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Kasper van Gelderen

@kaspervangelderen.bsky.social

1.2K followers 780 following 23 posts

Plant Cell Biologist, Group leader at Centre for Organismal Studies, Heidelberg University https://www.cos.uni-heidelberg.de/en/research-groups/light-signaling-and-cell-biology

www.cos.uni-heidelberg.de

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Kasper van Gelderen @kaspervangelderen.bsky.social · 8d

My latest paper, a postdoc project of mine from the @ronaldpierik.bsky.social lab is finally out in the Plant Cell all its formatted glory! doi.org/10.1093/plce...
Many thanks also to my co-authors and especially Kyra van der Velde who did a lot of work.

Gibberellin transport affects lateral root growth through HY5 in response to far-red light

Gibberellin translocation from shoot to root conveys a plant-plant competition signal that leads to a reduction in lateral root growth.

doi.org

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Reposted by Kasper van Gelderen

Vinay Shukla @vinayshukla.bsky.social · 3d

ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism
www.cell.com/cell/fulltex...
#plantscience

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Reposted by Kasper van Gelderen

The Company of Biologists @biologists.bsky.social · 5d

You can read Mark's 2024 @dev-journal.bsky.social Review article here: doi.org/10.1242/dev....

40 years since the Heidelberg genetic screen that revolutionized developmental and cell biology

ABSTRACT. Our current understanding of the molecular basis of embryonic development and the shared machinery underlying this remarkable process has its roots in three papers published 40 years ago, wh...

doi.org

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Reposted by Kasper van Gelderen

GeminiTeamLab @geminiteamlab.bsky.social · 5d

How do geminiviruses maximize their limited coding capacity? Our recent preprint uncovers splicing of viral transcripts as one more strategy used by this viral family. We show that RNA splicing is prevalent in the geminivirus TYLCV — and required for infectivity! www.biorxiv.org/content/10.1...

Pervasive splicing in a plant DNA virus

Viruses maximize their limited coding space through strategies that increase transcript and protein diversity. In mammalian viruses, splicing is a well-established mechanism for proteome expansion, ye...

www.biorxiv.org

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Vinay Shukla @vinayshukla.bsky.social · 5d

HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato
www.nature.com/articles/s41...
#plantscience

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Kasper van Gelderen @kaspervangelderen.bsky.social · 8d

Haha, yeah, took a while 😂
I started this project ten years ago(!)

Kasper van Gelderen @kaspervangelderen.bsky.social · 8d

Since both GA and HY5 can be transported from shoot to root, this begs the question of how this shoot to root transport is regulated and how GA and HY5 integrate their signalling. Exciting work for the future 😊

Model of GA4 shoot to root transport in shade avoidance, and how it integrates with HY5 signaling. (Copyright the Plant Cell)

Kasper van Gelderen @kaspervangelderen.bsky.social · 8d

It turns out that a large part of the GA response is coming via HY5 (My favourite transcription factor). GA can increase HY5 levels in the lateral root primordium, leading to a reduction in lateral root growth. hy5 mutants, repsond less to very high GA4 addition!

Iamges of HY5-GFP at the lateral root primordium, either with or wtihout |Giberellin given to the shoot. (Copyright the Plant Cell)

The response of wild type (Col-0) to 10 uM GA4 is much stronger than that of the hy5 hyh knockout mutant. (Copyright the Plant Cell)

Kasper van Gelderen @kaspervangelderen.bsky.social · 8d

We can modify and remove that far-red light response by applying GA to the shoot, and when we applied far-red light to mimic shading by plant competition, we detected increased amounts of GA in the root via a FRET sensor, GPS1 (from the lab of @xanderjones.bsky.social ).

The FRET sensor GPS1 can detect GA though the monitoring of it's fluorescence ratio, as quantifiied in these figures. Below, ratiometric images are shown of root tissues. (Copyright the Plant Cell)

GA4 addition to the shoot alone can reduce root growth, and simulate the WL+FR effect on root growth. (Copyright, the Plant Cell)

Kasper van Gelderen @kaspervangelderen.bsky.social · 8d

Plants can perceive adverse light conditions, such as shading through far-red light, and change their growth.
Gibberellins (GA’s) are known to control cell growth in the shoot, but we show now that they can also act as a signaling hormone from shoot to root, and change root development!

Effect of GA4 addition to growing Arabidopsis seedlings in white light (WL) and WL+far-red light (WL+FR).
Copyright: the Plant Cell

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Kasper van Gelderen @kaspervangelderen.bsky.social · 8d

Gibberellin transport affects lateral root growth through HY5 in response to far-red light

Gibberellin translocation from shoot to root conveys a plant-plant competition signal that leads to a reduction in lateral root growth.

doi.org

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Reposted by Kasper van Gelderen

eLife @elife.bsky.social · 10d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

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Reposted by Kasper van Gelderen

GeminiTeamLab @geminiteamlab.bsky.social · 29d

📢 A Junior Professorship (W1, tenure track) is open at the Center for Plant Molecular Biology at Uni Tübingen (@zmbp-tuebingen.bsky.social) — to work on plant protein biochemistry (composition, structure, dynamics, or regulation of protein complexes). 🌱 Great opportunity — Apply by Oct 17th!

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Ronald Pierik @ronaldpierik.bsky.social · Aug 29

Our latest paper with great work by @kaspervangelderen.bsky.social, Kyra vd Velde and others from our labs on how photoreceptor signals in the shoot can regulate root development. Lovely microscopy and hormone micro-manipulations by Kyra and Kasper!

