Kaustubh Kulkarni
@krkulkarni.bsky.social
Research track psychiatry resident @ Yale
Computational psychiatry, addiction, neuroimaging, neuromodulation
Computational psychiatry, addiction, neuroimaging, neuromodulation
Reposted by Kaustubh Kulkarni
Thoughtful review with some good recent historical perspective on the ongoing paradigm shift that is radically changing the way we think about what brain areas do.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience
Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...
www.nature.com
December 4, 2025 at 5:56 PM
Thoughtful review with some good recent historical perspective on the ongoing paradigm shift that is radically changing the way we think about what brain areas do.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kaustubh Kulkarni
Exciting new work from @lindenmp.bsky.social and friends!
Inferring intrinsic neural timescales using optimal control theory
www.nature.com/articles/s41...
Inferring intrinsic neural timescales using optimal control theory
www.nature.com/articles/s41...
Inferring intrinsic neural timescales using optimal control theory - Nature Communications
Here, the authors develop novel dynamical methods to model brain regions’ intrinsic neural timescales (INTs) from data, and find that they couple whole-brain structural connectivity to dynamic switchi...
www.nature.com
December 2, 2025 at 8:26 PM
Exciting new work from @lindenmp.bsky.social and friends!
Inferring intrinsic neural timescales using optimal control theory
www.nature.com/articles/s41...
Inferring intrinsic neural timescales using optimal control theory
www.nature.com/articles/s41...
Reposted by Kaustubh Kulkarni
New study out today in Nature Comms: www.nature.com/articles/s41..., in which we set out to test whether ultrasound could influence the reward-related learning computations of the nucleus accumbens, building on decades of work on dopaminergic prediction error and reinforcement learning. And it did.
Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity - Nature Communications
This study shows that non-invasive ultrasound to the human nucleus accumbens can modulate deep brain activity and enhance reward-guided learning, offering a potential alternative to invasive neuromodu...
www.nature.com
November 28, 2025 at 12:26 PM
New study out today in Nature Comms: www.nature.com/articles/s41..., in which we set out to test whether ultrasound could influence the reward-related learning computations of the nucleus accumbens, building on decades of work on dopaminergic prediction error and reinforcement learning. And it did.
Reposted by Kaustubh Kulkarni
Another nail in the coffin for PCA?
- doesn’t linearize, distorting similarity metrics
- is biased by temporal jitter across epochs
- may miss important dimensions for transient amplification
If you think there is a state space, use a state space model!
- doesn’t linearize, distorting similarity metrics
- is biased by temporal jitter across epochs
- may miss important dimensions for transient amplification
If you think there is a state space, use a state space model!
“Our findings challenge the conventional focus on low-dimensional coding subspaces as a sufficient framework for understanding neural computations, demonstrating that dimensions previously considered task-irrelevant and accounting for little variance can have a critical role in driving behavior.”
Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification
Most behaviors involve neural dynamics in high-dimensional activity spaces. A common approach is to extract dimensions that capture task-related variability, such as those separating stimuli or choice...
www.biorxiv.org
November 23, 2025 at 3:16 PM
Another nail in the coffin for PCA?
- doesn’t linearize, distorting similarity metrics
- is biased by temporal jitter across epochs
- may miss important dimensions for transient amplification
If you think there is a state space, use a state space model!
- doesn’t linearize, distorting similarity metrics
- is biased by temporal jitter across epochs
- may miss important dimensions for transient amplification
If you think there is a state space, use a state space model!
Reposted by Kaustubh Kulkarni
📣🔥Thrilled to announce that 2026 Computational Psychiatry Conference will take place in New Haven, CT, btw July 14-16 -
www.cpconf.org
@robbrutledge.bsky.social @drrickadams.bsky.social @tobiasuhauser.bsky.social @docqhuys.bsky.social @clairegillan.bsky.social Sonia Bishop
More info to come soon!
www.cpconf.org
@robbrutledge.bsky.social @drrickadams.bsky.social @tobiasuhauser.bsky.social @docqhuys.bsky.social @clairegillan.bsky.social Sonia Bishop
More info to come soon!
