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Reposted by Djenet Bousbaine

Sarafan ChEM-H @stanford-chemh.bsky.social · Aug 5

'The vaccine we all wear'
In @science.org , Postdoc @djenetbousbaine.bsky.social writes about her work in Institute Scholar @mfgrp.bsky.social lab exploring the possibility of non-invasive topical vaccines that could be applied directly to the skin: www.science.org/doi/10.1126/...

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Djenet Bousbaine @djenetbousbaine.bsky.social · Jul 11

Congrats @cmcclune.bsky.social and the rest of the team!

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Jul 11

Check out this amazing new work from @sattelylab.bsky.social along with collaborator and @stanford-chemh.bsky.social Institute Scholar @pollyfordyce.bsky.social !

www.nature.com/articles/s41...

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature

An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

www.nature.com

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Djenet Bousbaine @djenetbousbaine.bsky.social · Jul 5

It’s truly an honor to receive this year’s
@science.org Noster Microbiome prize.

Here’s my essay on how we can engineer skin microbes to build topical vaccines:

Science Magazine @science.org · Jul 4

🎉 Congratulations to Djenet Bousbaine, winner of the 2025 NOSTER & Science Microbiome Prize for her work to illuminate how the immune system responds to the beneficial skin microbiome.

Learn more: scim.ag/4lVwpFx

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Reposted by Djenet Bousbaine

Stella Hurtley @smhsci.bsky.social · Jul 4

Check out the Noster prize winning essays @science.org The vaccine we all wear: Skin microbiota can be engineered into topical vaccines | Science www.science.org/doi/10.1126/...

The vaccine we all wear: Skin microbiota can be engineered into topical vaccines

Skin microbiota can be engineered into topical vaccines

www.science.org

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Reposted by Djenet Bousbaine

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Jul 4

Check out this prize-winning essay by postdoc @djenetbousbaine.bsky.social on her work with @mfgrp.bsky.social @stanford-chemh.bsky.social 👏

Stella Hurtley @smhsci.bsky.social · Jul 4

Check out the Noster prize winning essays @science.org The vaccine we all wear: Skin microbiota can be engineered into topical vaccines | Science www.science.org/doi/10.1126/...

The vaccine we all wear: Skin microbiota can be engineered into topical vaccines

Skin microbiota can be engineered into topical vaccines

www.science.org

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Djenet Bousbaine @djenetbousbaine.bsky.social · Jun 12

Check this beautiful work out of the Sattely lab by @cmcclune.bsky.social

Conor McClune @cmcclune.bsky.social · Jun 11

Today in Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III & deBz-deoxy-Taxol #SingleCell #secmet 🧬🧪🌾

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature

An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

www.nature.com

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Djenet Bousbaine @djenetbousbaine.bsky.social · Mar 6

Congrats @cobarnes27.bsky.social and @adonisrubio.bsky.social!

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Djenet Bousbaine @djenetbousbaine.bsky.social · Jan 26

Would love to be added. Many thanks!

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Djenet Bousbaine @djenetbousbaine.bsky.social · Dec 24

So thankful being able to work with you!

Christopher Barnes @cobarnes27.bsky.social · Dec 24

What an amazing story that was such a blast to collaborate on with @mfgrp.bsky.social lab!!! Phenomenal work led by @djenetbousbaine.bsky.social and all co-authors!! Unroll this thread and be amazed 🤯👇🏾

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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Reposted by Djenet Bousbaine

ImmunoSketch @immunosketch.bsky.social · Dec 21

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose.

@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com

t.co/xXXCJx5VYm
#ImmunoSky 🧪

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Reposted by Djenet Bousbaine

Sarah Ross @sarahhross.bsky.social · Dec 19

#Immunology by First release now @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection

https://buff.ly/3DjNQ1e

By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

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Reposted by Djenet Bousbaine

Alex Lercher @alercher.bsky.social · Dec 15

A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential!

Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs

tinyurl.com/5yahn47t
tinyurl.com/4n4btxap

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Reposted by Djenet Bousbaine

Christina (Chris) Tobin Kahrstrom @microchris.bsky.social · Dec 12

Two fascinating papers just out in Nature @natureportfolio.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Skin autonomous antibody production regulates host-microbiota interactions - Nature

Nature - Skin autonomous antibody production regulates host-microbiota interactions

www.nature.com

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Djenet Bousbaine @djenetbousbaine.bsky.social · Dec 12

Please also checkout the co-submitted manuscript from the very talented Inta Gribonika in Yasmine Belkaid's lab who dived deeper into the immunological processes involved in this response.

www.nature.com/articles/s41...

Skin autonomous antibody production regulates host-microbiota interactions - Nature

Nature - Skin autonomous antibody production regulates host-microbiota interactions

www.nature.com

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Djenet Bousbaine @djenetbousbaine.bsky.social · Dec 12

Maggie Swenson, Tam Nguyen and the rest of the team. Our incredibly supportive collaborators @cobarnes27.bsky.social Yasmine Belkaid, Julie Segre, Heidi Kong, Koen Rompay and my funding sources @snsf-ch.bsky.social and @niaidnews.bsky.social

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Djenet Bousbaine @djenetbousbaine.bsky.social · Dec 12

Special thanks to all the co-authors in particular Erin Chen who took me under her wing at the beginning of my postdoc,
@katebauman.bsky.social and Pranav lalgudi who helped me push this through the finish line and our wonderful support staff in the lab Victor yu, Eunice Tsang, ...

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Djenet Bousbaine @djenetbousbaine.bsky.social · Dec 12

Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

Michael Fischbach @mfgrp.bsky.social · Dec 11

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

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