By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...

Amid Trump research cuts, visa restrictions, and international conflicts, some winners sit out the celebration of whimsical science

A full-time tenure-track assistant professor position at the IRBV, Université de Montréal.

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Transfer RNA-derived small RNAs (tsRNAs, or tDRs) perform a range of cellular functions. Here, we showed that a hypoxia-induced tDR, derived from the 3′ end of tRNA-Asp-GTC (tRNA-Asp-GTC-3′tDR), activ...

In structure-function studies, Gamerdinger and Echeverria et al. uncover the cotranslational mechanism of N-myristoyltransferases (NMTs), essential enzymes that attach a lipid anchor to newborn proteins. They show that NMT activity is orchestrated by a key regulator at the ribosomal tunnel exit, the nascent polypeptide-associated complex (NAC).

Plant viruses are obligate intracellular pathogens that hijack host cellular machinery to support their replication and spread. Viral infection induces a variety of structural and physiological change...

Efficient delivery systems are urgently needed for genome editing in monocot plants. Here, this study develops a system of virus-induced genome editing in tillers (ViGET) to achieve heritable editing ...

Genetic variance is vital for breeding programs and mutant screening, yet traditional mutagenesis methods wrestle with genetic redundancy and a lack of specificity in gene targeting. Here the authors ...

The current “consensus” order in which amino acids were added to the genetic code is based on potentially biased criteria, such as the absence of s...