November 21, 2025 at 7:27 PM
📣🔥Thrilled to announce that 2026 Computational Psychiatry Conference will take place in New Haven, CT, btw July 14-16 -
www.cpconf.org
@robbrutledge.bsky.social @drrickadams.bsky.social @tobiasuhauser.bsky.social @docqhuys.bsky.social @clairegillan.bsky.social Sonia Bishop
More info to come soon!
www.cpconf.org
@robbrutledge.bsky.social @drrickadams.bsky.social @tobiasuhauser.bsky.social @docqhuys.bsky.social @clairegillan.bsky.social Sonia Bishop
More info to come soon!
Reposted by Kaustubh Kulkarni
Excited to share this review in @biologicalpsych.bsky.social on using transfer learning to leverage large MRI datasets & enhance precision psychiatry!!
www.biologicalpsychiatryjournal.com/article/S000...
Fun collab with rockstars @diawang.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social
www.biologicalpsychiatryjournal.com/article/S000...
Fun collab with rockstars @diawang.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social
From big to small: Emerging methods for enhancing precision psychiatry through transfer learning
Identifying reliable links between individual differences in neurobiological features
and differences in symptom profiles or treatment outcomes is a primary goal of precision
psychiatry. Within this c...
www.biologicalpsychiatryjournal.com
October 30, 2025 at 3:21 PM
Excited to share this review in @biologicalpsych.bsky.social on using transfer learning to leverage large MRI datasets & enhance precision psychiatry!!
www.biologicalpsychiatryjournal.com/article/S000...
Fun collab with rockstars @diawang.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social
www.biologicalpsychiatryjournal.com/article/S000...
Fun collab with rockstars @diawang.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social
Reposted by Kaustubh Kulkarni
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
September 19, 2025 at 1:05 PM
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
Reposted by Kaustubh Kulkarni
The TiCS issue featuring our paper on "A timeline of cognitive costs in decision-making" is now available online 😄
Honored to have been a part of this awesome interdisciplinary mega-collab led by Christin Schulze (UNSW Sydney)
www.cell.com/trends/cogni...
Honored to have been a part of this awesome interdisciplinary mega-collab led by Christin Schulze (UNSW Sydney)
www.cell.com/trends/cogni...
A timeline of cognitive costs in decision-making
Recent research from economics, psychology, cognitive science, computer science, and
marketing is increasingly interested in the idea that people face cognitive costs
when making decisions. Reviewing ...
www.cell.com
September 3, 2025 at 12:15 AM
The TiCS issue featuring our paper on "A timeline of cognitive costs in decision-making" is now available online 😄
Honored to have been a part of this awesome interdisciplinary mega-collab led by Christin Schulze (UNSW Sydney)
www.cell.com/trends/cogni...
Honored to have been a part of this awesome interdisciplinary mega-collab led by Christin Schulze (UNSW Sydney)
www.cell.com/trends/cogni...
Reposted by Kaustubh Kulkarni
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
Discovering cognitive strategies with tiny recurrent neural networks - Nature
Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...
doi.org
July 2, 2025 at 7:03 PM
Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...
Reposted by Kaustubh Kulkarni
Better Code, Better Science - Introducing a new open-source book project on scientific coding using AI tools russpoldrack.substack.com/p/better-cod...
Better Code, Better Science
Introducing a new open-source book project on scientific coding using AI tools
russpoldrack.substack.com
May 14, 2025 at 4:28 PM
Better Code, Better Science - Introducing a new open-source book project on scientific coding using AI tools russpoldrack.substack.com/p/better-cod...
Reposted by Kaustubh Kulkarni
Just Now: a federal judge ruled that our case (AAUP v. Rubio) seeking to block the Trump admin from carrying out large-scale arrests, detentions, & deportations of noncitizen students & faculty members who participate in pro-Palestinian protests can go forward.
