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Reposted by Michael Fischbach

Gabriel Victora @victora.bsky.social · Mar 19

Cool germinal center acrobatics from Juhee Pae et al, check it out!

www.nature.com/articles/s41...

www.nature.com

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Reposted by Michael Fischbach

Tami Lieberman @contaminatedsci.bsky.social · Dec 26

This pair of papers demonstrating strong and systemic immune responses to skin commensals applied topically to unbroken skin, including induction of B cells for vaccination.
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Skin autonomous antibody production regulates host-microbiota interactions - Nature

Nature - Skin autonomous antibody production regulates host-microbiota interactions

www.nature.com

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Reposted by Michael Fischbach

Dmitri Petrov @petrovadmitri.bsky.social · Dec 26

These are my favorites too! 🤯

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Reposted by Michael Fischbach

Christopher Barnes @cobarnes27.bsky.social · Dec 24

What an amazing story that was such a blast to collaborate on with @mfgrp.bsky.social lab!!! Phenomenal work led by @djenetbousbaine.bsky.social and all co-authors!! Unroll this thread and be amazed 🤯👇🏾

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

ImmunoSketch @immunosketch.bsky.social · Dec 21

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose.

@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com

t.co/xXXCJx5VYm
#ImmunoSky 🧪

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Reposted by Michael Fischbach

Itai Yanai @itaiyanai.bsky.social · Dec 20

A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. @mfgrp.bsky.social
open.spotify.com/episode/6KMh...

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Reposted by Michael Fischbach

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · Dec 16

Insanely creative and original immunology and bioengineering work from the Fischbach Lab at Stanford with high translational potential

Full article in NATURE: www.nature.com/articles/s41...

Follow the scientists:

@mfgrp.bsky.social
@djenetbousbaine.bsky.social
@katebauman.bsky.social

Stanford Scientists Transform Ubiquitous Skin Bacterium into a Topical Vaccine Against Tetanus

Even better, it’s cheap, entirely pain-free, no need to stand in a line, and not followed by fever, swelling, redness, or a sore arm.

www.goodnewsnetwork.org

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Reposted by Michael Fischbach

Taia Wang Laboratory @wanglaboratory.bsky.social · Dec 13

Beautiful work with exciting implications for topical vaccination by @mfgrp.bsky.social ✨

Give this a read 👇

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Stanford Department of Bioengineering @bioe-stanford.bsky.social · Dec 13

Vaccines, but make it skincare!🧴🧬 Congratulations to Stanford BioE Professor Michael Fischbach @mfgrp.bsky.social & @djenetbousbaine.bsky.social for engineering a skin bacterium that could lead to needle-free vaccines.

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Djenet Bousbaine @djenetbousbaine.bsky.social · Dec 12

Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Marshall Burke @marshallburke.bsky.social · Dec 12

Your hand lotion is now also a vaccine. Hot damn

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Christina (Chris) Tobin Kahrstrom @microchris.bsky.social · Dec 12

Two fascinating papers just out in Nature @natureportfolio.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Skin autonomous antibody production regulates host-microbiota interactions - Nature

Nature - Skin autonomous antibody production regulates host-microbiota interactions

www.nature.com

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Reposted by Michael Fischbach

Christina (Chris) Tobin Kahrstrom @microchris.bsky.social · Dec 12

Illuminating thread by author ‪@mfgrp.bsky.social

bsky.app/profile/mfgr...

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Andreas Peschel @andreaspeschel.bsky.social · Dec 12

Brilliant work congrats to the authors!

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Tim Stearns @stearnslab.bsky.social · Dec 11

Awesome thread from @mfgrp.bsky.social about what might be the most amazing result you'll hear about in 2024: antigens stuck on the surface of the skin bacterium S. epidermidis generate a strong immune response in mouse.

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Scott_Boyd_Lab_Stanford @scottboydlab.bsky.social · Dec 12

A remarkable story from @mfgrp.bsky.social and colleagues: immunization via skin S. epidermidis generates systemic and mucosal antibody responses.

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Dec 11

And in a Nature publication double-header, @mfgrp.bsky.social @stanford-chemh.bsky.social collaborates with Yasmine Belkaid and workers in this study reporting on local immune response including antibody generation in response to skin commensals:

www.nature.com/articles/s41...

Skin autonomous antibody production regulates host-microbiota interactions - Nature

Nature - Skin autonomous antibody production regulates host-microbiota interactions

www.nature.com

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Reposted by Michael Fischbach

Zamin Iqbal @zaminiqbal.bsky.social · Dec 11

This is the most amazing thread since they did a similar thing to cure a cancer

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Leyla Asadi, MD PhD @leylaaa.bsky.social · Dec 11

Wonder.
Awe.
Excitement.
Very cool thread on a very cool finding.

#IDSky

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Shai Bel (The Mucus Man) @mucusman.bsky.social · Dec 11

Holy shit this is amazing!!! 🤯

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Conor McClune @cmcclune.bsky.social · Dec 11

discovery that a skin microbe can, without inflammation, induce a systemic B-cell response... and then engineering that microbe into a potent vaccine platform that can be applied as a topical cream. amazing work from @djenetbousbaine.bsky.social and @mfgrp.bsky.social! www.nature.com/articles/s41...

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Reposted by Michael Fischbach

Sorek Lab @soreklab.bsky.social · Dec 11

An amazing discovery, and a very informative and engaging thread. Could develop into a transformative new mode for efficient vaccination

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Carolyn King @immunologyking.bsky.social · Dec 11

one to savor over the holidays. also so cool to see how the directions of the work between @mfgrp.bsky.social and Belkaid labs diverged.

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Leif Erik Sander 🇪🇺🇺🇦 @sanderlab.bsky.social · Dec 11

Brilliant 🧵on a fascinating study demonstrating potent systemic and mucosal antibody responses to the common skin commensal Staph. epidermidis. Engineered S. epi expressing or displaying unrelated antigens elicited protective immunity,suggesting it could serve as topical vaccines. 💉

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Michael Fischbach

Damian Maseda @dmaseda.bsky.social · Dec 11

Co-opting a skin commensal to design new vaccines! An amazingly creative and thoughtful new approach that integrates our knowledge of immune system responses. #ImmunoSky

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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