @justinaguerrero.bsky.social and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells!
@davidfinlaytcd.bsky.social

La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism

y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...

journals.lww.com

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Reposted by Karen Slattery

Lydia Lynch @lydialynch.bsky.social · Dec 19

Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @natureportfolio.bsky.social Huge effort by whole team and collaborators to work this out. www.nature.com/articles/s41...

Article Metrics - Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis | Nature

www.nature.com

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Reposted by Karen Slattery

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Karen Slattery

Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · Nov 24

Working on immunometabolism? Or looking for people who do? Then here’s the starter pack for you! 😊 #Immunosky

go.bsky.app/MvxkA4Q

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