@knightcolumbia.org
@knightcolumbia.org
Federal Court Says First Amendment Bars Government From Deporting Students and Faculty on Basis of Political Viewpoint, Says Challenge to Trump Policy Can Go Forward
knightcolumbia.org
April 29, 2025 at 7:36 PM
Just Now: a federal judge ruled that our case (AAUP v. Rubio) seeking to block the Trump admin from carrying out large-scale arrests, detentions, & deportations of noncitizen students & faculty members who participate in pro-Palestinian protests can go forward.
@knightcolumbia.org
@knightcolumbia.org
Reposted by Kaustubh Kulkarni
𝗛𝗼𝘄 𝘀𝗵𝗼𝘂𝗹𝗱 𝘄𝗲 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻𝗱 𝗱𝗲𝘁𝗲𝗿𝗺𝗶𝗻𝗲 𝗮 𝗯𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻'𝘀 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝗰𝗲?
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...
Brain dynamics and spatiotemporal trajectories during threat processing
elifesciences.org
April 27, 2025 at 5:17 PM
𝗛𝗼𝘄 𝘀𝗵𝗼𝘂𝗹𝗱 𝘄𝗲 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻𝗱 𝗱𝗲𝘁𝗲𝗿𝗺𝗶𝗻𝗲 𝗮 𝗯𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻'𝘀 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝗰𝗲?
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...
Reposted by Kaustubh Kulkarni
Proud to announce our primer on "Ten principles for reliable, efficient, and adaptable coding in psychology and cognitive neuroscience"
www.nature.com/articles/s44...
This primer is for beginners to get started, advanced programmers to improve, and PIs.
#psychology #psychsci #cogsci #neuroskyence
www.nature.com/articles/s44...
This primer is for beginners to get started, advanced programmers to improve, and PIs.
#psychology #psychsci #cogsci #neuroskyence
Ten principles for reliable, efficient, and adaptable coding in psychology and cognitive neuroscience - Communications Psychology
Programming is essential for modern research in neuroscience and psychology, but it can quickly become a source of frustration and error. This Primer introduces ten practical principles guiding resear...
www.nature.com
April 15, 2025 at 12:41 PM
Proud to announce our primer on "Ten principles for reliable, efficient, and adaptable coding in psychology and cognitive neuroscience"
www.nature.com/articles/s44...
This primer is for beginners to get started, advanced programmers to improve, and PIs.
#psychology #psychsci #cogsci #neuroskyence
www.nature.com/articles/s44...
This primer is for beginners to get started, advanced programmers to improve, and PIs.
#psychology #psychsci #cogsci #neuroskyence
Reposted by Kaustubh Kulkarni
In his new book, published today, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments.
#neuroskyence
www.thetransmitter.org/systems-neur...
#neuroskyence
www.thetransmitter.org/systems-neur...
‘Natural Neuroscience,’ an excerpt
In his new book, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments.
www.thetransmitter.org
April 15, 2025 at 1:11 PM
In his new book, published today, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments.
#neuroskyence
www.thetransmitter.org/systems-neur...
#neuroskyence
www.thetransmitter.org/systems-neur...
Reposted by Kaustubh Kulkarni
🚨 New study alert! 🚨
Ever wondered if rats and humans learn in the same way? 🐭🧑🔬
We tested this — and the answer is yes, at least when it comes to how we value rewards in context.
(with @shaunaparkes.bsky.social Lachlan Ferguson, Magdalena Soukupova)
🧵Thread 👇
1/
www.biorxiv.org/content/10.1...
Ever wondered if rats and humans learn in the same way? 🐭🧑🔬
We tested this — and the answer is yes, at least when it comes to how we value rewards in context.
(with @shaunaparkes.bsky.social Lachlan Ferguson, Magdalena Soukupova)
🧵Thread 👇
1/
www.biorxiv.org/content/10.1...
Reference Point-Dependent Reinforcement Learning in Humans and Rats
Previous studies indicate that rewards and punishments in reinforcement learning are encoded in a relative manner. Reference point-dependence, a valuation bias shared by eminent adaptation level and p...
www.biorxiv.org
April 14, 2025 at 8:49 AM
🚨 New study alert! 🚨
Ever wondered if rats and humans learn in the same way? 🐭🧑🔬
We tested this — and the answer is yes, at least when it comes to how we value rewards in context.