Ronald Pierik @ronaldpierik.bsky.social · Aug 28

New paper: Gibberellins are long-distance regulators of shoot-to-root signalling of the light environment

Our latest paper ( published online in Plant Cell, shows that Gibberellins are involved in long-distance signalling of phytochrome-sensed light signals all the way in to the roots that are not…

New paper: Gibberellins are long-distance regulators of shoot-to-root signalling of the light environment

Our latest paper ( published online in Plant Cell, shows that Gibberellins are involved in long-distance signalling of phytochrome-sensed light signals all the way in to the roots that are not light-exposed but still respond to light quality changes. We think that not only the precursor GA12, but also bioactive GA4 is shoot-to-root mobile. The work was led by former postdoc…

plantphotobiology.com

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Reposted by Kasper van Gelderen

The Plant Cell @theplantcell.bsky.social · Aug 28

Gibberellin transport affects lateral root growth through HY5 in response to far-red light (Kasper van Gelderen , Kyra van der Velde , Chia-kai Kang , Jessy Hollander , Alicia Koppenol , Orfeas Petropoulos , Putri Prasetyaningrum , Tuğba Akyüz , Ronald Pierik) doi.org/10.1093/plce... #PlantScience

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Shiori Iida @shiori-iida.bsky.social · Aug 29

One more movie!
Using the RL algorithm (from pnas.org/doi/10.1073/...),
@masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility.
Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)

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Universität Heidelberg @uniheidelberg.bsky.social · Aug 11

Four New Cross-Border Doctoral Networks at Universität Heidelberg – European Commission funds establishment of MSCA Doctoral Networks focused on highly innovative research topics www.uni-heidelberg.de/en/newsroom/...

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Kasper van Gelderen @kaspervangelderen.bsky.social · Jun 17

Very thought-provoking talk by @wigge.bsky.social #ICAR2025
IDRs, intrinsically disordered regions, could stack as parallel beta sheets and respond to temperature that way!

Reposted by Kasper van Gelderen

Suayb Üstün @suaybuestuen.bsky.social · Jun 16

It‘s about to start - such an amazing venue for #ICAR2025

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Marc Somssich @somssich.bsky.social · Jan 15

📜 Super-resolution expansion microscopy in plant roots

🧑‍🔬 Michelle Gallei, Sven Truckenbrodt, Johann G. Danzl, et al.

📔 @theplantcell.bsky.social

🔗 academic.oup.com/plcell/advan...

#️⃣ #PlantScience #PlantMicroscopy #PlantImaging #PlantSuperRes

Super-resolution expansion microscopy in plant roots

The development of expansion microscopy in the Arabidopsis root enabled the imaging of molecular targets in tissues at diffraction-unlimited resolution.

academic.oup.com

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Suayb Üstün @suaybuestuen.bsky.social · Jan 14

Happy to share our latest @biorxiv-plants.bsky.social led by @manuelgonzalezfuen.bsky.social “Effector-triggered processing body formation attenuates host translation via ER stress responses and autophagy upon bacterial infection” #proteostasis #plantimmunity 🧵(1/16)
www.biorxiv.org/content/10.1...

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Marc Somssich @somssich.bsky.social · Jan 13

Cool graphic from KWS on the #GenomeEditing timeline.

Impressive how few years passed between the first use of CRISPR/Cas9 in a crop plant (2013) to the first release of an edited crop ( #GABATomato ) (2021). Trad. #PlantBreeding can take decades! 😮

www.kws.com/corp/de/inno...
#PlantScience

Timeline of genome editing innovations from KWS. Taken from https://www.kws.com/corp/de/innovation/pflanzenzuechtung/zuechtungsmethoden/genome-editing/
It shows 18 steps from 1985 (Entdeckung von Zinkfingernukleasen) to 2021 (Markteinführung der ersten genomeditierten Tomate). 2002 is the first use of CRISPR/Cas9, 2005 the first use of genome editing in plants, 2013 the first use of CRISPR/Cas9 in a crop plant, and then, 2021 the release of the CRISPR-edited GABA-tomato to the Japanese consumer market.

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Maizel lab @maizel-lab.org · Jan 8

Delighted to announce the 18th #FASEB Mechanisms of Plants Development will take place Aug 24-28th. ‼️ Register before June 29th → tinyurl.com/24fsjq6a
🌱 🎁 Vote for the conference image by Jan 31st
→ tinyurl.com/2872w6vm
The poster & speakers lineup will be announced in early Feb.
Spread the word!

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Charles Melnyk @charlesmelnyk.bsky.social · Nov 12

A Senior Lecturer/Associate Professor position is available in the Plant Biology Department at SLU, related to how plants grow, develop & interact with their environment. Come join us in a welcoming and dynamic department in Uppsala, Sweden! More info below:
www.slu.se/en/about-slu...

Jobs and vacancies at SLU. | slu.se

Jobs and vacancies at SLU. Read more about each job by clicking the job title. Please, follow the instructions closely when applying.

www.slu.se

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Daniel Martínez PhD @dmartinezphd.bsky.social · Dec 13

My postdoc was partially funded by a ball of platinum that my mentor found during a lab clean out. Somehow the university treated as unclaimed treasure and he used the proceeds of the sale to cover some of my salary. Postdoc resulted in a little paper that was my most cited and led to 3 books!

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Dr Emma Hodcroft @firefoxx66.bsky.social · Dec 19

WHY do we have so many deadlines in early January?

Why do Orgs in countries that overwhelmingly celebrate Christmas do this? These deadlines aren't natural phenomena - we are in control of this!!

We don't we just... not? And let everyone have a genuine break? 🤔🙃

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