(with @shaunaparkes.bsky.social Lachlan Ferguson, Magdalena Soukupova)
🧵Thread 👇
1/
www.biorxiv.org/content/10.1...
Ever wondered if rats and humans learn in the same way? 🐭🧑🔬
We tested this — and the answer is yes, at least when it comes to how we value rewards in context.
(with @shaunaparkes.bsky.social Lachlan Ferguson, Magdalena Soukupova)
🧵Thread 👇
1/
www.biorxiv.org/content/10.1...
Reposted by Kaustubh Kulkarni
Unidentified men grabbing someone off the street and putting her in a car because she wrote an op-Ed. This as flatly authoritarian as anything we’ve seen in this country in a very long time.
Video of the international student at Tufts being arrested by "federal authorities" in Massachusetts has been released and it's terrifying.
They're not even uniformed officers. Just secret police thugs in hoodies and masks.
From WCVB: youtu.be/PuFIs7OkzYY
They're not even uniformed officers. Just secret police thugs in hoodies and masks.
From WCVB: youtu.be/PuFIs7OkzYY
March 26, 2025 at 5:41 PM
Unidentified men grabbing someone off the street and putting her in a car because she wrote an op-Ed. This as flatly authoritarian as anything we’ve seen in this country in a very long time.
Reposted by Kaustubh Kulkarni
🚨New lab preprint alert!🚨
Grab a drink, sit down, and let me walk you through the moment-by-moment process of how information loops through basal ganglia circuits during a decision.
(Link at the end of the thread)
1/9
Grab a drink, sit down, and let me walk you through the moment-by-moment process of how information loops through basal ganglia circuits during a decision.
(Link at the end of the thread)
1/9
March 24, 2025 at 7:29 PM
🚨New lab preprint alert!🚨
Grab a drink, sit down, and let me walk you through the moment-by-moment process of how information loops through basal ganglia circuits during a decision.
(Link at the end of the thread)
1/9
Grab a drink, sit down, and let me walk you through the moment-by-moment process of how information loops through basal ganglia circuits during a decision.
(Link at the end of the thread)
1/9
Reposted by Kaustubh Kulkarni
Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder?
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder
In the field of deep brain stimulation (DBS), two major themes are currently making
significant progress. First, the framework of connectomic DBS, in which circuits that
are associated with improvemen...
www.biologicalpsychiatryjournal.com
March 21, 2025 at 4:13 PM
Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder?
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Reposted by Kaustubh Kulkarni
Explore the newly launched Early-Career Neuroscientists Resource Center, designed to help you navigate the field with news, expert insights and practical tools. The page also highlights job openings, seminars, and more:
#neuroskyence
www.thetransmitter.org/early-career...
#neuroskyence
www.thetransmitter.org/early-career...
Early-Career Neuroscientists Resource Center
News, perspectives and resources to help navigate the early stages of your neuroscience career
www.thetransmitter.org
March 20, 2025 at 9:12 PM
Explore the newly launched Early-Career Neuroscientists Resource Center, designed to help you navigate the field with news, expert insights and practical tools. The page also highlights job openings, seminars, and more:
#neuroskyence
www.thetransmitter.org/early-career...
#neuroskyence
www.thetransmitter.org/early-career...
Reposted by Kaustubh Kulkarni
If a doctor is going to stimulate your brain, should they receive special training first? Congrats @shansiddiqi.bsky.social @braincircuits.bsky.social on leading this effort to make brain stimulation a certified clinical subspecialty: www.sciencedirect.com/science/arti...
Towards accredited clinical training in brain stimulation: Proceedings from the brain stimulation subspecialty summits
The rapid development and clinical use of brain stimulation has renewed debates about whether to define and accredit a pathway for clinical subspecial…
www.sciencedirect.com
March 7, 2025 at 12:45 PM
If a doctor is going to stimulate your brain, should they receive special training first? Congrats @shansiddiqi.bsky.social @braincircuits.bsky.social on leading this effort to make brain stimulation a certified clinical subspecialty: www.sciencedirect.com/science/arti...
Reposted by Kaustubh Kulkarni
Make use of our public database of Postdoc fellowships (private foundations, federal agencies). It's downloadable and free.
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
March 5, 2025 at 5:12 PM
Make use of our public database of Postdoc fellowships (private foundations, federal agencies). It's downloadable and free.
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria
Download here: research.jhu.edu/rdt/funding-...
Reposted by Kaustubh Kulkarni
“Today’s meeting confirmed that the US is now aligned with Russia and against Ukraine, Europe, and most of the planet. I felt physically sick watching the president yell at a brave ally…”
@radiofreetom.bsky.social
The US is marching to authoritarianism and THAT is why they’re attacking #NIH … 1/
@radiofreetom.bsky.social
The US is marching to authoritarianism and THAT is why they’re attacking #NIH … 1/
It Was an Ambush
Today marked one of the grimmest days in the history of American diplomacy.
www.theatlantic.com
March 1, 2025 at 5:26 AM
“Today’s meeting confirmed that the US is now aligned with Russia and against Ukraine, Europe, and most of the planet. I felt physically sick watching the president yell at a brave ally…”
@radiofreetom.bsky.social
The US is marching to authoritarianism and THAT is why they’re attacking #NIH … 1/
@radiofreetom.bsky.social
The US is marching to authoritarianism and THAT is why they’re attacking #NIH … 1/
Reposted by Kaustubh Kulkarni
New newsletter alert! We're relaunching Null and Noteworthy, a monthly roundup about null results and replications in neuroscience research. This month: A failed replication of a potential schizophrenia biomarker.
By Laura Dattaro
#neuroskyence
www.thetransmitter.org/null-and-not...
By Laura Dattaro
#neuroskyence
www.thetransmitter.org/null-and-not...
Null and Noteworthy, relaunched: Probing a schizophrenia biomarker
This edition of Null and Noteworthy—the first for The Transmitter—highlights new findings about the auditory steady-state response in people with schizophrenia that, all within one study…
www.thetransmitter.org
February 28, 2025 at 3:40 PM
New newsletter alert! We're relaunching Null and Noteworthy, a monthly roundup about null results and replications in neuroscience research. This month: A failed replication of a potential schizophrenia biomarker.
By Laura Dattaro
#neuroskyence
www.thetransmitter.org/null-and-not...
By Laura Dattaro
#neuroskyence
www.thetransmitter.org/null-and-not...
Reposted by Kaustubh Kulkarni
Freezing out the NIH's funding means freezing out American innovation.
Research into curing cancer, Alzheimer's, and Parkinson's all delayed.
And ultimately it won't just cost us advancements in life-saving research, it will cost us lives.
Research into curing cancer, Alzheimer's, and Parkinson's all delayed.
And ultimately it won't just cost us advancements in life-saving research, it will cost us lives.
NIH funding cuts could have ‘devastating impact’ on medical advancements, Chicago researchers say
The National Institutes of Health under President Donald Trump announced this month that it was cutting payments covering overhead costs for research institutions that receive its grants.
www.wbez.org
February 23, 2025 at 5:27 PM
Freezing out the NIH's funding means freezing out American innovation.
Research into curing cancer, Alzheimer's, and Parkinson's all delayed.
And ultimately it won't just cost us advancements in life-saving research, it will cost us lives.
Research into curing cancer, Alzheimer's, and Parkinson's all delayed.
And ultimately it won't just cost us advancements in life-saving research, it will cost us lives.
Reposted by Kaustubh Kulkarni
Call today to let your Congressman know what you think about Elon Musk’s DOGE and its slash-and-burn cuts to the federal workforce and vital government programs. Leave a message if necessary. YOUR CALLS REALLY DO MAKE A DIFFERENCE! ☎️
February 22, 2025 at 4:35 PM
Call today to let your Congressman know what you think about Elon Musk’s DOGE and its slash-and-burn cuts to the federal workforce and vital government programs. Leave a message if necessary. YOUR CALLS REALLY DO MAKE A DIFFERENCE! ☎️